A5042705916- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Respiratory Support and Mechanisms
- Patient Safety and Medication Errors
- Sepsis Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Healthcare cost, quality, practices
- Hemodynamic Monitoring and Therapy
- Heart Failure Treatment and Management
- Trauma Management and Diagnosis
Maastricht University
2018-2024
Maastricht University Medical Centre
2021-2024
University Hospital and Clinics
2024
University Medical Center
2023-2024
Extracorporeal cardiopulmonary resuscitation (CPR) restores perfusion and oxygenation in a patient who does not have spontaneous circulation. The evidence with regard to the effect of extracorporeal CPR on survival favorable neurologic outcome refractory out-of-hospital cardiac arrest is inconclusive.
Extracorporeal cardiopulmonary resuscitation is a promising treatment for refractory out-of-hospital cardiac arrest. Three recent randomized trials (ARREST trial, Prague OHCA study, and INCEPTION trial) that addressed the clinical benefit of extracorporeal in arrest yielded seemingly diverging results. The evidence arrest, derived from three controlled trials, not contradictory but rather complementary. Excellent results can be achieved with very high level dedication, provided strict...
When out-of-hospital cardiac arrest (OHCA) becomes refractory, extracorporeal cardiopulmonary resuscitation (ECPR) is a potential option to restore circulation and improve the patient's outcome. However, ECPR requires specific materials highly skilled personnel, it unclear whether increased survival health-related quality of life (HRQOL) justify these costs.
Return of spontaneous circulation occurs in less than 10% patients with cardiac arrest undergoing cardiopulmonary resuscitation (CPR) for more 15 minutes. Studies suggest that extracorporeal life support during (ECPR) improves survival rate these patients. These studies, however, are hampered by their non-randomized, observational design and mostly single-center. A multicenter, randomized controlled trial is urgently warranted to evaluate the effectiveness ECPR. We hypothesize early...
Evidence for extracorporeal cardiopulmonary resuscitation (CPR) in refractory out-of-hospital cardiac arrest (OHCA) remains inconclusive. Recently, the INCEPTION-trial, comparing with conventional CPR, found no statistically significant difference neurologically favorable survival. Since protocol deviations were anticipated, a pre-specified per-protocol analysis was foreseen.
Prospective, trial-based data comparing health-related quality of life (HRQoL) in patients surviving out-of-hospital cardiac arrest (OHCA) through extracorporeal cardiopulmonary resuscitation (ECPR) or conventional CPR (CCPR) are scarce. We aimed to determine HRQoL during 1-year after refractory OHCA treated with ECPR and CCPR.
Previously, we performed the multicentre INCEPTION trial, randomizing patients with refractory out-of-hospital cardiac arrest (OHCA) to extracorporeal cardiopulmonary resuscitation (ECPR) or conventional (CCPR). Frequentist analysis showed no statistically significant treatment effect for primary outcome; 30-day survival a favourable neurologic outcome (cerebral performance category score of 1-2). To facilitate probabilistic interpretation results, present Bayesian re-analysis trial.
Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly used as a supportive treatment for refractory out-of-hospital cardiac arrest (OHCA). Still, there paucity of data evaluating favorable and unfavorable prognostic characteristics in patients considered ECPR.
Introduction: When out-of-hospital cardiac arrest (OHCA) becomes refractory, extracorporeal cardiopulmonary resuscitation (ECPR) is a potential option to restore circulation and improve the patient's outcome. However, ECPR requires specific materials highly skilled personnel, it unclear whether increased survival health-related quality of life (HRQOL) justify these costs.Methods: This cost-effectiveness study was part INCEPTION study, multicenter, pragmatic randomized trial comparing...