A5032781834- Advancements in Transdermal Drug Delivery
- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Influenza Virus Research Studies
- Immunotherapy and Immune Responses
- Transgenic Plants and Applications
- Food Allergy and Anaphylaxis Research
- Advanced Drug Delivery Systems
- Ocular Surface and Contact Lens
- Toxin Mechanisms and Immunotoxins
- Plant Reproductive Biology
- Bee Products Chemical Analysis
- Dental Implant Techniques and Outcomes
- Immune Response and Inflammation
- Orthopaedic implants and arthroplasty
- Respiratory viral infections research
- Dental Radiography and Imaging
- Advanced Fluorescence Microscopy Techniques
- Pain Mechanisms and Treatments
- Periodontal Regeneration and Treatments
- Proteins in Food Systems
- Monoclonal and Polyclonal Antibodies Research
- Skin Protection and Aging
- Immune Cell Function and Interaction
Texas Tech University
2016-2025
North Carolina State University
2024-2025
University of North Carolina at Chapel Hill
2025
North Carolina Agricultural and Technical State University
2024
Government of Himachal Pradesh
2020
Universidade Estadual de Campinas (UNICAMP)
2019
Faculdade São Leopoldo Mandic
2019
Emory University
2009-2014
Georgia Institute of Technology
2004-2011
The Wallace H. Coulter Department of Biomedical Engineering
2004-2011
To design microneedles that minimize pain, this study tested the hypothesis cause significantly less pain than a 26-gauge hypodermic needle, and decreasing microneedle length number of reduces in normal human volunteers.
Drugs with poor oral bioavailability usually are administered by hypodermic injection, which causes pain, patient compliance, the need for trained personnel, and risk of infectious disease transmission. Transdermal (TD) delivery provides an excellent alternative, but barrier skin's outer stratum corneum (SC) prevents most drugs. Micrometer-scale microneedles (MNs) have been used to pierce animal human cadaver skin thereby enable TD small molecules, proteins, DNA, vaccines systemic action....
To test the hypothesis that coated microneedles can deliver drugs into eye via intrascleral and intracorneal routes in a minimally invasive manner.Solid metal measuring 500 to 750 microm length were with model drugs, protein, DNA; inserted nonpreserved human cadaveric sclera; imaged. Microneedles sodium fluorescein then rabbit cornea vivo. After needle removal, concentration anterior segment of was measured for 24 hours. Similar experiments performed using pilocarpine-coated microneedles,...
Influenza prophylaxis would benefit from a simple method to administer influenza vaccine into skin without the need for hypodermic needles. In this study, solid metal microneedle arrays (MNs) were investigated as system cutaneous delivery using virus antigen. The MNs with 5 monument-shaped microneedles per array produced and coated inactivated A/PR/8/34 (IIV). As much 10 μg of viral proteins could be onto an microneedles, IIV was delivered at high efficiency within minutes. used immunize...
Aim: This study aimed to develop a novel influenza A vaccine by conjugating the highly conserved extracellular region of matrix 2 protein (M2e) virus gold nanoparticles (AuNPs) and test in mouse challenge model. Materials & methods: Citrate-reduced AuNPs (diameter: 12 nm) were synthesized, characterized transmission electron microscopy dynamic light scattering. M2e was conjugated through thiol–gold interactions form M2e–AuNP conjugates. Particle stability confirmed UV–visible spectra,...
Hypodermic needles are in widespread use, but patients unhappy with the pain, anxiety, and difficulty of using them. To increase patient acceptance, smaller needle diameters lower insertion forces have been shown to reduce frequency painful injections. Guided by these observations, fine microneedles developed minimize pain found greatest utility for delivery vaccines biopharmaceuticals such as insulin. However, reduction must be balanced against limitations injection depth, volume,...