A5090230127- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Inflammatory Bowel Disease
- Aortic aneurysm repair treatments
- COVID-19 Clinical Research Studies
- Microscopic Colitis
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Long-Term Effects of COVID-19
- Intraoperative Neuromonitoring and Anesthetic Effects
- Shoulder and Clavicle Injuries
- Shoulder Injury and Treatment
- Respiratory Support and Mechanisms
- Orthopedic Infections and Treatments
- Pelvic and Acetabular Injuries
- Congenital Heart Disease Studies
- Transplantation: Methods and Outcomes
- Cardiac pacing and defibrillation studies
- Eosinophilic Esophagitis
- Celiac Disease Research and Management
- Fuel Cells and Related Materials
- Blood transfusion and management
University of Freiburg
2016-2025
University Medical Center Freiburg
2022-2025
Universitäts-Herzzentrum Freiburg-Bad Krozingen
2017-2025
Eli Lilly (United States)
2023-2025
BG Klinik Tübingen
2022-2024
University Hospital in Halle
2022
Karlsruhe Institute of Technology
2022
Kreiskliniken Reutlingen
2019
Heidelberg University
2009
University Hospital Heidelberg
2009
We sought to clarify the benefit of cytokine adsorption in patients with COVID-19 supported venovenous extracorporeal membrane oxygenation (ECMO).We did a single-centre, open-label, randomised, controlled trial investigate adult severe pneumonia requiring ECMO. Patients selected for ECMO at Freiburg University Medical Center (Freiburg, Germany) were randomly assigned (1:1) receive using CytoSorb device or not. Randomisation was computer-generated, allocation concealed by opaque, sequentially...
The novel coronavirus SARS-CoV-2 and the resulting disease COVID-19 causes pulmonary failure including severe courses requiring venovenous extracorporeal membrane oxygenation (V-V ECMO). Coagulopathy is a known complication of leading to thrombotic events embolism. It unclear if coagulopathy also increases circuit complications ECMO. Aim present study therefor was investigate rate V-V ECMO in COVID-19. We conducted retrospective registry all patients on treated at our centre between 01/2018...
ABSTRACT Introduction Veno‐venous extracorporeal membrane oxygenation (V‐V ECMO) is increasingly used in the treatment of severe respiratory failure. Despite a significant increase worldwide use lung assist devices recirculation remains common complication and associated with reduced effectiveness ECMO support increased hemolysis. In this observational study we aimed to investigate impact cannula configuration flow on recirculation. Materials Methods An retrospective was performed, which...
Abstract Aims Worldwide applications of extracorporeal circulation for mechanical support in cardiac and circulatory failure, which are referred to as life (ECLS) or veno‐arterial membrane oxygenation (va‐ECMO), have dramatically increased over the past decade. In spite expanding use immense medical well socio‐economic impact this therapeutic approach, there has been a lack interdisciplinary recommendations considering best available evidence ECLS treatment. Methods Results...
Abstract Background Mirikizumab (MIRI), an anti-IL-23p19 antibody, has demonstrated efficacy and safety in adults with moderately to severely active ulcerative colitis (UC) two Phase 3 trials (LUCENT-1/-2; NCT03518086, NCT03524092). [1] As novel therapies for UC are not well studied ≥60 years (older adults), we aimed evaluate the of MIRI compared placebo (PBO) during induction maintenance treatment among this especially vulnerable subgroup patients UC. [2. 3] Methods In LUCENT-1, were...
Abstract Background Venovenous extracorporeal membrane oxygenation (VV ECMO) is an established support option for patients with very severe respiratory failure and played important role during the coronavirus disease 2019 (COVID-19) pandemic. Bacteria fungi can lead to infectious complications in critically ill patients. The aim of this study was describe microbiological spectrum bacteria detected COVID-19-associated supported VV ECMO our center. Methods This retrospective single-center...
Left ventricular assist device (LVAD) outflow graft obstruction (OGO) is a serious complication that often requires surgical intervention. Standard approaches involve cardiopulmonary bypass (CPB) or veno-arterial extracorporeal membrane oxygenation (vaECMO) to facilitate clamping and shortening. We present approach reduce the need for CPB vaECMO A 25-year-old female presented routine LVAD follow-up with reduced flow. Computed tomography angiography (CTA) revealed OGO due external compression...
Background To assess risks and benefits of a standardized strategy to prevent symptomatic spinal cord ischemia (SSCI) after thoracic endovascular repair (TEVAR) using routine cerebrospinal fluid (CSF) catheter placement evoked potential (EP) monitoring. Methods One hundred ninety-five patients underwent 223 SSCI low-risk TEVAR procedures between 1998 2014. CSF was used measure pressure drain if necessary throughout the procedure up 24 hours thereafter. EPs were monitor integrity procedure....
Implants made of various types material can be used for the internal fixation fractures. Carbon fiber reinforced polyetheretherketone (CFR-PEEK) is a radiolucent that may have advantageous handling properties compared with titanium implants.Seventy-six patients proximal humerus fractures requiring surgery were randomized to receive fixed-angle plate out either or CFR- PEEK. To measure functional outcome, DASH score (Disabilities Arm, Shoulder, and Hand; primary endpoint), Simple Shoulder...
In contrast to the standard cardioplegic cardiac arrest (CA), some centers prefer beating-heart technique using selective normothermic myocardial perfusion (SMP) during aortic arch repair. The aim of this study was evaluate injury and need for inotropic vasopressor support in patients undergoing total replacement SMP or CA repair.Total performed 127 (65 years [IQR: 56-73 years] years) between March 2013 May 2018 via frozen elephant trunk technique. Of those, 25 were operated on with...
Anterior radiculomedullary arteries (ARMAs) link dorsal segmental and the intraspinal compartment of spinal collateral network. The number thoracic ARMA is highly variable from one person to another. impact ARMAs on cord perfusion during aortic procedures unknown. We investigated influence in an surgical large animal model.Twenty-six pigs were included (20 treatment animals, 6 sham weight 34 ± 3 kg). animals underwent ligation left subclavian artery via a lateral thoracotomy with...
Despite increasing knowledge about the optimal treatment for patients with severe COVID-19, data from different cohorts suggested that survival of treated ECMO seemed to decline over course pandemic.In this non-interventional retrospective single-center registry study we analyzed all consecutive tested positive SARS-CoV-2 infection and supported VV in our center during first three waves pandemic. From March 2020 through June 2021, 59 have been included.Overall 90-day was 32%. Besides changes...
A novel accessory directing the blood from outflow of a left ventricular assist device (LVAD) back through apex and across aortic valve allows LVAD implantation via solely but may affect performance. We quantified effect on flow pressure head in vitro. In mock circulatory loop, centrifugal-flow (HeartMate 3, Abbott, Abbott Park, IL, USA) with (Accessory) without (Control) was compared under physiological conditions using water/glycerol solution as substitute. The pump operated at 4000, 5200,...
Abstract Background The safety and efficacy of mirikizumab (miri), an anti-IL-23p19 antibody, for moderately-to-severely active ulcerative colitis (UC) have been shown in Phase 3 trials (LUCENT-1 -2; NCT03518086, NCT03524092).1 Extended induction with additional intravenous (IV) doses miri induced clinical response at Week (W)24 more than 50% patients who did not initially achieve to W12.2 Among the non-responders, some had achieved partial W12 (Table 1). We assessed over time non-responders...