A5100614694- Advancements in Transdermal Drug Delivery
- Dermatology and Skin Diseases
- Ocular Surface and Contact Lens
- Advanced Drug Delivery Systems
- Toxin Mechanisms and Immunotoxins
- Contact Dermatitis and Allergies
- Microfluidic and Capillary Electrophoresis Applications
- Bee Products Chemical Analysis
- Lipid Membrane Structure and Behavior
- 3D Printing in Biomedical Research
- Microfluidic and Bio-sensing Technologies
- Essential Oils and Antimicrobial Activity
- Healthcare Education and Workforce Issues
- Traditional Chinese Medicine Studies
- Neuroscience and Neural Engineering
- Nanoparticle-Based Drug Delivery
- Advanced Fiber Optic Sensors
- Immunotherapy and Immune Responses
- Microbial Inactivation Methods
- Infrared Thermography in Medicine
- Nanomaterials and Printing Technologies
- Botulinum Toxin and Related Neurological Disorders
- Dermatologic Treatments and Research
- Oral Health Pathology and Treatment
- Nanofabrication and Lithography Techniques
Gachon University
2015-2024
Soongsil University
2021
Samsung (South Korea)
2004-2019
Hanyang University Seoul Hospital
2019
Seonam University
2018
Government of the Republic of Korea
2018
Daejeon University
2016
Chung-Ang University
2013
Kyungdong University
2007-2011
Yonsei University
2009-2010
Arrays of micrometer-scale needles could be used to deliver drugs, proteins, and particles across skin in a minimally invasive manner. We therefore developed microfabrication techniques for silicon, metal, biodegradable polymer microneedle arrays having solid hollow bores with tapered beveled tips feature sizes from 1 1,000 μm. When microneedles were used, permeability was increased vitro by orders magnitude macromolecules up 50 nm radius. Intracellular delivery molecules into viable cells...
Administration of protein and DNA biotherapeutics is limited by the need for hypodermic injection. Use micron-scale needles to deliver drugs in a minimally invasive manner provides an attractive alternative, but application this approach suitable microneedle designs fabrication methods. To address need, paper presents conical polymer design that fabricated using novel integrated lens technique analyzed its ability insert into skin without mechanical failure. Microneedle master structures...
A microneedle system has been developed to deliver chemical and biological agents through the stratum corneum, which is main barrier drug delivery. Recently, microneedles have fabricated from various kinds of polymers, including biocompatible polymer, biodegradable water-soluble polymer. Polymer offer benefits ease fabrication, cost-effectiveness, mass production, as well controlled release using water solubility degradation properties In this review, key features polymer are discussed,...
In this study we present the fabrication of multilayer microneedles with circular obelisk and beveled-circular geometries, which have potential applications in implantable drug delivery devices. Micro-milling was adopted as an environmental-friendly cost-effective way to fabricate primary metal microneedle masters. Polylactic acid (PLA) sharp tips were then obtained by micromolding followed oxygen plasma etching used for preparing polydimethylsiloxane (PDMS) molds. A spray deposition process...
A microneedle array patch (MAP) has been developed as a new delivery system for vaccines. Preclinical and clinical trials with vaccine MAP showed improved stability, safety, immunological efficacy compared to conventional administration. Various vaccines can be delivered MAP. Currently, manufacturers mass-produce pharmaceutical cosmetic this mass-production adapted produce Clinical have shown comparable administration, discussions about regulations are underway. However, there concerns of...
Abstract The impact of many biopharmaceuticals, including protein‐ and gene‐based therapies, has been limited by the need for better methods delivery into cells within tissues. Here, intracellular molecules transfection with plasmid DNA electroporation is presented using a novel microneedle electrode array designed targeted treatment skin other tissue surfaces. molded out polylactic acid. Electrodes circuitry required are applied to surface new metal‐transfer micromolding method. maintains...
In this study we present polymeric microneedles composed of multiple layers to control drug release kinetics. Layered were fabricated by spraying poly(lactic-co-glycolic acid) (PLGA) and polyvinylpyrrolidone (PVP) in sequence, characterized mechanical testing ex vivo skin insertion tests. The compression test demonstrated that no noticeable layer separation occurred, indicating good adhesion between PLGA PVP layers. Histological examination confirmed the successfully inserted into indicated...