A5055194885- Cardiac Arrest and Resuscitation
- Thermal Regulation in Medicine
- Respiratory Support and Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Mechanical Circulatory Support Devices
- Intensive Care Unit Cognitive Disorders
- Trauma and Emergency Care Studies
- Sepsis Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Heart Rate Variability and Autonomic Control
- Cardiac, Anesthesia and Surgical Outcomes
- Veterinary Pharmacology and Anesthesia
- TGF-β signaling in diseases
- Ultrasound in Clinical Applications
- Restraint-Related Deaths
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Angiogenesis and VEGF in Cancer
- Medical and Health Sciences Research
- Aortic Disease and Treatment Approaches
- Nutrition and Health in Aging
- Heparin-Induced Thrombocytopenia and Thrombosis
- Apelin-related biomedical research
- Conducting polymers and applications
- Pediatric Pain Management Techniques
- IL-33, ST2, and ILC Pathways
University of Freiburg
2008-2024
University Medical Center Freiburg
2010-2023
Universitäts-Herzzentrum Freiburg-Bad Krozingen
2013
Fraunhofer Institute for Applied Polymer Research
2012
University of Cologne
2009
University Hospital of Zurich
2009
Grönemeyer Institute for MicroTherapy
2007
University of Tübingen
2007
University of Rochester
1945
Ischemia and reperfusion after cardiopulmonary resuscitation (CPR) induce endothelial activation systemic inflammatory response, resulting in post-resuscitation disease. In this study we analyzed direct markers of injury, circulating cells (CECs) microparticles (EMPs), progenitor (EPCs) as a marker repair patients CPR. First investigated injury 40 CPR, 30 controls with stable coronary artery disease (CAD), 9 healthy subjects, who were included to measure CECs EMPs. subsequent study, was...
Whole body ischemia-reperfusion injury (IRI) after cardiopulmonary resuscitation (CPR) induces a generalized inflammatory response which contributes to the development of post-cardiac arrest syndrome (PCAS). Recently, pattern recognition receptors (PRRs), such as toll-like (TLRs) and inflammasomes, have been shown mediate in IRI. In this study we investigated monocyte PRR signaling function PCAS. Blood samples were drawn first 12 hours, at 24 48 hours following return spontaneous circulation...
Microparticles are elevated in patients after successful cardiopulmonary resuscitation (CPR) and may play a role the development of endothelial dysfunction seen post-cardiac arrest syndrome (PCAS), life threatening disease with high mortality. To identify mechanisms activation to develop novel approaches therapy PCAS, impact selenium, trace element antioxidative properties, was characterized induced by microparticles resuscitated patients. Additionally, course plasma selenium levels first 72...
Abstract Background Typical lung ultrasound (LUS) findings in patients with a COVID-19 infection were reported early on. During the global SARS-CoV-2 pandemic, LUS was propagated as useful instrument triage and monitoring. We evaluated rapid diagnostic tool for management of suspected emergency department (ED). Methods The study retrospectively enrolled COVID-19, who admitted from 1st April to 25th 2020 ED tertiary care center Germany. clinical work-up, underwent polymerase chain reaction...
Pulse: 136 15 ml.blood taken Serum protein: 5.9 grams per cent Fibrinogen: 0.32 Hematocrit: 42.6 Specific gravity: 1.0227 Clotting time: 7 minutes and 35 seconds 1:20 P.M.-8 ml.Nembutal, intraperitoneally 1:45 P.M.-40 5.7 0.30 Whole blood NPN: 26.4 mgm.per 34.4 1.
The endothelial protein C-receptor (EPCR) is an transmembrane that binds C and activated (APC) with equal affinity, thereby facilitating APC formation. has anticoagulant, antiapoptotic antiinflammatory properties. Soluble EPCR, released by the endothelium, may bind neutrophils, modulating cell adhesion. EPCR therefore considered as a possible link between anticoagulant properties of inflammatory response neutrophils. In present study, we aimed to provide proof concept for direct binding...
Abstract Introduction Ischemia/reperfusion after cardiopulmonary resuscitation (CPR) induces systemic inflammatory response and activation of endothelium coagulation, resulting in a post-cardiac arrest syndrome. We analysed circulating (annexin V+) microparticles their conjugates resuscitated patients. Methods 36 patients successful resuscitation, 20 control with stable cardiac disease 15 healthy subjects were included prospectively. Two blood samples drawn, one immediately 24 hours return...
Systemic inflammation is a major feature of the post-cardiac arrest syndrome. The three monocyte subpopulations are thought to play an important role in this inflammatory state because they endowed with numerous pattern recognition receptors, such as CD14, that have been associated ischemia-reperfusion injury. By contrast, exaggerated antiinflammatory response has also described following cardiac arrest, which may be mediated by downregulation antigen presentation receptor HLA-DR. We report...
Background/Aims: Tissue hypoxia induces a variety of functional changes including enhanced transcriptional activity associated with high transmethylation (e.g. mRNA cap methylation) in the nucleus. It is well known that kidney responds to transcription erythropoietin (EPO) interstitial cells. Since S-adenosylhomocysteine (AdoHcy)-hydrolase regulates most S-adenosylmethionine (AdoMet) dependent reactions by hydrolyzing potent feedback inhibitor AdoHcy adenosine and homocysteine we studied...