A5075537149- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- COVID-19 Clinical Research Studies
- Diet and metabolism studies
- Neuroendocrine Tumor Research Advances
- Heart Failure Treatment and Management
- Long-Term Effects of COVID-19
- Electron Spin Resonance Studies
- Cardiac Health and Mental Health
- Regulation of Appetite and Obesity
- Metastasis and carcinoma case studies
- Sepsis Diagnosis and Treatment
- Dietary Effects on Health
- Respiratory Support and Mechanisms
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
University of Freiburg
2019-2023
University Medical Center Freiburg
2020-2023
We sought to clarify the benefit of cytokine adsorption in patients with COVID-19 supported venovenous extracorporeal membrane oxygenation (ECMO).We did a single-centre, open-label, randomised, controlled trial investigate adult severe pneumonia requiring ECMO. Patients selected for ECMO at Freiburg University Medical Center (Freiburg, Germany) were randomly assigned (1:1) receive using CytoSorb device or not. Randomisation was computer-generated, allocation concealed by opaque, sequentially...
Veno-venous extracorporeal membrane oxygenation (V-V ECMO) is a last resort treatment option for patients with acute respiratory failure (acute distress syndrome [ARDS]). Cytokine adsorption has been incorporated in the management of some these on an individual basis to control imbalance danger-associated molecular patterns and proinflammatory cytokines. However, little known about combination V-V ECMO cytokine as earlier reports contained mixed patient cohorts terms disease mode ECMO,...
Even after the introduction of extracorporeal cardiopulmonary resuscitation (ECPR), survival cardiac arrest remains poor. Excess release vasoactive cytokines may be a reason for cardiovascular instability and death ECPR. Recently, an cytokine adsorption device (CytoSorb) to reduce elevated levels circulating has been introduced. So far, it unclear if this improve stabilization We report data from our investigator-initiated, single-center ECPR registry. compared 23 patients treated with...
Serotonin is involved in leukocyte recruitment during inflammation. Deficiency of the serotonin transporter (SERT) associated with metabolic changes humans and mice. A possible link interaction between inflammatory effects derangements SERT-deficient mice has not been investigated so far.SERT-deficient (Sert-/-) wild type (WT) were fed a high-fat diet, starting at 8 weeks age. Metabolic phenotyping (metabolic caging, glucose insulin tolerance testing, body organ weight measurements, qPCR,...
Background Post-cardiac arrest syndrome (PCAS) is a frequent complication following successful cardiopulmonary resuscitation and correlates with poor outcome. PCAS characterized by an excessive inflammatory response to whole-body ischemia reperfusion. Cytokine adsorption was suggested as adjunctive treatment option for the removal of cytokines from patients' blood restore physiological equilibrium pro- anti-inflammatory activity thus mitigate hemodynamic instability end-organ complications....