A5022964111- COVID-19 Clinical Research Studies
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- SARS-CoV-2 detection and testing
- Antiplatelet Therapy and Cardiovascular Diseases
- COVID-19 and healthcare impacts
- Pulmonary Hypertension Research and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Inflammasome and immune disorders
- Diet and metabolism studies
- Sepsis Diagnosis and Treatment
- COVID-19 Impact on Reproduction
- Nitric Oxide and Endothelin Effects
- Adipokines, Inflammation, and Metabolic Diseases
- Treatment of Major Depression
- Complement system in diseases
- Neuropeptides and Animal Physiology
- Hormonal and reproductive studies
- Electroconvulsive Therapy Studies
- Thermal Regulation in Medicine
- Cardiac Arrest and Resuscitation
- Regulation of Appetite and Obesity
- Acute Myocardial Infarction Research
University of Freiburg
2019-2025
Universitäts-Herzzentrum Freiburg-Bad Krozingen
2019-2025
University Medical Center Freiburg
2020-2024
Krankenhaus der Augustinerinnen
2021
University of Cologne
2021
Cardiovascular Research Center
2021
Abstract COVID-19 is associated with a variety of clinical complications including coagulopathy, which frequently results in venous thromboembolism (VTE). Retrospective analyses reported markedly increased rate VTEs COVID-19. However, most recent studies on coagulopathy were only focused critically ill patients, and without suitable control groups. We aimed to evaluate the an all-comers cohort suspected during 30-days follow-up period. also studied level D-dimers their association course...
Coagulopathy and venous thromboembolism are common findings in coronavirus disease 2019 (COVID-19) associated with poor outcome. Timely initiation of anticoagulation after hospital admission was shown to be beneficial. In this study we aim examine the association pre-existing oral (OAC) outcome among a cohort SARS-CoV-2 infected patients.
Conflicting results have been reported on platelet activity ex vivo and responsiveness in vitro among patients with COVID-19 or without thromboembolic complications.To assess reactivity moderate disease at early stages of COVID-19.We performed a prospective, descriptive analysis 100 consecutive presenting suspected SARS-CoV-2 infection University Medical Center Freiburg during the first second wave pandemic. Following polymerase chain reaction testing compliance study inclusion criteria, 20...
Peripheral, non-neuronal serotonin promotes the recruitment of neutrophils to sites acute inflammation and tissue damage. Direct effects on neutrophil function were shown be involved. However, influence endothelial counterpart is unknown.To investigate whether alters cells in leukocyte during inflammation.We used two murine models inflammation: intraperitoneal lipopolysaccharide (LPS) injection mesenteric ischemia/reperfusion injury (I/R). To study peripheral serotonin, adhesion molecule...
Point-of-care (POC) polymerase chain reaction (PCR) tests have the ability to improve testing efficiency in Coronavirus disease 2019 (COVID-19) pandemic. However, real-world data on POC is scarce.To evaluate of a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test clinical setting and examine prognostic value cycle threshold (CT) admission length hospital stay (LOS) COVID-19 patients.Patients hospitalised between January May 2021 were included this prospective cohort...
The complement system (CS) plays a pivotal role in Coronavirus disease 2019 (COVID-19) pathophysiology. objective of this study was to provide comparative, prospective data analysis CS components an all-comers cohort and COVID-19 patients. Patients with suspected infection admitted the Emergency department were grouped for definite diagnosis no accordingly. Clinical presentation, routine laboratory von Willebrand factor (vWF) antigen as well 3, 4 activated 5 (C5a) assessed. Also, total...
Serotonin is involved in leukocyte recruitment during inflammation. Deficiency of the serotonin transporter (SERT) associated with metabolic changes humans and mice. A possible link interaction between inflammatory effects derangements SERT-deficient mice has not been investigated so far.SERT-deficient (Sert-/-) wild type (WT) were fed a high-fat diet, starting at 8 weeks age. Metabolic phenotyping (metabolic caging, glucose insulin tolerance testing, body organ weight measurements, qPCR,...
BackgroundAtrial fibrillation (AF) is common among patients in the intensive care unit (ICU) and can be triggered by severe illness or preexisting conditions. It debated if AF an independent predictor of poor outcome.MethodsData derives from a single center retrospective registry including all with stay on medical ICU for >24 h. The primary endpoint was survival. Secondary endpoints included receiving mechanical support (renal, respiratory circulatory), hemodynamic parameters during AF, rate...
Essentials•The impact of thromboprophylaxis on long-term outcomes in COVID-19 outpatients is unknown.•COVID-19 were randomized to receive vs no thromboprophylaxis.•There was difference hospitalization and death or functional status after 2 years.•Early does not improve outpatients.AbstractBackgroundEarly prevent hospital admissions among with symptomatic COVID-19. Its outcomes, including long COVID symptoms performance status, unknown.ObjectivesTo assess the effects given at time acute...
Abstract Background Various approaches exist for treatment of pulmonary embolism, including systemic lysis, catheter-directed therapy, or anticoagulation. Purpose This study aimed to describe recent secular trends strategies patients with embolism. Methods Data were interrogated from the Research Centre German Federal Statistical Office by ICD- and OPS-codes. 800,119 who treated in hospitals between 2007 2021, analyzed grouped according therapeutic strategy: no lysis intervention,...
Abstract High on-clopidogrel platelet reactivity (HPR) associates with ischemic risk in patients after percutaneous intervention (PCI). This study aimed to evaluate the association of HPR as assessed by multiple electrode aggregometry (MEA) ischemic, thromboembolic, and bleeding atrial fibrillation (AF) undergoing PCI. Patients AF an indication for oral anticoagulation (OAC) were included this prospective cohort on day 1–3 Platelet aggregation [U] was analyzed MEA. low (LPR) defined...
Background Post-cardiac arrest syndrome (PCAS) is a frequent complication following successful cardiopulmonary resuscitation and correlates with poor outcome. PCAS characterized by an excessive inflammatory response to whole-body ischemia reperfusion. Cytokine adsorption was suggested as adjunctive treatment option for the removal of cytokines from patients' blood restore physiological equilibrium pro- anti-inflammatory activity thus mitigate hemodynamic instability end-organ complications....
Objectives: Large amounts of peripheral serotonin are stored in dense granules circulating blood platelets. Serotonin is well known as a vasoactive mediator and platelet activator hemostasis. In the recent years it also became an immunomodulatory role inflammation by influencing recruitment leukocytes, especially neutrophils. Now, that we know, there kind immunothrombosis, its development arterial deep vein thrombosis needs to be investigated deeper.
Abstract Background Point-of-care (POC) polymerase chain reaction (PCR) tests have the ability to improve testing efficiency in Coronavirus disease 2019 (COVID-19) pandemic. However, real-world data on POC is scarce. Objective To evaluate of a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test clinical setting and examine prognostic value admission cycle threshold (CT) length hospital stay (LOS) COVID-19 patients. Methods Patients hospitalised between January May 2021...