A5022762690- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Renal cell carcinoma treatment
- Radiomics and Machine Learning in Medical Imaging
- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- Advancements in Transdermal Drug Delivery
- Renal and related cancers
- Molecular Biology Techniques and Applications
- Cancer, Lipids, and Metabolism
- AI in cancer detection
- Health Systems, Economic Evaluations, Quality of Life
- Urologic and reproductive health conditions
- Global Cancer Incidence and Screening
- Cancer Genomics and Diagnostics
- Contact Dermatitis and Allergies
- Urological Disorders and Treatments
- Cancer-related molecular mechanisms research
- Advanced Proteomics Techniques and Applications
- Phagocytosis and Immune Regulation
- Ferroptosis and cancer prognosis
- Glutathione Transferases and Polymorphisms
- Glycosylation and Glycoproteins Research
- Sexual Differentiation and Disorders
- Statistical Methods in Clinical Trials
Stanford University
2016-2025
Stratford University
2011-2025
Palo Alto University
2010-2025
Stanford Medicine
2012-2024
University of South Florida
2017-2024
Florida College
2024
Linde (United States)
2020-2023
John Wiley & Sons (United States)
2015-2023
Hudson Institute
2017-2023
Wabtec (United States)
2023
Prostate cancer, a leading cause of cancer death, displays broad range clinical behavior from relatively indolent to aggressive metastatic disease. To explore potential molecular variation underlying this heterogeneity, we profiled gene expression in 62 primary prostate tumors, as well 41 normal specimens and nine lymph node metastases, using cDNA microarrays containing ≈26,000 genes. Unsupervised hierarchical clustering readily distinguished tumors samples, further identified three...
Hypermethylation of regulatory sequences at the locus pi-class glutathione S-transferase gene GSTP1 was detected in 20 human prostatic carcinoma tissue specimens studied but not normal tissues or exhibiting benign hyperplasia. In addition, a striking decrease expression found to accompany carcinogenesis. Immunohistochemical staining with anti-GSTP1 antibodies failed detect enzyme 88 91 carcinomas analyzed. vitro, limited cancer cell lines containing alleles hypomethylated promoter sequences;...
Remarkably little is known about the transcriptional profiles of human embryonic stem (ES) cells or molecular mechanisms that underlie their pluripotency. To identify commonalties among different pluripotent and to search for clues into genesis germ cell tumors, we compared expression ES lines, tumor lines samples, somatic testicular tissue samples by using cDNA microarray analysis. Hierarchical cluster analysis gene showed five independent clustered tightly together, reflecting highly...
DNA methylation is an epigenetic modification that changes with age in human tissues, although the mechanisms and specificity of this process are still poorly understood. We compared CpG across 283 blood, brain, kidney, skeletal muscle samples using arrays to identify tissue-specific effects.We found age-associated CpGs (ageCGs) both common tissues. Tissue-specific CGs frequently located outside islands decreased methylation, ageCGs show opposite trend. AgeCGs significantly associated...
Clear cell renal carcinoma (ccRCC) is the predominant RCC subtype, but even within this classification, natural history heterogeneous and difficult to predict. A sophisticated understanding of molecular features most discriminatory for underlying tumor heterogeneity should be predicated on identifiable biologically meaningful patterns gene expression. Gene expression microarray data were analyzed using software that implements iterative unsupervised consensus clustering algorithms identify...
BackgroundMultiparametric magnetic resonance imaging (mpMRI) interpreted by experts is a powerful tool for diagnosing prostate cancer. However, the generalizability of published results across radiologists varying expertise has not been verified.ObjectiveTo assess variability in mpMRI reporting and diagnostic accuracy experience routine clinical care.Design, setting, participantsMen who underwent MR-fusion biopsy between 2014–2016. Each MRI scan was read one nine using Prostate Imaging...
Abstract Ferroptosis is a type of programmed cell death induced by the accumulation lipid peroxidation and reactive oxygen species in cells. It has been recently demonstrated that cancer cells are vulnerable to ferroptosis inducers (FIN). However, therapeutic potential FINs prostate preclinical settings not explored. In this study, we demonstrate mediators ferroptosis, solute carrier family 7 member 11, SLC3A2, glutathione peroxidase, expressed treatment-resistant cancer. We further...
Significance Desorption electrospray ionization mass spectrometry imaging (DESI-MSI) is a label-free molecular technique that provides window into the biochemical processes present in benign and malignant prostate tissue. This important both improving understanding of tissue biology achieving rapid cancer diagnosis. We applied DESI-MSI to record lipid, carbohydrate, most importantly, small metabolite images from 54 normal specimens. Several Krebs cycle intermediates were at different...
Outcomes from protocol-directed active surveillance for favorable-risk prostate cancers are needed to support decision-making.
In this study, we found 985 genes that change expression in the cortex and medulla of kidney with age. Some whose transcripts increase abundance age are known to be specifically expressed immune cells, suggesting surveillance or inflammation increases The age-regulated show a similar aging profile medulla, common underlying mechanism for aging. Expression profiles these mark not only age, but also relative health physiology older individuals. Finally, set aging-regulated suggests specific...
Abstract Prostate cancer is clinically heterogeneous, ranging from indolent to lethal disease. Expression profiling previously defined three subtypes of prostate cancer, one (subtype-1) linked favorable behavior, and the others (subtypes-2 -3) with a more aggressive form To explore disease heterogeneity at genomic level, we carried out array-based comparative hybridization (array CGH) on 64 tumor specimens, including 55 primary tumors 9 pelvic lymph node metastases. Unsupervised cluster...
The morphologic distinction between prostate and urothelial carcinoma can be difficult. To identify novel diagnostic markers that may aid in the differential diagnosis of versus carcinoma, we analyzed expression patterns bladder cancer tissues using complementary DNA microarrays. Together with our prior studies on renal neoplasms normal kidney, these suggested gene for placental S100 (S100P) is specifically expressed benign malignant cells. Using tissue microarrays, a polyclonal antiserum...
Candidate gene-based studies have identified a handful of aberrant CpG DNA methylation events in prostate cancer. However, profiles not been compared on large scale between tumor and normal prostate, the mechanisms behind these alterations are unknown. In this study, we quantitatively profiled 95 primary tumors 86 benign adjacent tissue samples for their levels at 26,333 CpGs representing 14,104 gene promoters by using Illumina HumanMethylation27 platform. A 2-class Significance Analysis...
Conventional renal cell carcinoma (cRCC) accounts for most of the deaths due to kidney cancer. Tumor stage, grade, and patient performance status are used currently predict survival after surgery. Our goal was identify gene expression features, using comprehensive profiling, that correlate with survival.Gene profiles were determined in 177 primary cRCCs DNA microarrays. Unsupervised hierarchical clustering analysis segregated cRCC into five subgroups. Expression subgroup correlated long-term...