A5088344747- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Acute Myocardial Infarction Research
- Medical Practices and Rehabilitation
- Streptococcal Infections and Treatments
- Innovations in Medical Education
- Cardiovascular Effects of Exercise
- Immune Response and Inflammation
- Cerebrovascular and Carotid Artery Diseases
- Atherosclerosis and Cardiovascular Diseases
- Mechanical Circulatory Support Devices
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Issues in Pregnancy
- Cardiac Arrest and Resuscitation
- Coronary Interventions and Diagnostics
- Lipoproteins and Cardiovascular Health
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Heart Failure Treatment and Management
- Healthcare cost, quality, practices
- Pharmaceutical industry and healthcare
University Hospital Bonn
2022-2025
Die kardiologische Weiterbildung steht vor Herausforderungen wie der Verschiebung von stationären zu ambulanten Behandlungen, Digitalisierung mit möglicherweise Abnahme Untersuchungszahlen und begrenzter Diagnostikverfügbarkeit. Konflikte zwischen breiter internistischer Ausbildung früher Spezialisierung sowie fehlende flexible Arbeitszeitmodelle Integrationsprogramme für ausländische Fachkräfte erschweren die Ausbildungsorganisation Vereinbarkeit Familie Beruf. Um Attraktivität Kardiologie...
High-risk acute pulmonary embolism (PE) is a life-threatening condition necessitating hemodynamic stabilization and rapid restoration of perfusion. In this context, evidence regarding the benefit advanced circulatory support recanalization strategies still limited. observational study, we assessed data 1060 patients treated for high-risk PE with 991 being included in target trial emulation to investigate all-cause in-hospital mortality estimates different treatment strategies. The four...
Soziale Medien in der Kardiologie bieten sowohl Chancen als auch Gefahren. Sie ermöglichen einerseits eine schnelle Verbreitung von wissenschaftlichen Erkenntnissen, die Vernetzung Fachleuten und Plattform für den interaktiven Austausch. Andererseits fehlen bislang klare Qualitätskriterien Inhalte. Ebenso gestaltet sich Überprüfung Autoren deren Informationen schwierig. Für einen rechtskonformen Gebrauch sozialer sollten vor einer Nutzung damit einhergehenden juristischen Fallstricke bekannt...
Aortic valve stenosis (AS) development is driven by distinct molecular and cellular mechanisms which include inflammatory pathways. Toll-like-receptor-3 (TLR3) a lysosomal pattern-recognition receptor that binds double-stranded RNA promotes pro-inflammatory responses. In recent years, TLR3 has emerged as major regulator of vascular inflammation. The exact role in the AS not been investigated. Isolated human valvular interstitial cells (VICs) were stimulated with TLR3-agonist polyIC resulting...
Lactate and glucose are widely used biochemical parameters in current predictive risk scores for cardiogenic shock. Data regarding the relationship between lactate levels shock limited. Thus, we aimed to analyze as early markers in-hospital mortality In this retrospective cohort study, 312 patients presenting with a tertiary-care hospital 2016 2018 were included. Apparent was defined hypoperfusion hemodynamic compromise marker increase due diminished tissue perfusion, corresponding SCAI...
Abstract Background Delayed coronary obstruction (DCO) is a rare but potentially life-threatening complication after transcatheter aortic valve implantation (TAVI) mostly affecting the left main artery (LMCA) and often caused by prosthesis endothelialization or thrombus formations. Herein, we report an unusual case of delayed LMCA-obstruction calcium nodule, which was diagnosed 4 months TAVI due to recurrent ventricular tachycardia (VT) episodes. Case summary A 73-year-old patient readmitted...
Abstract Background Stent under-expansion, often caused by severe circumferential coronary calcification, must be prevented as it increases the risk of neoatherosclerosis and stent thrombosis. Intravascular lithotripsy (IVL) is an effective lesion preparation strategy to enable sufficient expansion a that was initially not sufficiently expanded. Case summary A 62-year-old male patient presented in our emergency department due unstable angina. Coronary angiography revealed one-vessel artery...
Abstract Background The ESC guidelines underscore the importance of objective risk stratification in making patient-centered decision for valve interventions. However, they primarily rely on surgical scores, not considering essential factors such as frailty. Computed tomography (CT) is a routine part pre-interventional workup patients undergoing TAVR and allows body composition analysis, including assessment fat-free muscle fraction (FFMF) an indicator quality. Purpose This study aimed to...
Zusammenfassung Die kalzifizierende Aortenklappenstenose stellt die häufigste interventionell oder operativ behandlungsbedürftige Herzklappenerkrankung im Erwachsenenalter dar und betrifft insbesondere Menschen höheren Lebensalters. Obwohl der Fortschritt interventioneller Therapieoptionen Behandlung in den letzten Jahren verbessern konnte, ist symptomatische weiterhin mit hoher Morbidität Letalität assoziiert. Ihre Pathophysiologie gekennzeichnet durch eine Fibrosierung Kalzifizierung...
Abstract Background Aortic valve stenosis (AVS) is the most prevalent heart disease worldwide and mainly affects elderly. In observational clinical studies, postmenopausal osteoporosis, which 30 % of all women, associated with increased aortic calcification stenosis. However, there are no pathomechanistic investigations that link these diseases. this study, we analyzed impact osteoporosis in ovariectomized C57BL6/J mice on occurrence progression wire injury-induced Methods To induce...
Abstract Background Calcific aortic valve stenosis (CAVD) is the most prevalent heart disease worldwide and, in advanced stages, leads to clinical deterioration and poor prognosis. Until now, no medical treatment available. Thought be a merely degenerative disease, we now know that initiation progression are actively regulated by immune cell infiltration, chronic inflammation, osteogenic differentiation of valvular interstitial cells (VIC) endothelial-to-mesenchymal transition (EndMT)...