A5015078320- Mechanical Circulatory Support Devices
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- COVID-19 Clinical Research Studies
- Reproductive System and Pregnancy
- Cancer Immunotherapy and Biomarkers
- Cardiac Valve Diseases and Treatments
- Peripheral Artery Disease Management
- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Health and Medical Research Impacts
- Neuroinflammation and Neurodegeneration Mechanisms
- Infective Endocarditis Diagnosis and Management
- Acute Ischemic Stroke Management
- Immune Response and Inflammation
- Cerebrovascular and Carotid Artery Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac pacing and defibrillation studies
- SARS-CoV-2 and COVID-19 Research
- Cardiac Ischemia and Reperfusion
Duke Medical Center
2024
Duke University
2023-2024
Harvard University
2006-2022
Brigham and Women's Hospital
2021-2022
Thrombolysis in Myocardial Infarction Study Group
2022
Duke University Health System
2022
University of California, San Francisco
2013-2019
Tokushima Bunri University
2006
Immune Regulation (United Kingdom)
2006
University of Birmingham
2006
Normal intestinal mucosa contains abundant immunoglobulin A (IgA)-secreting cells, which are generated from B cells in gut-associated lymphoid tissues (GALT). We show that dendritic (DC) GALT induce T cell-independent expression of IgA and gut-homing receptors on cells. GALT-DC-derived retinoic acid (RA) alone conferred gut tropism but could not promote secretion. However, RA potently synergized with interleukin-6 (IL-6) or IL-5 to Consequently, mice deficient the precursor vitamin lacked...
Cardiogenic shock continues to carry a high mortality rate despite contemporary care, with no breakthrough therapies shown improve survival over the past few decades. It is time-sensitive condition that commonly results in cardiovascular complications and multisystem organ failure, necessitating multidisciplinary expertise. Managing patients cardiogenic remains challenging even well-resourced settings, an important subgroup of may require cardiac replacement therapy. As result, idea...
Abstract Aims We sought to characterize circulating protein biomarkers associated with cardiogenic shock (CS) using highly multiplex proteomic profiling. Methods and results This analysis employed a cross-sectional case–control study design biorepository of patients admitted cardiac intensive care unit between 2017 2020. Cases were adjudicated have CS, controls those presenting for critical without shock, including subsets isolated hypotension or heart failure (HF). The Olink platform was...
The rules by which naïve T cells decide whether and how to respond antigenic stimuli are incompletely understood. Using multiphoton intravital microscopy (MP-IVM) in lymph nodes (LNs), we have shown that CD8 + primed antigen-presenting dendritic (DCs) three consecutive phases. During phase one, undergo brief serial contacts with many DCs for several hours after homing into the LNs. Subsequently, during two, engage prolonged stable interactions DCs. Finally, third phase, return transient as...
Background Early reports from the COVID-19 pandemic identified coronary thrombosis leading to ST-segment-elevation myocardial infarction (STEMI) as a complication of infection. However, epidemiology STEMI in patients with is not well characterized. We sought determine incidence, diagnostic and therapeutic approaches, outcomes hospitalized for COVID-19. Methods Results Patients data on presentation ECG in-hospital were January 14, 2020 November 30, 2020, 105 sites participating American Heart...
Abstract Funding Acknowledgements Type of funding sources: Other. Main source(s): PI funded - Jason Katz, MD Background Temporary MCS devices are routinely used in pts with CS. The most commonly temporary device worldwide is the IABP, which increases DBP, enhances coronary perfusion, and improves cardiac output. No randomized controlled trial has demonstrated its superiority over standard care practices observational data suggest heterogeneity hemodynamic effect. IABP response likely depends...
Background: There are limited data depicting the relationship between frailty and in-hospital outcomes for high-risk PCI. Methods: The Cath-PCI registry (2018 - 2020) was used to examine association of as defined by Canadian Study Health Aging (CSHA) index complications patients undergoing We conducted a logistic regression analysis mortality. Results: sample size 1,316,390 individuals aged ≥ 65 years distribution was: 78,921 not frail (6.0%), 892,695 pre-frail (67.8%), 284,444 (21.6%),...
Introduction: The safety of chest compressions (CC) during cardiopulmonary resuscitation (CPR) among pts with a durable left ventricular assist device (LVAD) is an area controversy. Concerns regarding malfunction or dislodgment CC may result in significant delays the withholding life-sustaining intervention entirely. Current societal guidelines, based on small case reports, suggest that manual are probably not harmful, but offer no additional guidance. Furthermore, they acknowledge there...
Abstract Background: Immune dysregulation has been implicated in the poor outcomes associated with high grade and/or triple negative (Tneg) breast cancers. This suggests that a multi-modal approach to stimulating immune system could be an effective therapeutic strategy for Tneg cancer. However, many immunotherapeutic agents demonstrate significant toxicities when administered systemically at doses. Therefore, we investigated efficacy of local, intratumoral administration immunomodulators...
Abstract Naïve CD8+ T cells are activated through interactions with antigen (Ag) bearing dendritic (DCs) in lymph nodes (LNs). Multiphoton intravital microscopy (MP-IVM) of LNs has demonstrated that cell activation occurs three phases. The duration the initial phase transient, serial DC-T is inversely related to Ag dose. It had been assumed second phase, characterized by stable contacts, necessary for activation, however, here we show this not always case. interacting DCs presenting at low...
Abstract Background. Toll-like receptors (TLR) recognize conserved molecular patterns expressed by microbes and together with other sensors serve as a first line of defense, inducing soluble cellular mediators innate immunity initiating key steps an adaptive immune response. The use TLR agonists for therapeutic purposes relies on the ability these compounds to induce, at least partially, some events that occur during natural infections. For example, synthetic CpG-containing...