A5087905370- Dementia and Cognitive Impairment Research
- Parkinson's Disease Mechanisms and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Geriatric Care and Nursing Homes
- Hearing Loss and Rehabilitation
- Neurological disorders and treatments
- Delphi Technique in Research
- Autism Spectrum Disorder Research
- Mental Health and Patient Involvement
- Health disparities and outcomes
- Noise Effects and Management
- Genetic Neurodegenerative Diseases
- Intergenerational Family Dynamics and Caregiving
- Technology Use by Older Adults
- Health, Environment, Cognitive Aging
- Urban Green Space and Health
- Family and Disability Support Research
- Mental Health and Psychiatry
- COVID-19 and Mental Health
- Psychiatric care and mental health services
- Cognitive Functions and Memory
- Obsessive-Compulsive Spectrum Disorders
- Clinical practice guidelines implementation
- Diet and metabolism studies
- Stroke Rehabilitation and Recovery
Trinity College Dublin
2019-2025
Global Brain Health Institute
2019-2025
University of California, San Francisco
2021-2025
St. James's Hospital
2023-2024
Mercer (Czechia)
2024
Adolfo Ibáñez University
2024
Trinity College London
2024
University of Manchester
2014-2023
Greater Manchester Mental Health NHS Foundation Trust
2006-2022
Nia Association
2022
To compare quality of life, level disability, and caregiver burden in 3 groups people with Parkinson disease (PD): those mild cognitive impairment (PD-MCI), dementia (PDD), no (PD-NC).Although the profile PD-MCI PDD has been well described, little is known about personal clinical impact its on caregivers.Quality life disability were measured participants PD (PD-NC, n=54; PD-MCI, n=48; PDD, n=25). The group was classified using Movement Disorder Society Task Force consensus criteria....
The COVID-19 global pandemic and subsequent public health social measures have challenged our economic life, with increasing concerns around potentially rising levels of isolation loneliness. This paper is based on cross-sectional online survey data (available in 10 languages, from 2 June to 16 November 2020) 20,398 respondents 101 different countries. It aims help increase understanding the risk factors that are associated loneliness, irrespective culture or country, support evidence-based...
Abstract Objective To evaluate the efficacy and safety of donepezil, an acetylcholinesterase inhibitor, as a treatment for cognitive impairment dementia in patients with Parkinson' s disease (PD). Methods Using randomized, double‐blind, placebo‐controlled design, nine received placebo seven donepezil (2.5–10 mg/day) mean (SD) duration 15.2 (3.4) weeks. The primary outcomes were derived from neuropsychological battery that assessed global status well memory, attention, psychomotor speed,...
Background The neuropsychiatric complications of Parkinson's disease (PD), which include behaviour disturbances such as apathy and the impulse control disorders (ICDs), may have a significant effect on patients with PD their carers. contribution these to carer burden is less understood. Therefore, aim this study was explore relationship that ICDs burden. Methods Non‐demented ( n = 71) PD–carer dyads (spouse or adult child) participated in study. participants were divided into three...
Cognitive stimulation therapy (CST) is a well-established group psychosocial intervention for people with dementia. There evidence that home-based programmes of cognitive delivered by family caregivers may benefit both the person and caregiver. However, no previous studies have evaluated caregiver-delivered CST. This study aimed to evaluate effectiveness home-based, caregiver-led individual (iCST) program in (i) improving cognition quality life (QoL) dementia (ii) mental physical health...
The objective of this study is to investigate the safety and tolerability memantine, a glutamatergic modulator, in patients suffering from dementia associated with Parkinson's disease (PDD), an increasingly common complication PD. This was 22-week trial 25 participants DSM-IV diagnosis PDD who were randomized either placebo or 20 mg/day memantine. Memantine well tolerated by at dosing. No participant withdrawn due memantine-related adverse events. Six weeks after drug withdrawal,...
Lithium has neuroprotective effects in cell and animal models of amyotrophic lateral sclerosis (ALS), a small pilot study patients with ALS showed significant effect lithium on survival. We aimed to assess whether improves survival ALS.The carbonate (LiCALS) trial is randomised, double-blind, placebo-controlled oral taken daily for 18 months ALS. Patients aged at least years who had according the revised El Escorial criteria, disease duration between 6 36 months, were taking riluzole...
To determine whether individual goal-oriented cognitive rehabilitation (CR) improves everyday functioning for people with mild-to-moderate dementia.
We aimed to determine whether self-assessed single (hearing or visual) and dual sensory impairments are associated with cognitive decline incident possible impairment, no dementia (CIND) probable dementia.Data were drawn from the 1996-2014 surveys of Health Retirement Study (HRS), involving 19,618 respondents who had aged 50 years older at baseline. used linear mixed models test association between impairment followed by a Cox proportional hazard model estimate relative risk CIND presence...
Background Group cognitive stimulation therapy programmes can benefit cognition and quality of life for people with dementia. Evidence home-based, carer-led interventions is limited. Objectives To evaluate the clinical effectiveness cost-effectiveness carer-delivered individual (iCST) dementia their family carers, compared treatment as usual (TAU). Design A multicentre, single-blind, randomised controlled trial assessing cost-effectiveness. Assessments were at baseline, 13 weeks 26 (primary...
Background Cognitive rehabilitation (CR) is an individualised, person-centred intervention for people with mild to moderate dementia that addresses the impact of cognitive impairment on everyday functioning. Objectives To determine whether or not CR a clinically effective and cost-effective Alzheimer’s disease vascular mixed dementia, their carers. Design This multicentre randomised controlled trial compared treatment as usual (TAU). Following baseline assessment goal-setting identify areas...
Background: There is increasing evidence that people in the early stages of Alzheimer's disease (AD) have subtle impairments cognitive inhibition can be detected by using relatively simple eye-tracking paradigms, but these are often missed traditional assessments.People with mild impairment (MCI) at an increased likelihood dementia due to AD.No study has yet investigated and contrasted MCI subtypes relation eye movement performance.Methods: In this work we explore whether distinguish between...
Hearing impairment is common among older adults and affects cognitive assessments for identification of dementia which rely on good hearing function. We developed validated a version the Montreal Cognitive Assessment (MoCA) people with impairment.We adapted existing MoCA 8.1 items by presenting instructions stimuli in written rather than spoken format. One Attention domain two Language required substitution alternative items. Three four candidate respectively were constructed field-tested...