A5090452668- Coronary Interventions and Diagnostics
- Peripheral Artery Disease Management
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac and Coronary Surgery Techniques
- Cardiac Valve Diseases and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Vascular Procedures and Complications
- Aortic aneurysm repair treatments
- Muscle metabolism and nutrition
- Peroxisome Proliferator-Activated Receptors
- Cholesterol and Lipid Metabolism
- Health Systems, Economic Evaluations, Quality of Life
- Cancer, Lipids, and Metabolism
- Renal and Vascular Pathologies
- Dialysis and Renal Disease Management
- Advanced X-ray and CT Imaging
- Cardiac Structural Anomalies and Repair
- Aortic Thrombus and Embolism
- Diagnosis and Treatment of Venous Diseases
- Radiation Dose and Imaging
- Mycobacterium research and diagnosis
- Cardiovascular Function and Risk Factors
- Acute Kidney Injury Research
Saddleback Memorial Medical Center
2023
University of California, San Diego
2014-2018
Scripps Research Institute
2017
University of Szeged
2016
VA North Texas Health Care System
2016
The University of Texas Southwestern Medical Center
2016
VA San Diego Healthcare System
2015-2016
University of California San Diego Medical Center
2015-2016
Columbia University Irving Medical Center
2016
NewYork–Presbyterian Hospital
2016
Background— We sought to examine the efficacy and safety of chronic total occlusion percutaneous coronary intervention using retrograde approach. Methods Results— compared outcomes versus antegrade-only approach among 1301 procedures performed at 11 experienced US centers between 2012 2015. The mean age was 65.5±10 years, 84% patients were men with a high prevalence diabetes mellitus (45%) previous artery bypass graft surgery (34%). Overall technical procedural success rates 90% 89%,...
Significance The beneficial effects of LXR-pathway activation have long been appreciated, but clinical application synthetic LXR ligands has limited by coactivation SREBP1c and consequent hypertriglyceridemia. Natural such as desmosterol do not promote hypertriglyceridemia because coordinate down-regulation the SREBP pathway. Here we demonstrate that mimetics activate in macrophages both vitro vivo while suppressing target genes. Unexpectedly, almost no effect on activity hepatocytes...
The safety and feasibility of robotically‐assisted percutaneous coronary intervention (PCI) for simple lesions has been demonstrated. CorPath robotic system (Corpath 200, Corindus, Waltham, MA) consists a arm mounted on the cardiac catheterization table that drive housing single‐use sterile cassette, which is connected to guiding catheter. While sitting in nonsterile, radiation‐shielded cockpit, operator remotely controls delivery removal guidewires, angioplasty balloons, stents. database...
Balloon uncrossable lesions can be challenging to treat, requiring specialized techniques and equipment.We examined the prevalence, clinical angiographic characteristics, management procedural outcomes of balloon in a multicenter chronic total occlusion (CTO) percutaneous coronary intervention (PCI) registry.Between 2012 2016, 718 CTO PCIs (in which was successfully crossed with guidewire) were performed 701 patients at 11 US centers. Mean age 65.6 ± 10 years 84% men. represented 9% all...
Background Intravascular imaging can facilitate chronic total occlusion ( CTO ) percutaneous coronary intervention. Methods and Results We examined the frequency of use outcomes intravascular among 619 interventions performed between 2012 2015 at 7 US centers. Mean age was 65.4±10 years 85% patients were men. used in 38%: ultrasound 36%, optical coherence tomography 3%, both 1.45%. for stent sizing (26.3%), optimization (38.0%), crossing (35.7%, antegrade 27.9%, retrograde 7.8%). to more...
Objectives We sought to describe contemporary guidewire and microcatheter utilization for antegrade wire escalation (AWE) during chronic total occlusion (CTO) percutaneous coronary intervention (PCI). Background Equipment AWE has been variable evolving over time. Methods examined device 694 attempts in 679 patients performed at 15 experienced US centers between May 2012 April 2015. Results Mean age was 65.6 ± 9.7 years, 85% of the were men. Successful wiring occurred 436 (63%). Final...
Abstract Aim To examine the impact of diabetes mellitus on procedural outcomes patients who underwent percutaneous coronary intervention for chronic total occlusion. Methods We assessed occlusion among 1308 people such procedures at 11 US centres between 2012 and 2015. Results The participants’ mean ± sd age was 66 10 years, 84% participants were men 44.6% had diabetes. As compared with without diabetes, more likely to have undergone artery bypass graft surgery (38 vs 31%; P = 0.006),...
The goal of this study was to describe the procedural characteristics, strategy selection and associated technical efficiency outcomes for chronic total occlusion (CTO) percutaneous coronary intervention (PCI) right artery (RCA).We examined clinical angiographic characteristics patients who underwent RCA CTO PCI between 2012 2015 at 11 centres in USA. target vessel 739 1,308 PCIs (56%). Overall success rates were 90% 88%, respectively. A major adverse cardiovascular event (MACE) occurred 19...
Lead wire malposition is a known, but rare complication of permanent pacemaker or defibrillator implantation. The actual incidence and prevalence unknown management options for inadvertent left ventricular lead have not been uniform. Current recommendations include systemic anticoagulation with warfarin surgical removal circulatory arrest compelling clinical scenarios. Percutaneous left-sided extraction contraindicated due to the potentially increased risk thromboembolic complications...
Objective To assess the spatial distribution of chronic total occlusions (CTOs) within coronary arteries and describe procedural strategies outcomes during CTO percutaneous intervention (PCI). Background Acute due to plaque rupture tend cluster proximal third artery. Methods We examined clinical characteristics 1,348 patients according lesion location tree. Results A 1,369 lesions in (mean age 66 ± 10 years, 85% male) were included. PCI segments ( n = 633, 46%) was more common than mid 557,...