A5036440219- Mechanical Circulatory Support Devices
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Cardiac Arrest and Resuscitation
- Long-Term Effects of COVID-19
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Metabolism and Genetic Disorders
- Pulmonary Hypertension Research and Treatments
- SARS-CoV-2 and COVID-19 Research
- Tracheal and airway disorders
- Intensive Care Unit Cognitive Disorders
- Lipoproteins and Cardiovascular Health
- Cardiac Structural Anomalies and Repair
- Neonatal Respiratory Health Research
- Pediatric health and respiratory diseases
- Pneumonia and Respiratory Infections
- Transplantation: Methods and Outcomes
- Liver Disease Diagnosis and Treatment
- Sepsis Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- Parathyroid Disorders and Treatments
- Diabetes Management and Research
- Nosocomial Infections in ICU
- Heart Failure Treatment and Management
- Respiratory viral infections research
Saarland University
2016-2025
Universitätsklinikum des Saarlandes
2014-2025
Institute for Sports Medicine
2024
World Health Organization - Pakistan
2024
University Medical Center
2016-2024
Zimmer Biomet (Netherlands)
2024
Integrated Oncology (United States)
2024
Infectious Diseases Institute
2020
Institute of Medical Microbiology and Hygiene
2020
University Hospital and Clinics
2016-2017
High-density lipoproteins (HDLs) are considered as anti-atherogenic. Recent experimental findings suggest that their biological properties can be modified in certain clinical conditions by accumulation of serum amyloid A (SAA). The effect SAA on the association between HDL-cholesterol (HDL-C) and cardiovascular outcome remains unknown.We examined HDL-C with mortality Ludwigshafen Risk Cardiovascular Health (LURIC) study, which included 3310 patients undergoing coronary angiography. To...
<b>Objective</b> To examine whether acute dysglycaemia predicts death in people admitted to hospital with community acquired pneumonia. <b>Design</b> Multicentre prospective cohort study. <b>Setting</b> Hospitals and private practices Germany, Switzerland, Austria. <b>Participants</b> 6891 patients pneumonia included the German competence network (CAPNETZ) study between 2003 2009. <b>Main outcome measures</b> Univariable multivariable hazard ratios adjusted for sex, age, current smoking...
BACKGROUND. Patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) differ in the severity of disease. We hypothesized that characteristics SARS-CoV-2–specific immunity correlate disease severity.
Rationale: Patients with interstitial lung disease and acute respiratory failure have a poor prognosis especially if mechanical ventilation is required.Objectives: To investigate the outcome of patients in undergoing extracorporeal membrane oxygenation (ECMO) as bridge to recovery or transplantation.Methods: This was retrospective analysis all treated without ECMO from March 2012 August 2015.Measurements Main Results: Forty referred our intensive care unit for were included analysis....
In the general population, HDL cholesterol (HDL-C) is associated with reduced cardiovascular events. However, recent experimental data suggest that vascular effects of can be heterogeneous. We examined association HDL-C all-cause and mortality in Ludwigshafen Risk Cardiovascular Health study comprising 3307 patients undergoing coronary angiography. Patients were followed for a median 9.9 years. Estimated GFR (eGFR) was calculated using Chronic Kidney Disease Epidemiology Collaboration eGFR...
The vascular effects of high-density lipoproteins (HDL) differ under certain clinical conditions. composition HDL is modified in patients with chronic kidney disease (CKD). As a consequence, uremic induces endothelial dysfunction. We have previously shown that accumulation symmetric dimethylarginine (SDMA) causes these adverse CKD. aim the study to determine impact SDMA on association between and mortality.Mortality, renal function, serum HDL-cholesterol (HDL-C) were assessed LURIC including...
BACKGROUNDCOVID-19 convalescent plasma (CCP) has been considered a treatment option for COVID-19. This trial assessed the efficacy of neutralizing antibody containing high-dose CCP in hospitalized adults with COVID-19 requiring respiratory support or intensive care treatment.METHODSPatients (n = 105) were randomized 1:1 to either receive standard and 3 units alone. Control group patients progress on day 14 could cross over group. The primary outcome was dichotomous composite survival no...
Against the background of pandemic caused by infection with SARS-CoV-2 virus, German Respiratory Society has appointed experts to develop therapy strategies for COVID-19 patients acute respiratory failure (ARF). Here we present key position statements including observations about pathophysiology In terms pulmonary SARS-CoV-2, can be divided into 3 phases. Pulmonary damage in advanced often differs from known changes distress syndrome (ARDS). Two types (type L and type H) are differentiated,...
Abstract Background Effective antimicrobial treatment is key to reduce mortality associated with bacterial sepsis in patients on intensive care units (ICUs). Dose adjustments are often necessary account for pathophysiological changes or renal replacement therapy. Extracorporeal membrane oxygenation (ECMO) increasingly being used the of respiratory and/or cardiac failure. However, it remains unclear whether dose avoid subtherapeutic drug levels septic ECMO support. Here, we aimed evaluate and...
As a consequence of the continued Covid-19 lockdown in Germany, in-hospital teaching for medical students was impossible. While lectures and other theoretical training were relatively easily converted into online sessions using platforms such as Moodle, Zoom Microsoft Teams, this not case practical skills clinical interventions, bronchoscopy or colonoscopy. This study describes workaround that implemented at Saarland University Hospital utilizing virtual reality equipment to convey...
Abstract Introduction Several recent studies have shown that a positive fluid balance in critical illness is associated with worse outcome. We tested the effects of moderate vs. high-volume resuscitation strategies on mortality, systemic and regional blood flows, mitochondrial respiration, organ function two experimental sepsis models. Methods 48 pigs were randomized to continuous endotoxin infusion, fecal peritonitis, control group (n = 16 each), each further different basal rates volume...
Alpha1-antitrypsin (AAT) deficiency, although largely under-diagnosed, is the underlying cause of approximately 1% COPD cases. Lack awareness leads to long delays in diagnostic testing. Subsequently, lifestyle and treatment choices with potentially positive effects on prognosis may be postponed.Data testing practices for AAT deficiency were derived from University Pavia, Italy, Marburg, Germany. In addition, a survey physicians was undertaken explore their attitudes toward deficiency.In...
Abstract Bacterial pathogens are a leading cause of lung infections and contribute to acute exacerbations in patients with chronic respiratory diseases. The innate immune system the tract controls prevents colonization bacterial pathogens. Forkhead box transcription factor family O (FOXO) factors key regulators cellular metabolism, proliferation, stress resistance. In this study, our aim was investigate role FOXO functions epithelial cells. We show that potently activate cultured human cells...
Background Changes in pulmonary hemodynamics and ventilation/perfusion were proposed as hallmarks of Coronavirus disease 2019 (COVID‐19)–induced acute respiratory distress syndrome (ARDS). Inhaled nitric oxide (iNO) may overcome these issues improve arterial oxygenation. Methods We retrospectively analyzed oxygenation vasoreactivity seven COVID‐19 ARDS patients receiving 20 ppm iNO for 15‐30 minutes. Results The inhalation NO significantly improved All with severe had higher partial...
Even though bleeding and thromboembolic events are major complications of extracorporeal membrane oxygenation (ECMO), data on the incidence venous thrombosis (VT) thromboembolism (VTE) under ECMO scarce. This study analyzes predictors VTE in patients treated with due to respiratory failure.Retrospective analysis our center from 04/2010 11/2015. Patients prior admission were excluded. Diagnosis was made by imaging survivors postmortem examination deceased patients.Out 102 screened cases, 42...
Against the background of pandemic caused by infection with SARS-CoV-2, German Society for Pneumology and Respiratory Medicine (DGP e.V.), in cooperation other associations, has designated a team experts order to answer currently pressing questions about therapy strategies dealing COVID-19 patients suffering from acute respiratory insufficiency (ARI).The position paper is based on current knowledge that evolving daily. Many published cited studies require further review, also because many...
Severe COVID-19 induced acute respiratory distress syndrome (ARDS) often requires extracorporeal membrane oxygenation (ECMO). Recent German health insurance data revealed low ICU survival rates. Patient characteristics and experience of the ECMO center may determine intensive care unit (ICU) survival. The current study aimed to identify factors affecting patients.673 ARDS patients treated in 26 centers between January 1st 2020 March 22nd 2021 were included. Data on clinical characteristics,...