A5000397597- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Long-Term Effects of COVID-19
- Cardiac Structural Anomalies and Repair
- Diabetes Management and Research
- Airway Management and Intubation Techniques
- Immune Response and Inflammation
- Hemodynamic Monitoring and Therapy
- Pulmonary Hypertension Research and Treatments
- Neonatal Respiratory Health Research
- Heart Failure Treatment and Management
- COVID-19 and Mental Health
- Cardiac and Coronary Surgery Techniques
- Cardiac Ischemia and Reperfusion
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Acute Kidney Injury Research
- COVID-19 Clinical Research Studies
- Neonatal and Maternal Infections
- Hemoglobin structure and function
- Nitric Oxide and Endothelin Effects
Barts Health NHS Trust
2017-2024
Imperial College London
2004-2024
NIHR Newcastle Biomedical Research Centre
2023
Newcastle upon Tyne Hospitals NHS Foundation Trust
2023
University of Oxford
2021-2023
Oxford Health NHS Foundation Trust
2021-2023
St Bartholomew's Hospital
2017-2023
Newcastle University
2023
Newcastle upon Tyne Hospital
2023
University of Leicester
2023
Hyperglycemia is common in critically ill patients, even those without diabetes mellitus. Aggressive glycemic control may reduce mortality this population. However, the relationship between mortality, of hyperglycemia, and administration exogenous insulin unclear.To determine whether blood glucose level or quantity administered associated with reduced patients.Single-center, prospective, observational study 531 patients (median age, 64 years) newly admitted over first 6 months 2002 to an...
XTRACORPOREAL MEMBRANE OXYgenation (ECMO) can support gas exchange independently of mechanical ventilation in patients with severe acute respiratory failure.ECMO may be used either as a rescue intervention or to minimize ventilator-associated lung injury 1 and its associated multiple organ dysfunction, 2 both crucial determinants survival for distress syndrome (ARDS).
The Faculty of Intensive Care Medicine and Society Guideline Development Group have used GRADE methodology to make the following recommendations for management adult patients with acute respiratory distress syndrome (ARDS). British Thoracic supports in this guideline. Where mechanical ventilation is required, use low tidal volumes (<6 ml/kg ideal body weight) airway pressures (plateau pressure <30 cmH
Veno-arterial extracorporeal membrane oxygenation (ECMO) is increasingly being deployed for selected patients in cardiac arrest who do not attain a native circulation with conventional CPR (ECPR). This ELSO guideline intended to be practical guide implementing ECPR and the early management following establishment of ECMO support. Where paucity high-quality evidence exists, consensus has been reached amongst authors provide guidance clinician. will updated as further this field becomes available.
Detailed contemporary knowledge of the characteristics surgical population, national anaesthetic workload, techniques and behaviours are essential to monitor productivity, inform policy direct research themes. Every 3-4 years, Royal College Anaesthetists, as part its National Audit Projects (NAP), performs a snapshot activity survey in all UK hospitals delivering anaesthesia, collecting patient-level encounter data from cases under care an anaesthetist. During November 2021, NAP7,...
<h3>BACKGROUND</h3> A study was undertaken to investigate possible reductions in mortality and/or changes outcome predictive factors patients with the acute respiratory distress syndrome (ARDS) managed a single centre. <h3>METHODS</h3> The prospective observational cohort of two patient populations ARDS. Group 1 comprised 41 enrolled between May 1990 and April 1993, group 2 consisted 78 June 1993 March 1997. end points were various death. <h3>RESULTS</h3> There marked reduction groups (66%...
Lethal necrotizing fasciitis caused by Streptococcus pyogenes is characterized a paucity of neutrophils at the site infection. Interleukin (IL)–8, which important for neutrophil transmigration and activation, can be degraded S. pyogenes. Blood isolates were better able to degrade human IL-8 than throat isolates. Degradation was result single specific cleavage between 59glutamine 60arginine within C-terminal α helix. Cleaved reduced activation migration. IL-8–cleaving activity found in...
Summary The 7th National Audit Project of the Royal College Anaesthetists studied peri‐operative cardiac arrest in UK, a topic importance to patients, anaesthetists and surgeons. Here we report results 12‐month registry, from 16 June 2021 15 2022, focusing on epidemiology clinical features. We reviewed 881 cases arrest, giving an incidence 3 10,000 anaesthetics (95%CI 3.0–3.5 per 10,000). Incidence varied with patient surgical factors. Compared denominator survey activity, patients arrest:...
Complications and critical incidents arising during anaesthesia due to patient, surgical or anaesthetic factors, may cause harm themselves progress more severe events, including cardiac arrest death. As part of the 7th National Audit Project Royal College Anaesthetists, we studied a prospective national cohort unselected patients. Anaesthetists recorded anonymous details all cases undertaken over 4 days at their site through an online survey. Of 416 hospital sites invited participate, 352...
Cardiac arrest in the peri-operative period is rare but associated with significant morbidity and mortality. Current reporting systems do not capture many such events, so there an incomplete understanding of incidence outcomes. As cardiac rare, hospitals may only see a small number cases over long periods, anaesthetists be involved for years. Therefore, large-scale prospective cohort needed to gain deep events leading up arrest, management itself patient Consequently, Royal College...
Summary The 7th National Audit Project of the Royal College Anaesthetists studied peri‐operative cardiac arrest in UK, a topic importance to patients, anaesthetists and surgeons. We report results 12‐month registry phase, from 16 June 2021 15 2022, focusing on management outcomes. Among 881 cases arrest, initial rhythm was non‐shockable 723 (82%) cases, most commonly pulseless electrical activity. There were 665 (75%) patients who survived event 384 (52%) hospital discharge. A favourable...
Summary The Royal College of Anaesthetists' 7th National Audit Project baseline survey assessed knowledge, attitudes, practices and experiences peri‐operative cardiac arrests among UK anaesthetists Anaesthesia Associates. We received 10,746 responses, representing a 71% response rate. In‐date training in adult paediatric advanced life support was reported by 9646 (90%) 7125 (66%) anaesthetists, respectively. There were 8994 (84%) respondents who confident leading arrest, with males more than...
Summary We report the results of Royal College Anaesthetists' 7th National Audit Project organisational baseline survey sent to every NHS anaesthetic department in UK assess preparedness for treating peri‐operative cardiac arrest. received 199 responses from 277 departments, representing a 72% response rate. Adult and paediatric care was provided by 188 (95%) 165 (84%) hospitals, respectively. There no intensive unit on‐site 144 (87%) hospitals caring children, meaning transfer critically...
To investigate differences in cytokine/chemokine release response to lipoteichoic acid (LTA) or lipopolysaccharide (LPS) and contributing cellular mechanisms, order improve understanding of the pathogenesis sepsis.Levels cytokines/chemokines were measured plasma peritoneal lavage fluid 10-week-old male mice (C57/B16) following intraperitoneal injection LTA LPS (250 µg), supernatants murine J774.2 cells, immortalised blood monocytes, isolated human monocytes treated with (0-10 µg/ml). The...
Out-of-hospital cardiac arrest carries a poor prognosis with survival less than 10% in many patient cohorts. Survival is inversely associated duration of resuscitation as external chest compressions do not provide sufficient blood flow to prevent irreversible organ damage during prolonged resuscitation. Extracorporeal membrane oxygenation (ECMO) instituted can normal physiological flows and termed Cardio-Pulmonary Resuscitation (ECPR). ECPR may improve when used in-hospital arrests. This...
A single centre has reported that implementation of an intensive insulin protocol, aiming for tight glycaemic control (blood glucose 4.4 to 6.1 mmol/l), resulted in significant reduction mortality longer stay medical and surgical critically ill patients. Our aim was determine the degree which can be maintained using therapy protocol with computerized decision support identify factors may associated control.At a general adult 22-bed care unit, we implemented mechanically ventilated patients,...