A5005914276- Dementia and Cognitive Impairment Research
- Geriatric Care and Nursing Homes
- Neonatal Respiratory Health Research
- Health Systems, Economic Evaluations, Quality of Life
- Infant Development and Preterm Care
- Diabetes Management and Research
- Endometrial and Cervical Cancer Treatments
- Assisted Reproductive Technology and Twin Pregnancy
- Adolescent Sexual and Reproductive Health
- Evaluation and Performance Assessment
- Diabetes Management and Education
- Ovarian cancer diagnosis and treatment
- Adolescent and Pediatric Healthcare
- Mobile Health and mHealth Applications
- Folate and B Vitamins Research
- Maternal and Perinatal Health Interventions
- Clinical practice guidelines implementation
- Cerebral Palsy and Movement Disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Health, psychology, and well-being
- Diabetes Treatment and Management
- Meta-analysis and systematic reviews
- Endometriosis Research and Treatment
- Palliative Care and End-of-Life Issues
- Salivary Gland Disorders and Functions
Takeda (United States)
2025
Betsi Cadwaladr University Health Board
2021
University of Exeter
2017
Institute of Mental Health
2017
University of Nottingham
2017
Bangor University
2006-2016
Keele University
2015
Weatherford College
2006
Ysbyty Gwynedd Hospital NHS Trust
2005
King's College London
2005
<h3>Abstract</h3> <b>Objective</b> To test whether steroids reduce respiratory distress in babies born by elective caesarean section at term. <b>Design</b> Multicentre pragmatic randomised trial. <b>Setting</b> 10 maternity units. <b>Participants</b> 998 consenting women decision to deliver section; 503 treatment group. <b>Interventions</b> The group received two intramuscular doses of 12 mg betamethasone the 48 hours before delivery. control as usual. <b>Outcome measures</b> primary outcome...
<h3>Objectives</h3> To determine whether antenatal betamethasone prior to elective term caesarean section (CS) affects long behavioural, cognitive or developmental outcome, and the risk of asthma atopic disease is reduced. <h3>Design</h3> A questionnaire based follow-up a multicentre randomised controlled trial (Antenatal Steroids for Term Elective Caesarean Section, BMJ 2005). <h3>Setting</h3> Four UK study centres from original trial. <h3>Participants</h3> 862 participants four largest...
Background Cognitive rehabilitation (CR) is an individualised, person-centred intervention for people with mild to moderate dementia that addresses the impact of cognitive impairment on everyday functioning. Objectives To determine whether or not CR a clinically effective and cost-effective Alzheimer’s disease vascular mixed dementia, their carers. Design This multicentre randomised controlled trial compared treatment as usual (TAU). Following baseline assessment goal-setting identify areas...
Preliminary evidence suggests that goal-oriented cognitive rehabilitation (CR) may be a clinically effective intervention for people with early-stage Alzheimer's disease, vascular or mixed dementia and their carers. This study aims to establish whether CR is cost-effective In this multi-centre, single-blind randomised controlled trial, 480 dementia, each carer, will receive either treatment as usual (10 therapy sessions over 3 months, followed by 4 maintenance 6 months). We compare the...
Background Very few interventional studies have directly examined the impact of treatment approaches on health-related quality life (HRQL) in people with dementia. This is particular importance therapies to address behavioural symptoms, where HRQL often severely affected. Methods Analysis within WHELD cluster randomised factorial study 16 UK care homes examining person-centred combination antipsychotic review, social interaction and exercise interventions. analysed through DEMQOL-Proxy....
Objectives. To assess the prevalence of abnormal smell and taste perception in people with primary SS effect on quality life (QoL).
Summary A questionnaire survey examining rapid sequence induction techniques was sent to all anaesthetists in Wales. The presented five common clinical scenarios: emergency appendicectomy; elective knee arthroscopy with a symptomatic hiatus hernia; an asymptomatic Caesarean section; and laparotomy for bowel obstruction. Completed surveys were received from 421 anaesthetists, 68% response rate. Rapid chosen by 398/400 respondents (100%) obstruction, 392/399 (98%) section, 388/408 (95%)...
The extent to which care home residents with severe dementia show awareness is influenced by the environment provides opportunities for engagement and way in staff interact them. We aimed establish whether training observe identify signs of resulted improved quality life residents.In this pilot cluster randomized trial, four homes (n = 32) received supervision carried out structured observations using AwareCare measure over an eight-week period, while control 33) had no regard their contact...
Background Folate deficiency is associated with depression. Despite the biological plausibility of a causal link, evidence that adding folate enhances antidepressant treatment weak. Objectives (1) Estimate clinical effectiveness and cost-effectiveness folic acid as adjunct to medication (ADM). (2) Explore whether baseline homocysteine predict response treatment. (3) Investigate depends on genetic polymorphisms related metabolism. Design FolATED (Folate Augmentation Treatment – Evaluation for...
Ozone is a major environmental pollutant inducing severe pulmonary damages. We have compared the effect of ozone on mice subjected to acute (1 ppm, 1 h) and chronic (1.5 h, twice weekly for 6 weeks) exposure. Our investigations focused lesions lung tissue, inflammation hyperreactivity using both conventional methods, novel digital imaging histological approach based machine learning programs. Acute exposure caused disruption in respiratory epithelium with leakage protein recruitment...
Objective To establish a baseline of national practice for follow-up after treatment gynaecological cancer. Design Questionnaire survey. Setting Gynaecological cancer centres and units. Geographical location UK. Participants Members the British Cancer Society National Forum Oncology Nurses. Interventions A questionnaire Outcome measures determine schedules follow-up, who provides it what routine testing is used patients have had previous Results total 117 responses were obtained; 115 (98%)...
Aim To perform a systematic review establishing the current evidence base for physical activity and exercise interventions that promote health, fitness well-being, rather than specific functional improvements, children who use wheelchairs. Design A using mixed methods design. Data sources wide range of databases, including Web Science, PubMed, BMJ Best Practice, NHS EED, CINAHL, AMED, NICAN, PsychINFO, were searched quantitative, qualitative health economics evidence. Eligibility...
In-hospital progressive resistance training (PRT) has been shown to be an effective method of rehabilitation following hip surgery. The aim this study was assess whether a home-based PRT program would beneficial in improving patients' muscle strength and physical function compared standard rehabilitation. Subjects (n = 49) either received 25) or 24) prospective single blinded randomized trial carried out over two-year period. primary outcome measure the maximal voluntary contraction operated...
The prevalence of hepatitis C (HCV) is elevated within prison populations, yet diagnosis in prisons remains low. Dried blood spot testing (DBST) a simple procedure for the detection HCV antibodies; its impact on context unknown.We carried out stepped-wedge cluster-randomized control trial DBST among prisoners five male and one female prison. Each was separate cluster. order which intervention (training use logistic support) introduced randomized across clusters. outcome measure rate by...
Little is known about the quality of life people with very severe dementia in long-term care settings, and more information needed properties measures aimed at this group. In study we explored profiles generated through proxy ratings by staff family members using Quality Life Late-stage Dementia (QUALID) scale, examined factors associated these ratings, further investigated psychometric QUALID. Proxy QUALID were obtained for 105 residents dementia, categorised as meeting criteria Functional...
Abstract Signs of sensory and perceptual awareness can be observed in people with very severe dementia, may influenced by the extent to which environment offers appropriate stimulation. We developed an observational tool, AwareCare, care staff use identify signs residents based on concept Wessex Head Injury Matrix (WHIM). Using WHIM items as a guide, following focus groups family members, expert panel identified 28 environmental stimuli 35 response categories for initial version AwareCare....
However to date there has been no systematically recordeddata on pregnancy and outcomes amongst looked after chil-dren. Local authority data from England is available onmotherhood status but does not record pregnancies ending interminations.Unintended intended teenage conceptions may haveconsiderable impacts the health well being of teenageparents children.
People with dementia living in care homes often have complex mental health problems, disabilities and social needs. Providing more comprehensive training for staff working home environments is a high national priority. It important that this evidence based delivers improvement people residing these environments. Well-being Health Dementia (WHELD) combines the most effective elements of existing approaches to develop but practical intervention. This optimised intervention on factorial study...