A5052318251- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Cardiac Ischemia and Reperfusion
- Cardiac Structural Anomalies and Repair
- Trauma and Emergency Care Studies
- Anesthesia and Neurotoxicity Research
- Animal health and immunology
- Mycotoxins in Agriculture and Food
- Respiratory Support and Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Thermal Regulation in Medicine
- Trauma Management and Diagnosis
- Cardiac, Anesthesia and Surgical Outcomes
- Pharmacological Effects and Assays
- Cardiac electrophysiology and arrhythmias
- Transplantation: Methods and Outcomes
- Heart Rate Variability and Autonomic Control
- Viral gastroenteritis research and epidemiology
- Intensive Care Unit Cognitive Disorders
- Cardiovascular Function and Risk Factors
- Venous Thromboembolism Diagnosis and Management
- Heart Failure Treatment and Management
- Disaster Response and Management
- Microbial infections and disease research
- Neuroscience and Neuropharmacology Research
University of Minnesota
2016-2025
University of Minnesota System
2014-2025
University of Minnesota Medical Center
2018-2024
Northwell Health
2021
University of Utah Hospital
2021
School District of Palm Beach County
2020
Twin Cities Orthopedics
2016-2018
University of Iowa
2004-2012
Stanford University
2008-2011
Stanford Medicine
2010
Veno-arterial extracorporeal membrane oxygenation (ECMO) is increasingly being deployed for selected patients in cardiac arrest who do not attain a native circulation with conventional CPR (ECPR). This ELSO guideline intended to be practical guide implementing ECPR and the early management following establishment of ECMO support. Where paucity high-quality evidence exists, consensus has been reached amongst authors provide guidance clinician. will updated as further this field becomes available.
The likelihood of neurologically favorable survival declines with prolonged resuscitation. However, the ability extracorporeal cardiopulmonary resuscitation (ECPR) to modulate this decline is unknown. Our aim was examine effects duration on and metabolic profile in patients who undergo ECPR for refractory ventricular fibrillation/ventricular tachycardia out-of-hospital cardiac arrest.We retrospectively evaluated 160 consecutive adults arrest treated University Minnesota (UMN) protocol...
Pulmonary embolism (PE) is a life-threatening condition and leading cause of morbidity mortality. There have been many advances in the field PE last few years, requiring careful assessment their impact on patient care. However, variations recommendations by different clinical guidelines, as well lack robust trials, make decisions challenging. The Embolism Response Team Consortium an international association created to advance diagnosis, treatment, outcomes patients with PE. In this...
In 2015, the Minnesota Resuscitation Consortium (MRC) implemented an advanced perfusion and reperfusion life support strategy designed to improve outcome for patients with out-of-hospital refractory ventricular fibrillation/ventricular tachycardia (VF/VT). We report outcomes of initial 3-month period operations.Three emergency medical services systems serving Minneapolis-St. Paul metro area participated in protocol. Inclusion criteria included age 18 75 years, body habitus accommodating...
Refractory out-of-hospital cardiac arrest (OHCA) treated with standard advanced life support (ACLS) has poor outcomes. Transport to hospital followed by in-hospital extracorporeal cardiopulmonary resuscitation (ECPR) initiation may improve We performed a pooled individual patient data analysis of two randomised controlled trials evaluating ECPR based approach in OHCA.The from published (RCTs) were pooled: ARREST (enrolled Aug 2019-June 2020; NCT03880565) and PRAGUE-OHCA March 1, 2013-Oct 25,...
Cardiogenic shock continues to carry a high mortality rate despite contemporary care, with no breakthrough therapies shown improve survival over the past few decades. It is time-sensitive condition that commonly results in cardiovascular complications and multisystem organ failure, necessitating multidisciplinary expertise. Managing patients cardiogenic remains challenging even well-resourced settings, an important subgroup of may require cardiac replacement therapy. As result, idea...
We describe implementation, evaluate performance, and report outcomes from the first program serving an entire metropolitan area designed to rapidly deliver extracorporeal membrane oxygenation (ECMO)-facilitated resuscitation patients with refractory ventricular fibrillation/ventricular tachycardia (VF/VT) out-of-hospital cardiac arrest (OHCA).This observational cohort study analyzed consecutive prospectively enrolled in Minnesota Mobile Resuscitation Consortium's ECMO-facilitated program....
Extracorporeal cardiopulmonary resuscitation is a promising treatment for refractory out-of-hospital cardiac arrest. Three recent randomized trials (ARREST trial, Prague OHCA study, and INCEPTION trial) that addressed the clinical benefit of extracorporeal in arrest yielded seemingly diverging results. The evidence arrest, derived from three controlled trials, not contradictory but rather complementary. Excellent results can be achieved with very high level dedication, provided strict...
Abstract Background There is considerable debate about the hemodynamic effects of veno‐arterial extracorporeal membrane oxygenation (VA‐ECMO). Aims To evaluate changes in left ventricular (LV) function, volumes, and work patients treated with VA‐ECMO using invasive LV catheterization three‐dimensional echocardiographic volumes. Methods Patients on underwent evaluation due to concerns regarding candidacy for decannulation. Hemodynamic parameters were reported as means±standard deviations or...
Proline-rich tyrosine kinase 2 (Pyk2) is a member of the focal adhesion family and highly expressed in brain hematopoietic cells. Pyk2 plays diverse functions cells, including regulation cell adhesion, migration, cytoskeletal reorganization. In brain, it involved induction long term potentiation through N-methyl-d-aspartate receptor trafficking. This occurs phosphorylation activation Src members, such as Fyn, that phosphorylate GluN2B at Tyr(1472). Phosphorylation this site leads to...
It is not know if hospital-level extracorporeal cardiopulmonary resuscitation (ECPR) case volume, or postcannulation clinical management associate with survival outcomes.
The tyrosine kinase Pyk2 plays a unique role in intracellular signal transduction by linking Ca 2+ influx to phosphorylation, but the molecular mechanism of activation is unknown. We report that oligomerization antibodies vitro or overexpression PSD-95 PC6-3 cells induces trans -autophosphorylation Tyr402, first step activation. In neurons, through NMDA-type glutamate receptors causes postsynaptic clustering and autophosphorylation endogenous via - calmodulin-stimulated binding PSD-95....