A5060926879- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- COVID-19 Clinical Research Studies
- Cardiac Structural Anomalies and Repair
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- Heart Failure Treatment and Management
- Intensive Care Unit Cognitive Disorders
- Venous Thromboembolism Diagnosis and Management
- Sepsis Diagnosis and Treatment
- Disaster Response and Management
- SARS-CoV-2 and COVID-19 Research
- Anesthesia and Sedative Agents
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- Muscle and Compartmental Disorders
- Healthcare Decision-Making and Restraints
- Climate Change and Health Impacts
- COVID-19 and healthcare impacts
- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Nosocomial Infections in ICU
- Vascular Procedures and Complications
- Ultrasound in Clinical Applications
University of Freiburg
2017-2025
University Medical Center Freiburg
2009-2025
Ortenau Klinikum
2025
Heidelberg University
2020-2024
University Hospital Heidelberg
2020-2024
Universitäts-Herzzentrum Freiburg-Bad Krozingen
2016-2021
We sought to clarify the benefit of cytokine adsorption in patients with COVID-19 supported venovenous extracorporeal membrane oxygenation (ECMO).We did a single-centre, open-label, randomised, controlled trial investigate adult severe pneumonia requiring ECMO. Patients selected for ECMO at Freiburg University Medical Center (Freiburg, Germany) were randomly assigned (1:1) receive using CytoSorb device or not. Randomisation was computer-generated, allocation concealed by opaque, sequentially...
The COVID-19 pandemic strained health-care systems throughout the world. For some, available medical resources could not meet increased demand and rationing was ultimately required. Hospitals governments often sought to establish triage committees assist with allocation decisions. However, for institutions operating under crisis standards of care (during times when must be substantially lowered in setting crisis), relying on these decisions impractical-circumstances were changing too...
Prone positioning (PP) reduces mortality of patients with acute respiratory distress syndrome (ARDS). The potential benefit prone maneuvers during venovenous extracorporeal membrane oxygenation (ECMO) is unknown. aim this study was to evaluate the association between use support and ICU in a pooled population from previous European cohort studies.We performed individual patient data analysis studies which compared treated ECMO (Prone group) "conventional" management (Supine severe ARDS.889...
ABSTRACT Introduction Veno‐venous extracorporeal membrane oxygenation (V‐V ECMO) is increasingly used in the treatment of severe respiratory failure. Despite a significant increase worldwide use lung assist devices recirculation remains common complication and associated with reduced effectiveness ECMO support increased hemolysis. In this observational study we aimed to investigate impact cannula configuration flow on recirculation. Materials Methods An retrospective was performed, which...
The novel coronavirus severe acute respiratory syndrome 2 is infecting hundreds of thousands humans around the globe. disease 2019 (COVID-19) known to generate mild as well critical courses. Complications on intensive care units include distress syndrome, cardiac, and kidney injury shock. Here, we present first case report a successful treatment COVID-19 patient presenting with adult plus refractory combined cardiogenic vasoplegic shock, which could be successfully stabilized after...
individuals or clinicians will act on the test results, availability, and cost.Although trials of use rapid diagnostics are ideal to assess potential net effect all these variables important outcomes, doing such across wide range uses diagnostics, especially in context a global health emergency, is challenging.Modelling studies that incorporate parameters informed by realworld data from field can should inform investments being made development diagnostics.In future years, we probably...
The role of veno-venous extracorporeal membrane oxygenation therapy (V-V ECMO) in severe COVID-19 acute respiratory distress syndrome (ARDS) is still under debate and conclusive data from large cohorts are scarce. Furthermore, criteria for the selection patients that benefit most this highly invasive resource-demanding yet to be defined. In study, we assess survival an international multicenter cohort treated with V-V ECMO evaluate performance several clinical scores predict 30-day survival....
To investigate the efficacy of bilirubin reduction by hemoadsorption with CytoSorb® in patients acute-on-chronic liver failure (ACLF) receiving continuous renal replacement therapy (CRRT).
Abstract Background Venovenous extracorporeal membrane oxygenation (VV ECMO) is an established support option for patients with very severe respiratory failure and played important role during the coronavirus disease 2019 (COVID-19) pandemic. Bacteria fungi can lead to infectious complications in critically ill patients. The aim of this study was describe microbiological spectrum bacteria detected COVID-19-associated supported VV ECMO our center. Methods This retrospective single-center...
High-risk acute pulmonary embolism (PE) is a life-threatening condition necessitating hemodynamic stabilization and rapid restoration of perfusion. In this context, evidence regarding the benefit advanced circulatory support recanalization strategies still limited. observational study, we assessed data 1060 patients treated for high-risk PE with 991 being included in target trial emulation to investigate all-cause in-hospital mortality estimates different treatment strategies. The four...
Venovenous extracorporeal membrane oxygenation (VV-ECMO) provides gas exchange for patients with advanced respiratory failure who cannot maintain adequate or carbon dioxide (CO2) clearance through conventional mechanical ventilation. This review examines clinical applications of VV-ECMO a focus on optimizing oxygen delivery and CO2 removal. Over the past two decades, utilization has expanded, now serving as bridge to recovery in cases severe hypoxemic hypercapnic failure, procedural support,...
Introduction: Desirable outcome after venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome (ARDS) is frequently defined by survival. However, quality of life (QoL) and mental health status may take precedence over mere survival, from a patient-centered perspective. We aimed to evaluate QoL in survivors V-V ECMO coronavirus disease 2019 (COVID-19)-related ARDS, hypothesizing similar comparable the general population. Methods: All patients supported with...
Abstract COVID-19 is associated with a variety of clinical complications including coagulopathy, which frequently results in venous thromboembolism (VTE). Retrospective analyses reported markedly increased rate VTEs COVID-19. However, most recent studies on coagulopathy were only focused critically ill patients, and without suitable control groups. We aimed to evaluate the an all-comers cohort suspected during 30-days follow-up period. also studied level D-dimers their association course...
Veno-venous extracorporeal membrane oxygenation (V-V ECMO) is used to sustain blood and decarboxylation in severe acute respiratory distress syndrome (ARDS). It under debate if V-V ECMO as appropriate for coronavirus disease 2019 (Covid-19) ARDS it influenza. In this retrospective study, we analyzed all patients with confirmed SARS-CoV-2 or influenza A/B infection, ECMO, treated at our medical intensive care unit (ICU) between October 2010 June 2020. Baseline procedural characteristics well...
Veno-venous extracorporeal membrane oxygenation (V-V ECMO) is a last resort treatment option for patients with acute respiratory failure (acute distress syndrome [ARDS]). Cytokine adsorption has been incorporated in the management of some these on an individual basis to control imbalance danger-associated molecular patterns and proinflammatory cytokines. However, little known about combination V-V ECMO cytokine as earlier reports contained mixed patient cohorts terms disease mode ECMO,...
Extracorporeal life support (ECLS) is a means to patients with acute respiratory failure. Initially, recommendations treat severe cases of pandemic coronavirus disease 2019 (COVID-19) ECLS have been restrained. In the meantime, has shown produce similar outcomes in COVID-19 compared existing data on ARDS mortality. We performed an international email survey assess how providers worldwide previously used during treatment critically ill COVID-19. A questionnaire 45 questions (covering, e.g.,...
There is limited information about the long-term outcome of patients suffering from acute respiratory distress syndrome (ARDS) supported with veno-venous extracorporeal membrane oxygenation (VV ECMO). Most studies focused on short- to mid-term follow-up. We aimed investigate survival and health-related quality life (HRQL) in these patients.We report retrospective data a single-centre registry severe ARDS treated VV ECMO at Interdisciplinary Medical Intensive Care Unit Centre, University...