Abstract Background A central element in the management of cardiogenic shock (CS) comprises mechanical circulatory support (MCS) systems to maintain cardiac output (CO). This study aims quantify incidence, outcome and influence MCS CS over last decade. Methods All patients hospitalized with a tertiary university hospital Germany between 2007 2017 were identified utilizing international coding system ICD-10 code R57.0. Application was via German procedure classification codes (OPS). Results...

Blood donation plays an important role in every health care system. Measurement of hemoglobin (Hb) concentration or hematocrit to assess hematologic recovery after may not adequately reflect the true amount blood as they are affected by plasma volume fluctuations. Instead, total Hb mass (tHb) is variable choice and can be determined routine clinical practice. Therefore, purpose was investigate tHb standard donation.The optimized CO rebreathing method used for evaluation before 1-unit...

BACKGROUND: Since no direct detection method for autologous blood transfusions exists, the most promising attempt is Athlete Biological Passport (ABP) and its adaptive model that enables a longitudinal monitoring of hematologic measures to identify patterns manipulations. The purpose therefore was evaluate performance this in blinded setting. STUDY DESIGN AND METHODS: Twenty‐one subjects were divided into doped group (multiple 1‐2 units red cells, n = 11) control (n 10). time course cycling...

MicroRNAs (miRNAs) are small non-coding RNAs that regulate various biological processes. Cell-free miRNAs measured in blood plasma have emerged as specific and sensitive markers of physiological processes disease. In this study, we investigated whether circulating can serve biomarkers for the detection autologous transfusion, a major doping technique is still undetectable. Plasma miRNA levels were analyzed using high-throughput quantitative real-time PCR. samples obtained before at several...

Haemoglobin (Hb) and haematocrit (Hct) are measured as indirect markers of doping in athletes. We studied the effect posture on these parameters a typical antidoping setting. Venous blood samples were obtained from nine endurance athletes (six males, three females) control subjects immediately after 5, 10, 15, 20 30 min having adopted seated position normal daily activity. Hb (CV 0.72%) Hct 0.87%) determined using an automated cell counter, plasma volume changes calculated. Differences...

Abstract The purpose of this study was to examine the distribution pace self-selected by cyclists varying ability, biological age and sex performing in a mountain bike World Championship event. Data were collected on Elite Male (ELITEmale; n = 75), Female (ELITEfemale; 50), Under 23 (U23male; 62), (U23female; 34), Junior (JNRmale; 71) (JNRfemale; 30) categories 2009 UCI Cross-Country Mountain Bike Championships. Split times recorded for top, middle bottom 20% all finishers each category....

Haemoglobin mass is a main determinant of maximal oxygen uptake. Blood doping aims at increasing this variable. Limits for haematocrit and haemoglobin concentration are used as indicators blood doping. However, these variables measures concentration, do not represent total altered by vascular volumes shifts. Direct estimation could improve tests. It unknown if physical exercise alters mass. The purpose study was to investigate the reaction other compartments heavy in athletes. were evaluated...

Purpose: An increase of hemoglobin (Hb) mass is the key target blood doping practices to enhance performance as it a main determinant maximal oxygen uptake. Although detection methods exist for with recombinant EPO and homologous transfusions, autologous transfusions remain virtually undetectable. In this context, most sensitive parameter would be determination Hb itself. The purpose therefore was establish whether measurements by optimized CO-rebreathing method allow screening withdrawal...

Introduction: With the setting up of newly Athlete's Biological Passport antidoping programme, novel guidelines have been introduced to guarantee results beyond reproach. We investigated in this context, effect storage time on variables commonly measured for haematological passport. also wanted assess these variables, within and between analyzer variations. Methods: Blood samples were obtained from top level male professional cyclists (27 first part study 102 second part) taking major stage...

Haemoglobin (Hb) and Reticulocytes (Ret) are measured as indirect markers of doping in athletes. We studied the diurnal variation, impact exercise, fluid intake ambient temperature athletes on these parameters. Hourly venous blood samples were obtained from 36 male different disciplines (endurance (END) non-endurance (NON-END)) over 12 h during a typical training day. Seven inactive subjects served controls (CON). Hb Ret determined. A mixed model procedure was used to analyse data. At...

In recent years, antidoping strategies underwent a significant development, from purely biochemical analyses and the detection of substances in urine samples to biological approach, using blood samples, longitudinal monitoring, probabilistic techniques. Nowadays, appropriate timing testing targeting athletes be tested with tests is major issue. A new strategy improve suspicious might monitoring individual performances. By these means, suspect identified, as doping will not only alter their...

The most promising attempt to reveal otherwise undetectable autologous blood doping is the Athlete Biological Passport enabling a longitudinal monitoring of hematological measures. Recently, determination hemoglobin mass (tHb) was suggested be incorporated in adaptive model Passport. purpose therefore evaluate performance tHb as part for detection transfusions blinded study.Twenty-one subjects were divided into doped group (n = 11) and control 10). During time course simulated cycling season...

In the context of interventional cardiology, platelet function testing may identify patients treated with P2Y12-inhibitors at an increased risk mortality, thrombosis and bleeding. Several whole blood point-of-care analyzers are available; however, inter-device differences have not been examined systematically. To compare three tests under standardized in vitro conditions. Healthy volunteer (n = 10) samples were spiked increasing concentrations ticagrelor (0-7500 ng/mL) and/or ASA (0-3280...

The aim of the study was to report relationship between cadence and power developed by professional cyclists during high mountain ascents Tour de France. From 10 (30 +/- 4 years, 178 8 cm, 69 6 kg) involved in study, 108 were recorded analyzed using a mobile measurement device (SRM Training Systems, Jülich, Germany). Based on topographic characteristics, categorized into 1st Hors Category (HC) climbs. During climbs, output averaged 312 43 W (4.5 0.6 W/kg) with mean 73 rpm duration 37 : 41 16...

Hemoglobin mass (tHb) is considered to be a main factor for sea-level performance after “live high–train low” (LHTL) altitude training, but little research has focused on the persistence of tHb following cessation exposure. The aim case study was investigate short-term effects various hematological measures including upon completion simulated camp. Five female cyclists spent 26 nights at (LHTL, 16.6 ± 0.4 h/d, 3000 m in an house) where measured baseline, camp, and 9 d thereafter. Venous...

Introduction: Determination of blood volume, red cell and plasma volume contributes to the understanding pathophysiology in heart failure, especially concerning anemia load. The optimized carbon monoxide (CO)-rebreathing method (oCORM) is used determine these parameters hemoglobin mass (Hbmass) exercise physiology. applicability oCORM intravascular volumes Hbmass failure patients currently undetermined because assumptions CO kinetics with rely on healthy subjects a normal ejection fraction....

Reticulocytes (Ret) are a key variable in the emerging concept of athlete's biological passport and longitudinal monitoring parameters field anti-doping. In this context, knowledge on variability Ret athletes influence exercise is necessary. The aim present study was to evaluate variation short- long-term exercise.Ret% 793 samples 238 were determined analyzed different parts for inter- intra-individual impact long- (competitive season) short-term (all out) exercise.Median Ret% 0.9...