A5003175746- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Trauma and Emergency Care Studies
- Ultrasound in Clinical Applications
- Mechanical Circulatory Support Devices
- Long-Term Effects of COVID-19
- Venous Thromboembolism Diagnosis and Management
- Thermal Regulation in Medicine
- Sepsis Diagnosis and Treatment
- Emergency and Acute Care Studies
- Disaster Response and Management
- COVID-19 Clinical Research Studies
- Airway Management and Intubation Techniques
- COVID-19 and healthcare impacts
- Respiratory and Cough-Related Research
- Cardiac Ischemia and Reperfusion
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Structural Anomalies and Repair
- Intracerebral and Subarachnoid Hemorrhage Research
- Palliative Care and End-of-Life Issues
- Intensive Care Unit Cognitive Disorders
- Restraint-Related Deaths
- Hemodynamic Monitoring and Therapy
- Healthcare Decision-Making and Restraints
- Neuroscience of respiration and sleep
University of Freiburg
2015-2023
University Medical Center Freiburg
2010-2022
Universitäts-Herzzentrum Freiburg-Bad Krozingen
2020-2021
Universidade Estadual de Campinas (UNICAMP)
2021
Marine nationale
2012
École Navale
2012
St. Pölten University of Applied Sciences
2011
University of Zurich
2011
Spitäler Schaffhausen
2003
Klinik und Poliklinik für Neurologie
1938
The role of the renin-angiotensin-aldosterone system (RAAS) in coronavirus disease 2019 (COVID-19) is controversially discussed. Severe acute respiratory syndrome 2 (SARS-CoV-2) enters host cells by binding to angiotensin-converting enzyme (ACE2) and activity RAAS may affect susceptibility SARS-CoV-2 infection outcome patients with COVID-19.In this prospective single-center study, we determined serum levels ACE2, angiotensin II, aldosterone COVID-19 compared control presenting similar...
Abstract Background A central element in the management of cardiogenic shock (CS) comprises mechanical circulatory support (MCS) systems to maintain cardiac output (CO). This study aims quantify incidence, outcome and influence MCS CS over last decade. Methods All patients hospitalized with a tertiary university hospital Germany between 2007 2017 were identified utilizing international coding system ICD-10 code R57.0. Application was via German procedure classification codes (OPS). Results...
Abstract Background ICU readmissions are associated with increased morbidity, mortality, and healthcare costs. As patient complexity increases care practices evolve, the contemporary epidemiology of remains unclear. We aimed to examine readmission rates timing across multiple health systems, focusing on unplanned occurring within 24, 48, 72 hours after discharge. Methods performed a retrospective cohort study using federated data from Common Longitudinal Format (CLIF) Consortium, comprising...
Abstract COVID-19 is associated with a variety of clinical complications including coagulopathy, which frequently results in venous thromboembolism (VTE). Retrospective analyses reported markedly increased rate VTEs COVID-19. However, most recent studies on coagulopathy were only focused critically ill patients, and without suitable control groups. We aimed to evaluate the an all-comers cohort suspected during 30-days follow-up period. also studied level D-dimers their association course...
Hypercoagulability in Coronavirus Disease 2019 (COVID-19) causes deep vein thrombosis and pulmonary embolism necessitating systemic anticoagulation. Case reports of intracerebral hemorrhages ventilated COVID-19 patients warrant precaution. It is unclear, however, if with acute respiratory distress syndrome (ARDS) or without veno-venous extracorporeal membrane oxygenation therapy (VV-ECMO) have more (ICH) compared to other ARDS patients.
Delirium is frequent in elderly patients presenting the emergency department (ED). Despite severe prognosis, majority of delirium cases remain undetected by physicians (EPs). At time our study there was no valid screening tool available for EDs German-speaking regions. We aimed to evaluate brief Confusion Assessment Method (bCAM) a German ED during daily work routine.We implemented bCAM into practice interdisciplinary high-volume and evaluated bCAM's validity convenience sample medical aged...
Microparticles are elevated in patients after successful cardiopulmonary resuscitation (CPR) and may play a role the development of endothelial dysfunction seen post-cardiac arrest syndrome (PCAS), life threatening disease with high mortality. To identify mechanisms activation to develop novel approaches therapy PCAS, impact selenium, trace element antioxidative properties, was characterized induced by microparticles resuscitated patients. Additionally, course plasma selenium levels first 72...
Abstract Background Typical lung ultrasound (LUS) findings in patients with a COVID-19 infection were reported early on. During the global SARS-CoV-2 pandemic, LUS was propagated as useful instrument triage and monitoring. We evaluated rapid diagnostic tool for management of suspected emergency department (ED). Methods The study retrospectively enrolled COVID-19, who admitted from 1st April to 25th 2020 ED tertiary care center Germany. clinical work-up, underwent polymerase chain reaction...
Severe courses of coronavirus disease 2019 (COVID-19) are associated with elevated levels interleukin 6 (IL-6). However, there is a growing body evidence pointing to broad and more complex disorder proinflammatory antiviral responses disturbed interferon signaling in COVID-19.In this prospective, single-center registry, we included severe acute respiratory syndrome 2 (SARS-CoV-2)-positive patients similar symptoms severity but negative for SARS-CoV-2 admitted the emergency department...
Abstract Subpleural consolidations have been found in lung ultrasound patients with COVID-19, possibly deriving from pulmonary embolism (PE). The diagnostic utility of impact critical-ill COVID-19 for PE diagnostics however is unclear. We retrospectively evaluated all SARS-CoV2-associated ARDS admitted to our ICU between March 8th and May 31th 2020. They were enrolled this study, when a computed tomography angiography (CTPA) documented. In addition, wells score was calculated estimate the...
Conflicting results have been reported on platelet activity ex vivo and responsiveness in vitro among patients with COVID-19 or without thromboembolic complications.To assess reactivity moderate disease at early stages of COVID-19.We performed a prospective, descriptive analysis 100 consecutive presenting suspected SARS-CoV-2 infection University Medical Center Freiburg during the first second wave pandemic. Following polymerase chain reaction testing compliance study inclusion criteria, 20...
Germany reported sufficient intensive care unit (ICU) resources throughout the first wave of coronavirus disease 2019 (COVID-19). The treatment critically ill COVID-19 patients without rationing may improve outcome. We therefore analyzed ICU allocated to with respiratory failure and their outcomes.
Abstract Background: Hypercoagulopathy in coronavirus disease 2019 (COVID-19) causing deep vein thrombosis and pulmonary artery embolism necessitate systemic anticoagulation. Case reports of intracerebral hemorrhages ventilated COVID-19 patients warrant precaution. It is unclear however, if with acute respiratory distress syndrome (ARDS) without extracorporeal membrane oxygenation therapy (ECMO) have more (ICH) compared to other ARDS patients. Methods: We conducted a retrospective...
Hemodynamic changes induced by self-contained underwater breathing apparatus diving were investigated using Doppler echocardiography. We detected circulating bubbles in both right and left cavities of the heart cerebral circulation two divers with a large patent foramen ovale. A reduction ventricular preload was suggested echocardiographic measurements. The decreased cardiac paralleled to lower stroke volume output. These findings also observed no evidence bubbles. In these subjects,...
Haemodynamic measurement plays an important role in the treatment of patients with acute heart failure and cardiogenic shock (CS). The pulmonary catheter (PAC) is a common device for enhanced haemodynamic measurement. aim this study was to evaluate comparability PiCCO PAC during CS; example, use intra-aortic counterpulsion (intraaortic balloon pumping (IABP)), therapeutic hypothermia after cardiac arrest.