Cesia A. Marquez
A5079386291- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Cancer, Lipids, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Liver physiology and pathology
- Biological Research and Disease Studies
- Immune cells in cancer
- Cell Adhesion Molecules Research
- Advanced Proteomics Techniques and Applications
- Pancreatitis Pathology and Treatment
The University of Texas Southwestern Medical Center
2021-2024
Prediction of hepatocellular carcinoma (HCC) risk is an urgent unmet need in patients with nonalcoholic fatty liver disease (NAFLD). In cohorts 409 NAFLD from multiple global regions, we defined and validated hepatic transcriptome serum secretome signatures predictive long-term HCC NAFLD. A 133-gene signature, prognostic signature (PLS)–NAFLD, predicted incident over up to 15 years longitudinal observation. High-risk PLS-NAFLD was associated IDO1 + dendritic cells dysfunctional CD8 T...
Background: Accurate non-invasive prediction of long-term hepatocellular carcinoma (HCC) risk in advanced liver fibrosis is urgently needed for cost-effective HCC screening; however, this currently remains an unmet need.Methods: A serum-protein-based prognostic secretome signature (PLSec) was bioinformatically derived from previously validated hepatic transcriptome signatures and optimized 79 patients with fibrosis. We independently PLSec 331 cirrhosis mixed etiologies (validation set 1...
Hepatocellular carcinoma (HCC) mortality rates continue to increase faster than those of other cancer types due high heterogeneity, which limits diagnosis and treatment. Pathological molecular subtyping have identified that HCC tumors with poor outcomes are characterized by intratumoral collagenous accumulation. However, the translational post-translational regulation tumor collagen, is critical outcome, remains largely unknown. Here, we investigate spatial extracellular proteome understand...