A5038946266- Health Systems, Economic Evaluations, Quality of Life
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Prostate Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Transplantation: Methods and Outcomes
- Cardiac electrophysiology and arrhythmias
- Radiomics and Machine Learning in Medical Imaging
- Liver Disease Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Renal and Vascular Pathologies
- Cancer Treatment and Pharmacology
- ECG Monitoring and Analysis
- Mechanical Circulatory Support Devices
- Renal Diseases and Glomerulopathies
- Antiplatelet Therapy and Cardiovascular Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Frailty in Older Adults
- Hepatocellular Carcinoma Treatment and Prognosis
- Chronic Kidney Disease and Diabetes
- Nutrition and Health in Aging
- Magnesium in Health and Disease
- Parathyroid Disorders and Treatments
- Organ Donation and Transplantation
- HER2/EGFR in Cancer Research
Fred Hutch Cancer Center
2024
Seattle University
2024
Cancer Research Center
2024
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2024
University of Michigan–Ann Arbor
2023
Michigan United
2023
Mayo Clinic in Florida
2020-2022
Hospital Universitario Virgen de la Arrixaca
2022
Centro de Investigación en Red en Enfermedades Cardiovasculares
2022
Universidad de Murcia
2022
An artificial intelligence (AI) algorithm applied to electrocardiography during sinus rhythm has recently been shown detect concurrent episodic atrial fibrillation (AF). We sought characterize the value of AI-enabled (AI-ECG) as a predictor future AF and assess its performance compared with CHARGE-AF score (Cohorts for Aging Research in Genomic Epidemiology-AF) population-based sample.
Age, CKD risk factors, and kidney function are associated with larger glomerular volume a higher percentage of globally sclerotic glomeruli. Knowledge how these associations may differ by cortical depth is limited.To investigate glomerulosclerosis across different depths cortex, we studied wedge sections the renal parenchyma from 812 patients who underwent radical nephrectomy (for tumor), separately characterizing glomeruli in superficial (subcapsular), middle, deep (juxtamedullary) regions....
Nephrosclerosis, nephron size, and number vary among kidneys transplanted from living donors. However, whether these structural features predict kidney transplant recipient outcomes is unclear.Our study used computed tomography (CT) implantation biopsy to investigate donated as predictors of death-censored graft failure at three centers participating in the Aging Kidney Anatomy study. We global glomerulosclerosis, interstitial fibrosis/tubular atrophy, artery luminal stenosis, arteriolar...
Abstract Background Eligibility criteria and endpoints for cancer cachexia trials—and whether weight loss should be included—remain controversial. Although most trials enrol patients after initial diagnosis, few studies have addressed well a diagnosis is prognostic. Methods We pooled data from non‐small cell lung prospectively conducted within the Alliance Clinical Trials in Oncology (1998–2008), nationally funded infrastructure. examined (i) availability changes (ii) survival. Results A...
A blood test that enables surveillance for early-stage pancreatic ductal adenocarcinoma (PDAC) is an urgent need. Independent laboratories have reported PDAC biomarkers could improve biomarker performance over CA19-9 alone, but the of previously in combination not known. Therefore, we conducted a coordinated case/control study across multiple using common sets blinded training and validation samples (132 295 plasma samples, respectively) from patients non-PDAC control subjects representing...
Background: Professional guidelines recommend HCC screening in at-risk patients using semi-annual ultrasound with or without alpha-fetoprotein (AFP); however, this strategy has limited effectiveness due to low adherence and sensitivity. Increasing data support the potential role of blood-based biomarker panels, which could improve both aspects. The panel GALAD, comprised sex, age, 3 blood biomarkers (AFP, AFP-L3, des-carboxy prothrombin prothrombin), shown high sensitivity specificity phase...
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and potentially permanent adverse effect of chemotherapeutic agents including taxanes such as paclitaxel platinum-based compounds oxaliplatin carboplatin. Previous studies have suggested that genetics may impact the risk CIPN. We conducted genome-wide association (GWASs) for CIPN in two independent populations who had completed European Organisation Research Treatment Cancer Quality Life Questionnaire (EORTC QLQ)-CIPN20...
Discrepancies between clinicians' assessment of chemotherapy-induced peripheral neuropathy (CIPN) and patient-reported outcomes (PRO) have been described, though the underlying reasons are unknown. Our objective was to identify potential patient-specific factors associated with under-describing CIPN clinicians in women non-metastatic breast cancer treated paclitaxel.Patients enrolled an observational study (n = 60) completed weekly PRO using EORTC CIPN20. Clinician-documented NCI CTCAE were...
Abstract Background: Localized prostate tumors show significant spatial heterogeneity, with regions of high-grade disease adjacent to lower grade disease. Consequently, cancer biopsies are prone sampling bias, potentially leading underestimation tumor grade. To study the clinical, epidemiologic, and molecular hallmarks this phenomenon, we conducted a prospective upgrading: differences in detected between biopsy surgery. Methods: We established prospective, multi-institutional cohort men...
Three sets of criteria (International Society Amyloidosis [ISA], Palladini and Kastritis) were independently developed for staging, progression response to predict renal survival in patients with AL amyloidosis. We evaluated these using a cohort 495 newly diagnosed amyloidosis involvement time event competing risk analysis at baseline, 3, 6 12 months after treatment. Only Kastritis had staging system both predicted higher end stage disease (ESRD) the III vs I but only model was predictive II...
Less is known about the risk factors and outcomes associated with stroke in current era of increasing heart transplantation (HT) being performed older patients. The impact immunosuppression on has not yet been previously studied. We aimed to determine incidence, after HT.We retrospectively analyzed incidence ischemic hemorrhagic strokes all consecutive HT recipients transplanted between 1994 2016 at a single institution.Of 529 patients who underwent HT, 57 (10.7%) developed stroke, 8.1% had...
The number of glomeruli is often used to determine the adequacy a kidney biopsy (eg, at least 10 glomeruli). It assumed that specimens with limited amounts cortex are too imprecise for detection focal pathology.Clinical-pathologic correlation (cross-sectional).Living donors who underwent needle core their time donation.The amount biopsied as determined by either or area on histology.The percentage globally sclerotic glomeruli, density interstitial fibrosis foci, and severity arteriosclerosis...
Abstract Magnesium is an essential element that involved in critical metabolic pathways. A diet deficient magnesium associated with increased risk of developing cancer. Few studies have reported whether a serum level below the reference range (RR) prognosis patients diffuse large B cell lymphoma (DLBCL). Using retrospective approach DLBCL undergoing autologous stem transplant (AHSCT), we evaluated association hypomagnesemia survival. Totally, 581 eligible for AHSCT during immediate...
Abstract A promising approach to the early detection of pancreatic ductal adenocarcinoma (PDAC) is surveillance among people at elevated risk for disease using a blood test. Several groups have reported biomarkers, but no single biomarker delivers rate positively predicting cancers and negatively non-cancers needed routine use. We hypothesized that combinations previously PDAC biomarkers could contribute complementary across heterogeneous subgroups patients consequently improve performance....
A blood test that enables surveillance for early-stage pancreatic ductal adenocarcinoma (PDAC) is an urgent need. Independent laboratories have reported PDAC biomarkers could improve biomarker performance over CA19-9 alone, but the of previously in combination not known. Therefore, we conducted a coordinated case/control study across multiple using common sets blinded training and validation samples (132 295 plasma samples, respectively) from patients non-PDAC control subjects representing...
<p>Supplementary Figure 3 displays supplementary information on ancestry calling, genetically adjusted PSA Density, and polygenic risk scoring.</p>