A5045599672- Evolutionary Game Theory and Cooperation
- Cardiac, Anesthesia and Surgical Outcomes
- Evolution and Genetic Dynamics
- Airway Management and Intubation Techniques
- Hemodynamic Monitoring and Therapy
- Mathematical and Theoretical Epidemiology and Ecology Models
- Acute Myeloid Leukemia Research
- Game Theory and Applications
- Parkinson's Disease Mechanisms and Treatments
- Epigenetics and DNA Methylation
- Plant and animal studies
- Acute Lymphoblastic Leukemia research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- DNA and Nucleic Acid Chemistry
- Neurological disorders and treatments
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- RNA modifications and cancer
- Cardiac Arrest and Resuscitation
- Folate and B Vitamins Research
- Bone and Joint Diseases
- Genomics and Rare Diseases
- Parvovirus B19 Infection Studies
- Spinal Fractures and Fixation Techniques
- Genetic Syndromes and Imprinting
Parks and Wildlife Service
2024
University of London
2024
Royal College of Anaesthetists
2022-2023
University College London
2013-2023
Kaiser Permanente
2022
University of Mississippi
2016
Christ University
2016
Princeton University
2012
Harvard University
2004-2009
Evolutionary Genomics (United States)
2007-2009
Detailed contemporary knowledge of the characteristics surgical population, national anaesthetic workload, techniques and behaviours are essential to monitor productivity, inform policy direct research themes. Every 3-4 years, Royal College Anaesthetists, as part its National Audit Projects (NAP), performs a snapshot activity survey in all UK hospitals delivering anaesthesia, collecting patient-level encounter data from cases under care an anaesthetist. During November 2021, NAP7,...
How does natural selection lead to cooperation between competing individuals? The Prisoner's Dilemma captures the essence of this problem. Two players can either cooperate or defect. payoff for mutual cooperation, R, is greater than defection, P. But a defector versus cooperator receives highest payoff, T, where as obtains lowest S. Hence, defined by ranking T > R P In well-mixed population, defectors always have higher expected cooperators, and therefore favors defectors. evolution requires...
Summary The 7th National Audit Project of the Royal College Anaesthetists studied peri‐operative cardiac arrest in UK, a topic importance to patients, anaesthetists and surgeons. Here we report results 12‐month registry, from 16 June 2021 15 2022, focusing on epidemiology clinical features. We reviewed 881 cases arrest, giving an incidence 3 10,000 anaesthetics (95%CI 3.0–3.5 per 10,000). Incidence varied with patient surgical factors. Compared denominator survey activity, patients arrest:...
Complications and critical incidents arising during anaesthesia due to patient, surgical or anaesthetic factors, may cause harm themselves progress more severe events, including cardiac arrest death. As part of the 7th National Audit Project Royal College Anaesthetists, we studied a prospective national cohort unselected patients. Anaesthetists recorded anonymous details all cases undertaken over 4 days at their site through an online survey. Of 416 hospital sites invited participate, 352...
Cardiac arrest in the peri-operative period is rare but associated with significant morbidity and mortality. Current reporting systems do not capture many such events, so there an incomplete understanding of incidence outcomes. As cardiac rare, hospitals may only see a small number cases over long periods, anaesthetists be involved for years. Therefore, large-scale prospective cohort needed to gain deep events leading up arrest, management itself patient Consequently, Royal College...
Summary The 7th National Audit Project of the Royal College Anaesthetists studied peri‐operative cardiac arrest in UK, a topic importance to patients, anaesthetists and surgeons. We report results 12‐month registry phase, from 16 June 2021 15 2022, focusing on management outcomes. Among 881 cases arrest, initial rhythm was non‐shockable 723 (82%) cases, most commonly pulseless electrical activity. There were 665 (75%) patients who survived event 384 (52%) hospital discharge. A favourable...
Summary The Royal College of Anaesthetists' 7th National Audit Project baseline survey assessed knowledge, attitudes, practices and experiences peri‐operative cardiac arrests among UK anaesthetists Anaesthesia Associates. We received 10,746 responses, representing a 71% response rate. In‐date training in adult paediatric advanced life support was reported by 9646 (90%) 7125 (66%) anaesthetists, respectively. There were 8994 (84%) respondents who confident leading arrest, with males more than...
Summary We report the results of Royal College Anaesthetists' 7th National Audit Project organisational baseline survey sent to every NHS anaesthetic department in UK assess preparedness for treating peri‐operative cardiac arrest. received 199 responses from 277 departments, representing a 72% response rate. Adult and paediatric care was provided by 188 (95%) 165 (84%) hospitals, respectively. There no intensive unit on‐site 144 (87%) hospitals caring children, meaning transfer critically...
SUMMARY A sensitive and specific radioimmunoassay for α-melanocyte-stimulating hormone (α-MSH) was developed. Extracts of the neurointermediate lobe rat produced displacement curves which were parallel to those obtained with synthetic α-MSH. The mean immunoreactive a-MSH concentration in lobes from normal adult rats 2768 ± 200 ( s.e.m. ) ng/lobe. This accounted approximately 78% MSH activity as measured by bioassay. Much lower levels α-MSH found anterior rat. serum plasma also contained...
Cognitive stimulation therapy (CST) is widely used with people dementia, but there no evidence of its efficacy in mild cognitive impairment or dementia Parkinson’s disease (PD-MCI; PDD) Lewy bodies (DLB). We aimed to explore the impact ‘CST-PD’, which home-based, individualized CST adapted for this population. In a single-blind, randomized controlled exploratory pilot trial (RCT), we 76 participant–dyads [PD-MCI ( n = 15), PDD 40), DLB 21) and their care partners] CST-PD treatment as usual...
Drug-based therapeutic approaches for Parkinson's disease dementia (PDD) and with Lewy bodies (DLB) are moderately effective not always tolerated. Tailoring psychosocial in PDD DLB may offer additional support improve outcomes. We adapted home-based, care partner-delivered Cognitive Stimulation Therapy (CST) individuals or their partners (CST-PD).To evaluate the feasibility, acceptability, tolerability of CST-PD.This randomised controlled trial used mixed methods, including a process...
The objective of this study was to evaluate the safety prenatal tetanus, diphtheria, acellular pertussis (Tdap) vaccination. This cohort conducted among pregnant members at Kaiser Permanente Southern California (KPSC). exposed consisted women who received Tdap vaccine on or after 27th week pregnancy between January 2018 and 2019. unexposed matched were 2012 December 2014 not vaccinated with any throughout their pregnancy. Maternal infant characteristics pre-specified endpoints collected...
Major surgery accounts for a substantial proportion of health service activity, due not only to the primary procedure, but longer-term implications poor short-term outcome. Data from small studies or outside UK indicate that rates complications and failure rescue vary between hospitals, as does compliance with best practice processes. Within UK, there is currently no system monitoring postoperative (other than mortality) in major non-cardiac surgery. Further, variation national audit...
Background A condition is defined as rare if it affects fewer than 1 in 2000 people the general population. Limited evidence suggests that care poorly co-ordinated for affected by conditions. Objectives To investigate and how of with conditions UK, would like to be co-ordinated. Design mixed-methods study comprising (1) a scoping review develop definition identify components ( n = 154 studies); (2) an exploratory qualitative interview understand impact lack 15 participants); (3) national...
The cloning and overexpression of the MspI DNA methyltransferase as a functional fusion with glutathione S-transferase is described. enzyme retains full biological activity has been used to investigate interaction substrates inhibitors methyltransferase. purified homogeneity in single step on GSH-agarose free from contaminating exonuclease activity. can be photolabelled S-adenosyl-L-methionine level incorporation label enhanced by presence nonspecific duplex. In cognate oligodeoxynucleotide,...
Poorly coordinated care can have major impacts on patients and families affected by rare conditions, with negative physical health, psychosocial financial consequences. This study aimed to understand how is for diseases in the United Kingdom.We undertook a national survey UK involving 760 adults diseases, 446 parents/carers of people 251 healthcare professionals who diseases.Findings suggested that wide range patients, parents carers do not care. For example, few participants reported having...