A5006681185- Cancer, Lipids, and Metabolism
- Cancer Cells and Metastasis
- Wnt/β-catenin signaling in development and cancer
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Estrogen and related hormone effects
- Cancer, Hypoxia, and Metabolism
- Histone Deacetylase Inhibitors Research
- Adipokines, Inflammation, and Metabolic Diseases
- Ferroptosis and cancer prognosis
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Adenosine and Purinergic Signaling
- Nanoplatforms for cancer theranostics
- Chromatin Remodeling and Cancer
- Prostate Cancer Treatment and Research
- Vascular Anomalies and Treatments
- Lipid metabolism and biosynthesis
- Tryptophan and brain disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Cell Adhesion Molecules Research
The University of Texas Southwestern Medical Center
2022-2025
Texas Tech University Health Sciences Center
2020-2023
Texas Tech University
2019-2023
Morphological evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer is gaining momentum as an immunological biomarker. This experiment evaluates the role TILs distant tumors a measure abscopal effect from cryoablation cancer.BALB/c mice underwent bilateral orthotopic transplant with 4T1-12B (triple-negative) cells. At 2 weeks, left were treated by either resection (standard care group) or (intervention followed right 1 week posttreatment. TIL scores calculated hematoxylin and...
Abstract Background: HCC is the third most common cause of cancer-related death and leading among cirrhotic patients. While several treatments for have been approved, chemopreventive strategies are lacking. Aiming to discover novel therapeutic targets, we combined genome wide transcriptomic analysis liver tissues from patients with advanced disease a cell-based system predicting progression risk. Computational identified peroxiredoxin 2 (PRDX2) as candidate driver hepatocarcinogenesis....
Chronic liver disease and cancer are global health challenges. The role of the circadian clock as a regulator physiology is well established in rodents, however, identity epigenetic regulation rhythmically expressed genes human less studied. Here we unravel rhythmic transcriptome epigenome hepatocytes using male chimeric mice. We identify large number protein coding mice, which includes key transcription factors, chromatin modifiers, critical enzymes. show that hepatitis C virus (HCV)...
Hepatocellular carcinoma (HCC) mortality rates continue to increase faster than those of other cancer types due high heterogeneity, which limits diagnosis and treatment. Pathological molecular subtyping have identified that HCC tumors with poor outcomes are characterized by intratumoral collagenous accumulation. However, the translational post-translational regulation tumor collagen, is critical outcome, remains largely unknown. Here, we investigate spatial extracellular proteome understand...
Abstract Background Dishevelled paralogs (DVL1, 2, 3) are key mediators of Wnt pathway playing a role in constitutive oncogenic signaling influencing the tumor microenvironment. While previous studies showed correlation β-catenin with T cell gene expression, little is known about DVL2 modulating immunity. This study aimed to uncover novel interaction between and HER2-positive (HER2+) breast cancer (BC) regulating immunity disease progression. Methods loss function were performed or without...
Hepatocellular carcinoma (HCC) is a leading cause of death among cirrhotic patients, for which chemopreventive strategies are lacking. Recently, we developed simple human cell-based system modeling clinical prognostic liver signature (PLS) predicting disease progression and HCC risk. In previous study, applied our drug discovery identified captopril, an approved angiotensin converting enzyme (ACE) inhibitor, as candidate compound chemoprevention. Here, explored ACE therapeutic target...
Obesity is a major risk factor for breast cancer (BC). Obesity-related metabolic alterations such as inflammation and overactivation of the adipose renin–angiotensin system (RAS) may contribute to progression BC. Clinically used antihypertensive drugs angiotensin-converting enzyme inhibitors (ACE-I) dietary bioactive components eicosapentaenoic acid (EPA) are known their anti-inflammatory RAS blocking properties. However, whether EPA enhances protective effects ACE-I in lessening adipocyte...
DVL proteins are central mediators of the Wnt pathway and relay complex input signals into different branches signaling network. However, molecular mechanism(s) that regulate DVL-mediated still remains unclear. Here, for first time, we elucidate functional significance three DVL-1 lysines (K/Lys) which subject to post-translational acetylation. We demonstrate K34 Lys residue in DIX domain regulates subcellular localization β-catenin, thereby influencing downstream target gene expression....
Abnormal regulation of DNA methylation and its readers has been associated with a wide range cellular dysfunction. Disruption the normal function contributes to cancer progression, neurodevelopmental disorders, autoimmune disease other pathologies. One reader known be especially important is MeCP2. It acts bridge connects histone modifications regulates many gene targets contributing various diseases; however, much remains unknown about how it malignancy. We others previously described novel...
People living with HIV and who receive antiretroviral therapy have a significantly improved lifespan, compared to the early days without therapy. Unfortunately, persisting viral replication in lungs sustains chronic inflammation, which may cause pulmonary vascular dysfunction ultimate life-threatening Pulmonary Hypertension (PH). The mechanisms involved progression of PH remain unclear. study HIV-PH is limited due lack tractable animal models that recapitulate infection pathobiological...
Abstract Aberrant Wnt signaling contributes to every stage of tumorigenesis from immunosuppression in the tumor microenvironment (TME) and reduced infiltrating lymphocytes (TIL) activity niche modulating several cancer hallmarks such as unrestrained growth, increased neoplastic cell survival, invasion, metastasis. The overactive pathway is critical for progression hence a therapeutic target multiple clinical trials. Dishevelled (DVL)s are major scaffold proteins which relay signals both...
Abstract Introduction: Triple-negative and HER2+ breast cancers (BCs) are high-risk subtypes that spread easily hard to treat. Thus, newer therapeutic approaches can prevent local recurrence metastatic of disease required. Cryoablation, a technique kills tumor cells through rapid freeze/thaw cycles, preserving tumor-associated antigens, is approved treat small low-risk tumors but has not been as successful for BCs. A promising area BC cryoablation research its combinational use with immune...