A5042238081- Mechanical Circulatory Support Devices
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Cardiovascular and Diving-Related Complications
- Antimicrobial Resistance in Staphylococcus
- Thermal Regulation in Medicine
- Central Venous Catheters and Hemodialysis
- Orthopedic Infections and Treatments
- Cardiovascular Health and Disease Prevention
- MicroRNA in disease regulation
- Advanced MRI Techniques and Applications
- Cardiac Arrest and Resuscitation
- Inflammasome and immune disorders
- Sepsis Diagnosis and Treatment
- Cardiac Structural Anomalies and Repair
- Cardiac Ischemia and Reperfusion
- Cerebrovascular and Carotid Artery Diseases
- Fuel Cells and Related Materials
- Cardiovascular Function and Risk Factors
University of Freiburg
2016-2024
Universitäts-Herzzentrum Freiburg-Bad Krozingen
2021
University Medical Center Freiburg
2020
The novel coronavirus SARS-CoV-2 and the resulting disease COVID-19 causes pulmonary failure including severe courses requiring venovenous extracorporeal membrane oxygenation (V-V ECMO). Coagulopathy is a known complication of leading to thrombotic events embolism. It unclear if coagulopathy also increases circuit complications ECMO. Aim present study therefor was investigate rate V-V ECMO in COVID-19. We conducted retrospective registry all patients on treated at our centre between 01/2018...
Abstract Background Perioperative echocardiography is of paramount importance during cardiac surgery. Nonetheless, in the experimental large‐animal setting, it might be challenging obtaining optimal imaging when using conventional acquisition techniques, such as transthoracic and transesophageal screenings. Open‐chest surgery allows epicardial echocardiographic assessment with direct contact between probe heart, thus providing superior quality. Standard protocols regarding use ultrasound...
Whole body ischemia-reperfusion injury (IRI) after cardiopulmonary resuscitation (CPR) induces a generalized inflammatory response which contributes to the development of post-cardiac arrest syndrome (PCAS). Recently, pattern recognition receptors (PRRs), such as toll-like (TLRs) and inflammasomes, have been shown mediate in IRI. In this study we investigated monocyte PRR signaling function PCAS. Blood samples were drawn first 12 hours, at 24 48 hours following return spontaneous circulation...
Systemic inflammation is a major feature of the post-cardiac arrest syndrome. The three monocyte subpopulations are thought to play an important role in this inflammatory state because they endowed with numerous pattern recognition receptors, such as CD14, that have been associated ischemia-reperfusion injury. By contrast, exaggerated antiinflammatory response has also described following cardiac arrest, which may be mediated by downregulation antigen presentation receptor HLA-DR. We report...
MicroRNAs are key regulators of the cardiac response to injury. MiR-100 has recently been suggested be involved in different forms heart failure, but functional studies lacking. In present study, we examined impact transgenic miR-100 overexpression on structure and function during physiological aging pathological pressure-overload-induced failure mice after transverse aortic constriction surgery. was moderately upregulated induction pressure overload mice. While our model...
Abstract We comprehensively studied morphological and functional aortic aging in a population study using modern three-dimensional MR imaging to allow future comparison patients with diseases of the valve or aorta. followed 80 126 subjects (20 years age at baseline) identical methodology 6.0 ± 0.5 later. All underwent 3 T MRI thoracic aorta including 3D T1 weighted (spatial resolution 1 mm ) for measuring diameter plaque thickness 4D flow (spatial/temporal = 2 /20 ms) calculating global...
Indication of transesophageal echocardiography (TEE) in patients ≤60 years with brain ischemia is uncertain.This prospective double-blinded study included cryptogenic acute ischemic stroke or transient attack (TIA) ≥18 and years. After routine diagnostics, all underwent patent foramen ovale (PFO) screening by transcranial Doppler (TCD) bubble test, carotid ultrasound for atherosclerosis (intima-media-thickness >0.90 mm plaques), TEE. We calculated sensitivity, specificity, positive...