A5078473756- Pelvic and Acetabular Injuries
- Spinal Fractures and Fixation Techniques
- Trauma and Emergency Care Studies
- Immune Response and Inflammation
- Spine and Intervertebral Disc Pathology
- Organ Transplantation Techniques and Outcomes
- Trauma Management and Diagnosis
- Radiation Dose and Imaging
- Pregnancy-related medical research
- Abdominal Trauma and Injuries
- Shoulder and Clavicle Injuries
- Sepsis Diagnosis and Treatment
- Shoulder Injury and Treatment
- Bone fractures and treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Hernia repair and management
- Advanced X-ray and CT Imaging
- Erythropoietin and Anemia Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood transfusion and management
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Cardiac Arrest and Resuscitation
- Heparin-Induced Thrombocytopenia and Thrombosis
- Respiratory Support and Mechanisms
University Hospital of Zurich
2009-2023
University of Zurich
2008-2023
Krankenhaus Bethanien
2023
Schwarzwald-Baar Klinikum
2017-2023
University of Freiburg
2017-2020
University Clinic of Traumatology
2013
MetroHealth
2012
MetroHealth Medical Center
2012
Institute of Social and Preventive Medicine
2012
Orthopaedic Trauma Association
2011
SCCM Pediatric Critical Care Medicine Explorations
ABSTRACT—To study the role of Kupffer cells (KC) as a cellular source proinflammatory cytokines in hepatic ischemia/reperfusion, Sprague-Dawley rats were subjected to 20 min global ischemia. Sham-operated animals served controls. Blood levels tumor necrosis factor-α (TNF-α), interleukin-1α (IL-α), and interleukin 6 (IL-6) determined after 10, 30, 60, 120, 240 reperfusion compared with spontaneous cytokine release by KC isolated 60 reperfusion. Hepatic ischemia/ resulted an enhanced (p < .01)...
We investigated whether hyperfibrinolysis and its severity was associated with outcome of traumatized nontraumatized patients.From April 2008 to 2010, all emergency patients were enrolled in this study. Hyperfibrinolysis divided into (trauma group) (nontrauma group). The trauma group matched 24 polytrauma without (matched Data from rotational thromboelastometry measurements, blood gas analysis (metabolic state), laboratory analysis, injury score, 30-day mortality collected.Thirty-five...
BACKGROUND Patient blood management (PBM) measures have been shown to be effective in reducing transfusions while maintaining patient outcome. The issuance of transfusion guidelines is seen as being key the success PBM programs. As introduction alone did not visibly reduce our center, a monitoring and feedback program was established. aim study show effectiveness such cost. STUDY DESIGN AND METHODS We designed prospective, interventional cohort with 3‐year time frame (January 1, 2012...
To assess the value of iterative frequency split-normalized (IFS) metal artifact reduction (MAR) for computed tomography (CT) hip prostheses.This study had institutional review board and local ethics committee approval. First, a phantom with steel titanium prostheses that inlays water, fat, contrast media in pelvis was used to optimize IFS algorithm. Second, 41 consecutive patients who were undergoing CT included. Data sets reconstructed filtered back projection, algorithm, linear...
Purpose To evaluate prospectively the performance of noncalcium images reconstructed from dual-energy (DE) computed tomography (CT) for diagnosis bone marrow lesions in patients with acute ankle joint trauma comparison magnetic resonance (MR) images. Materials and Methods The study had local ethics board approval, written informed consent was obtained. Thirty consecutive (15 women; mean age, 34 years ± 11.8 [standard deviation]) underwent dual-source DE CT (80 kVp 140 tin filter) MR imaging...
Summary Trauma promotes trauma‐induced coagulopathy, which requires urgent treatment with fixed‐ratio transfusions of red blood cells, fresh frozen plasma and platelet concentrates, or goal‐directed administration coagulation factors based on viscoelastic testing. This retrospective observational study compared two time periods before (2005–2007) after (2012–2014) the implementation changes in trauma management protocols included: use management; admission patients to designated centres;...
Polytrauma (PT) is frequently associated with hemorrhagic shock (HS), which increases morbidity and mortality. Although various aspects of HS have been addressed in PT patients, the impact an additional largely unknown regarding development multiple organ dysfunction disturbed glycocalyx barrier function early after trauma. A prospective, longitudinal, mono-centered, observational study enrolling severely injured patients (Injury Severity Score, ISS = 38.1 ± 2.6) served for in-depth analysis...
Heme oxygenase (HO) catalyzes the oxidative cleavage of α-mesocarbon Fe-protoporphyrin-IX yielding equimolar amounts biliverdin-IXa, iron, and carbon monoxide. The HO-system consists two isoenzymes, namely HO-2 inducible isoform HO-1, also referred to as heat shock protein (hsp) 32. Although both parenchymal non-parenchymal liver cells participate in heme metabolism, expression pattern isoenzymes normal stress exposed is unknown. To study this, rats underwent either endotoxin...
Background Operative treatment of displaced proximal humeral fractures often results in poor functional outcome. We report a technique that provides improved rotational stability the fracture and thus allows early treatment. Methods Seventy-one consecutive patients (67 ± 18 years) with humerus (two-part, n = 10; three-part, 41; four-part, 20) were treated by open reduction internal fixation using two one-third tubular plates on anterior lateral aspects humerus. Passive motion was started...
To determine the number of imaging examinations, radiation dose and time to complete trauma-related in multiple trauma patients before after introduction whole-body CT (WBCT) into early care.120 consecutive 120 WBCT algorithm University Hospital Zurich were compared regarding type CT, radiography, focused assessment with sonography for (FAST), additional examinations (defined as same body regions radiography and/or FAST) imaging.In cohort, significantly more underwent head, neck, chest...
Background Various anesthetics have been suggested to interfere with the immune system. The ability of leukocytes express surface receptors and mediators is fundamental a successful host defense. Therefore, effects intravenous on cytokine release by expression molecules known modulate this response were determined. Methods Concentration-dependent thiopentone, etomidate, propofol, ketamine, midazolam, fentanyl spontaneous endotoxin (lipopolysaccharide; 1 microg/ml)-stimulated studied in whole...
Gadolinium chloride (GdCI3) has been reported to block Kupffer cell (KC) phagocytic activity in rats. In this study, we investigated the action of GdCI3 on cells and related effects response lipopolysaccharide (LPS) exposure Using intravital fluorescence microscopy (IVFM), hepatic microcirculation (phagocytic zonal distribution KC, sinusoidal perfusion, leukocyte-endothelial interaction) rats pretreated with either saline or (10 mg/kg i.v. for 2 days) was studied at 1 h (n = 14) 16 16) after...
Abstract Background The prolonged administration of heparin for prevention and treatment venous thromboembolism has been associated with a risk heparin-induced osteoporosis. Fondaparinux is new antithrombotic drug that specifically inhibits factor Xa. Because the known interactions other agents bone remodelling, effects fondaparinux on human osteoblasts were analysed in vitro. Methods Primary osteoblast cell cultures incubated either low molecular weight dalteparin at concentrations 30, 300...
Pathogen-pattern-recognition by Toll-like receptors (TLRs) and pathogen clearance after immune complex formation via engagement with Fc (FcRs) represent central mechanisms that trigger the inflammatory responses. In present study, a linkage between TLR4 FcγR was evaluated in vitro vivo. Most strikingly, activation of phagocytes IgG complexes (IgGIC) resulted an association FcγRIII (CD16) based on co-immunoprecipitation analyses. Neutrophils macrophages from mutant (mut) mice were...