A5081879012- Coronary Interventions and Diagnostics
- Orthopedic Surgery and Rehabilitation
- Cardiac Imaging and Diagnostics
- Elbow and Forearm Trauma Treatment
- Cerebrovascular and Carotid Artery Diseases
- Peripheral Artery Disease Management
- Ovarian function and disorders
- Cardiac Arrhythmias and Treatments
- Radiation Dose and Imaging
- Atrial Fibrillation Management and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Reproductive Biology and Fertility
- Cardiac electrophysiology and arrhythmias
- Reconstructive Surgery and Microvascular Techniques
- Advanced MRI Techniques and Applications
- Acute Myocardial Infarction Research
- Hypothalamic control of reproductive hormones
- Musculoskeletal synovial abnormalities and treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Vascular Procedures and Complications
- Orthopedic Infections and Treatments
- Bone fractures and treatments
- Electrostatic Discharge in Electronics
- Neuropeptides and Animal Physiology
- Cardiovascular Effects of Exercise
Mayo Clinic
2017-2024
Tzaneion General Hospital
2024
National and Kapodistrian University of Athens
2024
University General Hospital Attikon
2024
London Clinic
2024
University of Ulster
2024
Queen Victoria Hospital
2018-2023
Queen Mary University of London
2018-2023
Rhön-Klinikum
2010-2022
Mayo Clinic in Arizona
2015-2022
Patients with mutations that inactivate kisspeptin signaling are infertile. Kisspeptin-54, the major circulating isoform of in humans, potently stimulates reproductive hormone secretion humans. Animal studies suggest is involved generation luteinizing surge, which required for ovulation; therefore, we hypothesized kisspeptin-54 could be used to trigger egg maturation women undergoing vitro fertilization therapy.Following superovulation recombinant follicle-stimulating and administration...
In vitro fertilization (IVF) treatment is an effective therapy for infertility, but can result in the potentially life-threatening complication, ovarian hyperstimulation syndrome (OHSS).This study aimed to investigate whether kisspeptin-54 be used effectively and safely trigger oocyte maturation women undergoing IVF at high risk of developing OHSS.This was a phase 2, multi-dose, open-label, randomized clinical trial 60 OHSS carried out during 2013-2014 Hammersmith Hospital unit, London,...
Background— The performance of the Japan–chronic total occlusion (J-CTO) score in predicting success and efficiency CTO percutaneous coronary intervention has received limited study. Methods Results— We examined records 650 consecutive patients who underwent between 2011 2014 at 6 experienced centers United States. Six hundred fifty-seven lesions were classified as easy (J-CTO=0), intermediate (J-CTO=1), difficult (J-CTO=2), very (J-CTO≥3). impact J-CTO on technical procedure time was...
Objectives To examine the success and complication rates in percutaneous coronary intervention (PCI) for chronic total occlusions (CTO) caused by in‐stent restenosis (ISR). Background PCI occlusive disease has traditionally been associated with low rates. We sought to angiographic procedural outcomes of patients who underwent CTO due ISR using novel “hybrid” algorithm, compare them de novo CTOs. Methods examined 521 consecutive at five high‐volume centers United States approach. Clinical,...
An artificial intelligence (AI) algorithm applied to electrocardiography during sinus rhythm has recently been shown detect concurrent episodic atrial fibrillation (AF). We sought characterize the value of AI-enabled (AI-ECG) as a predictor future AF and assess its performance compared with CHARGE-AF score (Cohorts for Aging Research in Genomic Epidemiology-AF) population-based sample.
Introduction “Single shot” ablation devices to treat symptomatic atrial fibrillation have been engineered over the last years. Safety and efficacy also includes subclinical complications only detected with esophageal endoscopy or cerebral MRI in asymptomatic patients. We studied acute safety profile of a novel multipolar irrigated RF catheter (nMARQ™ ) . Methods Results Forty‐three patients underwent pulmonary vein isolation (PVI) using device. Patient baseline procedural characteristics...
Abstract Context Polycystic ovary syndrome (PCOS) is the most common cause of anovulation. A key feature PCOS arrest follicles at small- to medium-sized antral stage. Objective and Design To provide further insight into mechanism follicle in PCOS, we profiled (i) gonadotropin receptors; (ii) characteristics aberrant steroidogenesis; (iii) expression anti-Müllerian hormone (AMH) its receptor granulosa cells (GCs) from unstimulated, human small (hSAFs) lutein (GLCs). Setting GCs hSAFs were...
Background The hybrid approach to chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has significantly increased procedural success rates, yet some cases still fail. We sought evaluate the causes of failure in a contemporary CTO PCI registry. Methods examined 380 consecutive patients who underwent CTO‐PCI at 4 high volume centers United States using “hybrid” approach. Clinical, angiographic, complication, and efficiency outcomes were compared between successful failed...
Background— The Radiation Reduction During Cardiac Catheterization Using Real-Time Monitoring study sought to examine the effect of a radiation detection device that provides real-time operator dose reporting through auditory feedback (Bleeper Sv; Vertec Scientific Ltd; Berkshire, UK) on patient and exposure during cardiac catheterization. Methods Results— Between January 2012 May 2014, 505 patients undergoing coronary angiography, percutaneous intervention, or both were randomized use...
The use of an artificial intelligence electrocardiography (AI-ECG) algorithm has demonstrated its reliability in predicting the risk atrial fibrillation (AF) within general population. This study aimed to determine effectiveness AI-ECG score identifying patients with chronic lymphocytic leukemia (CLL) who are at high developing AF. We estimated probability AF based on among CLL extracted from Mayo Clinic database. Additionally, we computed and determined ability predict Among 754 newly...
What are the in vivo and vitro actions of kisspeptin-54 on expression genes involved ovarian reproductive function, steroidogenesis hyperstimulation syndrome (OHSS) granulosa lutein (GL) cells when compared with traditional triggers oocyte maturation? The use as an maturation trigger augmented human GL including, FSH receptor (FSHR), LH/hCG (LHCGR), steroid acute regulatory protein (STAR), aromatase, estrogen receptors alpha beta (ESR1, ESR2), 3-beta-hydroxysteroid dehydrogenase type 2...