A5059480753- Neuroblastoma Research and Treatments
- Neonatal Respiratory Health Research
- Amyotrophic Lateral Sclerosis Research
- Pancreatic and Hepatic Oncology Research
- Intensive Care Unit Cognitive Disorders
- SARS-CoV-2 and COVID-19 Research
- Biomedical and Engineering Education
- Neurogenetic and Muscular Disorders Research
- COVID-19 Clinical Research Studies
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Mobile Health and mHealth Applications
- Cancer, Hypoxia, and Metabolism
- Parkinson's Disease Mechanisms and Treatments
- Prostate Cancer Treatment and Research
- Cholinesterase and Neurodegenerative Diseases
- Statistical Methods in Clinical Trials
- Pain Management and Opioid Use
- Animal testing and alternatives
- Gastric Cancer Management and Outcomes
- Prostate Cancer Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Long-Term Effects of COVID-19
- Neonatal and fetal brain pathology
- Respiratory Support and Mechanisms
Zimmer Biomet (Germany)
2016-2025
Universität Ulm
2016-2025
Helmholtz-Institute Ulm
2025
Institut für Medizinische Biometrie, Informatik und Epidemiologie
2014-2024
University Hospital Heidelberg
2024
Heidelberg University
2019-2024
Marienhospital Stuttgart
2023
Stuttgart Observatory
2023
Klinikum Ludwigsburg
2023
German Center for Neurodegenerative Diseases
2023
Objective To determine the diagnostic and prognostic performance of serum neurofilament light chain (NFL) in amyotrophic lateral sclerosis (ALS). Methods This single-centre, prospective, longitudinal study included following patients: 124 patients with ALS; 50 without neurodegenerative diseases; 44 conditions differential diagnosis ALS (disease controls); 65 other diseases (20 frontotemporal dementia, 20 Alzheimer’s disease, 19 Parkinson’s 6 Creutzfeldt-Jakob disease (CJD)). Serum NFL levels...
To examine neurofilament (Nf) concentrations according to symptom onset and clinical diagnostic certainty categories of amyotrophic lateral sclerosis (ALS).We measured Nf light chain (NfL) phosphorylated heavy (pNfH) CSF NfL serum levels in patients with ALS first ≤6 months (n = 54) or >6 135) from sampling, other neurologic diseases, differential diagnoses a motor neuron disease (MND mimics), MND variants determine the accuracy early onset. Samples were received multicentric analyzed by...
BackgroundHeterologous COVID-19 vaccination regimens combining vector- and mRNA-based vaccines are already administered, but data on solicited adverse reactions, immunological responses elicited protection limited.MethodsTo evaluate the reactogenicity humoral as well cellular immune towards most prevalent SARS-CoV-2 variants after a heterologous ChAdOx1 nCoV-19 BNT162b2 prime-boost vaccination, we analysed cohort of 26 clinic employees aged 25-46 (median 30.5) years who received prime...
SARS-CoV-2 is a respiratory pathogen and primarily infects the airway epithelium. As our knowledge about innate immune factors of tract against limited, we generated screened peptide/protein library derived from bronchoalveolar lavage for inhibitors spike-driven entry. Analysis antiviral fractions revealed presence α1-antitrypsin (α1AT), highly abundant circulating serine protease inhibitor. Here, report that α1AT inhibits entry at physiological concentrations suppresses viral replication in...
<h3>Objective</h3> To determine the association of serum neurofilament light chain (NfL) with functional deterioration and brain atrophy during follow-up patients behavioral variant frontotemporal dementia (bvFTD). <h3>Methods</h3> Blood NfL levels from 74 bvFTD, 26 Alzheimer disease (AD), 17 mild cognitive impairment (MCI), 15 healthy controls (Con) at baseline were determined analyzed for diagnostic potential in relation to assessment (Clinical Dementia Rating Scale Sum Boxes [CDR-SOB],...
Polytrauma (PT) is frequently associated with hemorrhagic shock (HS), which increases morbidity and mortality. Although various aspects of HS have been addressed in PT patients, the impact an additional largely unknown regarding development multiple organ dysfunction disturbed glycocalyx barrier function early after trauma. A prospective, longitudinal, mono-centered, observational study enrolling severely injured patients (Injury Severity Score, ISS = 38.1 ± 2.6) served for in-depth analysis...
BACKGROUNDCOVID-19 convalescent plasma (CCP) has been considered a treatment option for COVID-19. This trial assessed the efficacy of neutralizing antibody containing high-dose CCP in hospitalized adults with COVID-19 requiring respiratory support or intensive care treatment.METHODSPatients (n = 105) were randomized 1:1 to either receive standard and 3 units alone. Control group patients progress on day 14 could cross over group. The primary outcome was dichotomous composite survival no...
Elevated levels of neurofilament light (NfL) and heavy (NfH) chain in amyotrophic lateral sclerosis (ALS) cerebrospinal fluid (CSF) serum reflect neuro-axonal degeneration are used as diagnostic biomarkers. However, studies comparing the differential potential for ALS all four parameters missing. Here, we measured NfL/NfH CSF a large cohort other neurological disorders analysed potential.In total 294 patients were analysed. The groups comprised: (n=75), frontotemporal lobar (FTLD) (n=33),...
Abstract INTRODUCTION β‐synuclein is a promising blood marker to track synaptic degeneration in Alzheimer's disease (AD) but changes preclinical AD are unclear. METHODS We investigated serum 69 cognitively unimpaired mutation non‐carriers, 78 carriers (asymptomatic AD), and 31 symptomatic from the Dominantly Inherited Alzheimer Network. RESULTS levels were already higher asymptomatic compared non‐carriers highest carriers. Longitudinal trajectories correlation analyses indicated that start...
Abstract Knowledge about the nature of pathomolecular alterations preceding onset symptoms in amyotrophic lateral sclerosis is largely lacking. It could not only pave way for discovery valuable therapeutic targets but might also govern future concepts pre-manifest disease modifying treatments. MicroRNAs are central regulators transcriptome plasticity and participate pathogenic cascades and/or mirror cellular adaptation to insults. We obtained comprehensive expression profiles microRNAs serum...
There is a need for diagnostic, prognostic, and monitoring blood biomarkers ALS. We aimed to analyse compare proposed candidate markers disease progression in the course of Blood samples were taken from 125 ALS patients, including nine patients with C9orf72 or SOD1 mutation, at regular intervals six months. characterized by functional rating scale (ALSFRS-R) Edinburgh Cognitive Behavioural Screen (ECAS). quantified neurofilament light chain (NF-L), S100B, progranulin (PGRN) analysed it...
In recent years it has been controversially discussed in the literature if smoking is associated with activity of cutaneous lupus erythematosus (CLE) and efficacy antimalarial agents.To investigate influence on disease severity treatment patients CLE using Core Set Questionnaire European Society Cutaneous Lupus Erythematosus (EUSCLE).A total 1002 (768 female, 234 male) different subtypes were included this cross-sectional study, which was performed 14 countries. Smoking behaviour assessed by...