A5033626510- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Myocardial Infarction Research
- Cardiac Ischemia and Reperfusion
- Pulmonary Hypertension Research and Treatments
- Cardiac and Coronary Surgery Techniques
- Congenital Heart Disease Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood transfusion and management
- Cardiovascular Function and Risk Factors
- Venous Thromboembolism Diagnosis and Management
- Heart Failure Treatment and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Hemodynamic Monitoring and Therapy
- Blood Coagulation and Thrombosis Mechanisms
- Sepsis Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Kidney Injury Research
- Respiratory Support and Mechanisms
- Magnesium in Health and Disease
- Optical Imaging and Spectroscopy Techniques
- Atrial Fibrillation Management and Outcomes
University of Southern Denmark
2021-2025
Odense University Hospital
2017-2025
Rigshospitalet
2015-2024
Copenhagen University Hospital
2016-2024
Aarhus University Hospital
2007-2024
University of Copenhagen
2016-2024
University Medical Center Hamburg-Eppendorf
2024
Universität Hamburg
2024
Heinrich Heine University Düsseldorf
2024
Düsseldorf University Hospital
2024
The effects of temporary mechanical circulatory support with a microaxial flow pump on mortality among patients ST-segment elevation myocardial infarction (STEMI) complicated by cardiogenic shock remains unclear.
Background Cardiogenic shock (CS) is a heterogeneous syndrome with varied presentations and outcomes. We used machine learning approach to test the hypothesis that patients CS have distinct phenotypes at presentation, which are associated unique clinical profiles in‐hospital mortality. Methods Results analyzed data from 1959 2 international cohorts: CSWG (Cardiogenic Shock Working Group Registry) (myocardial infarction [CSWG‐MI; n=410] acute‐on‐chronic heart failure [CSWG‐HF; n=480]) DRR...
Hyperhomocysteinemia is an independent risk factor for atherothrombosis. However, causality unproven, and it remains unknown whether hyperhomocysteinemia promotes atherosclerosis, plaque rupture, and/or thrombosis. We evaluated the short- long-term effects of on size structure in 99 atherosclerosis-prone apolipoprotein E-deficient mice. was induced by methionine (Met) or homocysteine (HcyH) supplementation: low Met (+11 g Met/kg food), high (+33 HcyH (0.9 HcyH/L drinking water), (1.8 water)....
Background: Cerebral injury is an important complication after cardiac surgery with the use of cardiopulmonary bypass. The rate overt stroke 1% to 2%, whereas silent strokes, detected by diffusion-weighted magnetic resonance imaging, are found in up 50% patients. It unclear whether a higher versus lower blood pressure during bypass reduces cerebral infarction these Methods: In patient- and assessor-blinded randomized trial, we allocated patients (70–80 mm Hg) or (40–50 target for mean...
Objectives To describe the contemporary trends in use of mechanical circulatory support (MCS) patients with acute myocardial infarction and cardiogenic shock (AMICS). evaluate survival benefit early application intra-aortic balloon pump (IABP) or Impella CP. Methods A cohort study all consecutive AMICS undergoing percutaneous coronary intervention (PCI) <24 hours symptom onset (early PCI) southeastern Denmark from 2010 to 2017. matched case–control comparing 30-day mortality between...
Abstract Background Acute myocardial infarction complicated by cardiogenic shock (AMICS) is frequently preceded out-of-hospital cardiac arrest (OHCA), with risk of anoxic brain injury. Neuron-specific enolase (NSE) central to neuroprognostication; however, concomitant hemolysis can increase NSE independent neuronal injury due the presence in erythrocytes. This consideration critical AMICS patients treated a microaxial flow pump (Impella, Abiomed), where frequent. Methods and results We...
Cardiogenic shock (CS) is associated with high mortality and medical therapies have failed to improve survival. Treatment lactate improved cardiac function which may benefit this condition. Comprehensive hemodynamic assessment of administration in CS lacking, the mechanisms underlying cardiovascular effects not yet been elucidated. In study we aimed cardiometabolic treatment experimental ischemic CS. a randomized, blinded design, 20 female pigs (60 kg) were studied. Left main coronary artery...
Persistent pulmonary hypertension secondary to meconium aspiration syndrome is an important cause of morbidity and mortality in the neonatal population. We investigated use phosphodiesterase-5 inhibitor sildenafil, its intravenous form, as a vasodilator model syndrome. Pulmonary was induced 18 piglets, by endotracheal instillation human meconium, 6 piglets subsequently received infusion sildenafil for 2 hours, inhaled nitric oxide control animals no additional intervention. Meconium...
Right ventricular (RV) dilatation that occurs as a consequence of RV infarction is thought to produce hemodynamic instability by reducing left (LV) preload and compliance. We hypothesized these geometric changes may also adversely affect LV systolic performance.Twelve 40-kg pigs were studied. Integrated conductance catheters micromanometers placed in both the allow simultaneous recordings pressure volume derivation indices contractile function. ischemia was induced balloon occlusion proximal...
Background: The incidence of cardiogenic shock (CS) in patients with ST-segment elevation myocardial infarction (STEMI) is as high 10%. majority are thought to develop CS after admission (late CS), but the a contemporary STEMI cohort admitted for primary percutaneous intervention remains unknown. Aim: aim this study was assess and time onset suspected two high-volume tertiary heart centres variables associated development late CS. Methods: We included consecutive acute coronary angiography...
To date, data regarding the efficacy and safety of administering fibrinogen concentrate in cardiac surgery are limited. Studies limited by their low sample size large heterogeneity with regard to patient population, timing administration, definition transfusion trigger target levels. Assessment activity using viscoelastic point-of-care testing shortly before or after weaning from cardiopulmonary bypass patients procedures a high risk bleeding appears be rational strategy. In contrast, use...
Background There are few detailed descriptions of the inflammatory response to cardiac surgery with cardiopulmonary bypass (CPB) in children beyond 24 h postoperatively. This is especially true for antiinflammatory cytokines and extent tissue injury. The aim current study was describe injury responses uncomplicated pediatric CPB, where methylprednisolone modified ultrafiltration (MUF) were used. Methods Blood samples collected up 48 Cytokines (tumor necrosis factor-alpha interleukin-6,...
Background. Neutrophil Gelatinase-Associated Lipocalin (NGAL) has been described as an excellent marker of acute kidney injury (AKI) using the enzyme-linked immunosorbent assay (ELISA) from BioPorto Diagnostics, DK. Validation ELISA kit and investigation stability NGAL protein is a prerequisite before introducing for AKI in clinical research. Methods. Plasma urine samples healthy adult 16 children undergoing surgery congenital heart disease were used to validate 036 Diagnostics study...