A5001601302- Lymphatic System and Diseases
- Reconstructive Surgery and Microvascular Techniques
- Wound Healing and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Lymphatic Disorders and Treatments
- Vascular Malformations and Hemangiomas
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Diagnosis and Treatment of Venous Diseases
- Reconstructive Facial Surgery Techniques
- Angiogenesis and VEGF in Cancer
- Breast Implant and Reconstruction
- Venous Thromboembolism Diagnosis and Management
- Orthopedic Surgery and Rehabilitation
- Erythropoietin and Anemia Treatment
- 3D Printing in Biomedical Research
- Nerve Injury and Rehabilitation
- Body Contouring and Surgery
- Macrophage Migration Inhibitory Factor
- Systemic Sclerosis and Related Diseases
- Thermal Regulation in Medicine
- Cutaneous Melanoma Detection and Management
- Sepsis Diagnosis and Treatment
- Burn Injury Management and Outcomes
- Breast Cancer Treatment Studies
University Hospital of Zurich
2016-2025
University of Zurich
2008-2024
Linden Photonics (United States)
2024
Center For Reconstructive Urethral Surgery
2019
Rostocker Zentrum zur Erforschung des Demografischen Wandels
2018
Cerbomed (Germany)
2018
Swiss Integrative Center for Human Health
2016-2017
Zero to Three
2016
Engineering and Physical Sciences Research Council
2012
University of Rostock
2003-2011
Robotic microsurgery has emerged as a new technology with potential benefits for reconstructive surgery. We report the first-in-human use of Symani surgical system to perform lympho-venous and arterial anastomosis lymphatic reconstruction. In five patients, 10 robot-assisted anastomoses were performed. Next anastomoses, two patients received free vascularized lymph node transfer. Motion scaling was set 10×. Visualization either achieved 3D or an optical microscope. All patent confirmed by...
A powerful replica molding methodology to transfer on-demand functional topographies the surface of bacterial cellulose nanofiber textures is presented. With this method, termed guided assembly-based biolithography (GAB), a surface-structured polydimethylsiloxane (PDMS) mold introduced at gas-liquid interface an Acetobacter xylinum culture. Upon fermentation, generated nanofibers are assembled in three-dimensional network reproducing geometric shape imposed by mold. Additionally, GAB yields...
The micron-scale surface topography of implanted materials represents a complementary pathway, independent the material biochemical properties, regulating process biological recognition by cells which mediate inflammatory response to foreign bodies. Here we explore rational design modifications in micron range optimize comprised symmetrical array hexagonal pits interfering with focal adhesion establishment and maturation. When implemented on silicones hydrogels vitro, anti-adhesive...
Fat grafting has been gaining attention in tissue augmentation over the past decade, not only for lipofilling, but also its observed regenerative properties and overall skin texture improvement.The aim of this study was to analyze effect nanofat on scars, wrinkles, discolorations our clinic.Nanofat prepared by a standard emulsification filtration protocol. The resulting liquid injected intradermally or directly into scar tissue. Skin quality evaluated based scoring system, patient...
Robotic systems have recently been introduced into micro- and supermicrosurgery showing potential benefits for reconstructive surgery. After the feasibility safety of using Symani Surgical System® lymphatic microsurgical procedures in humans, we present results first twenty-two patients operated with robot. The main goal study was to determine learning curve . In addition, aimed at exploring robot-assisted anastomosis lymphatic, free flap, nerve reconstruction defining advantages drawbacks...
The mechanical properties of the skin determine tissue function and regulate dermal cell behavior. Yet measuring these remains challenging, as evidenced by large range elastic moduli reported in literature-from below one kPa to hundreds MPa. Here, we reconcile disparate results dedicated experiments at both cellular length scales computational models considering multiscale multiphasic structure. At macroscopic scale, collective behavior collagen fiber network under tension provides...
Micro- and supermicrosurgeries have become standard techniques for lymphatic reconstruction. As increasingly smaller vessels are being targeted, robotic-assisted surgery has emerged as a new approach to push reconstructive limits owing its ability of motion scaling providing better accessibility deep anatomical regions. The precision the robot is achieved at expense operating speed among other variables; therefore, surgeon must weigh enhanced dexterity against additional time cost required...
Abstract Robotic-assisted microsurgery has gained significant attention in recent years following the introduction of two dedicated microsurgical robotic systems specifically designed for this purpose. These feature higher degrees movement and motion scaling which are useful tools, especially when performing surgery areas body difficult to access. been implemented lymphatic as well soft tissue reconstructive at our institution over past 2.5 years. Our study gives an insight into details...
Abstract Lipedema is a chronic adipose tissue disorder characterized by the disproportional subcutaneous deposition of fat and commonly misdiagnosed as lymphedema or obesity. The molecular determinants lipedema remain largely unknown only speculations exist regarding lymphatic system involvement. aim present study to characterize vascular involvement in established lipedema. histological characterization was conducted on anatomically-matched skin biopsies well serum samples from eleven ten...
Abstract The present study investigates the multiphasic nature of mechanical behavior human dermis. Motivated by experimental observations and consideration its composition, a quadriphasic model dermis is proposed, distinguishing solid matrix components, interstitial fluid charged constituents moving within fluid, i.e., anions cations. Compression tensile experiments with without change osmolarity bath are performed to characterize chemo-mechanical coupling in Model parameters determined...
Congenital hypoplasia of facial bones has traditionally been treated by orthognathic surgery. However, the inherent invasiveness surgery often leads to a high complication rate. Facial fat grafting could be less invasive method correct deformities.The aim this study was evaluate results microfat for contouring.This retrospective chart review evaluated 166 patients who were with maxillary and/or mandibular hypoplasia. Pretreatment and posttreatment photographs compared regarding improvement...
Split-thickness skin grafts (STSG) are still the gold standard for treatment of most defects. Hence, there is an ongoing need to improve this procedure. For purpose, we herein analyzed dermal matrices seeded with adipose tissue-derived microvascular fragments (ad-MVF) in a bradythrophic wound model. In additional experiments, were covered autologous STSG 10 days after implantation. Green fluorescence protein (GFP)+ ad-MVF isolated from C57BL/6-Tg(CAG-EGFP)1Osb/J mice and onto...
Advances in the development of robotic systems have recently enabled use technology reconstructive lymphatic surgery. Although advantages microsurgical robots must be weighed carefully against costs, their may allow for smaller surgical approaches and easier access to anatomically deeper structures or even vessels. We report on a case patient with central dilation causing abdominal pain severely reduced physical capacity. Sonography-assisted intranodal injection indocyanine green allowed...
Introduction Up to one-fifth of breast cancer survivors will develop chronic cancer-related lymphoedema (BCRL). To date, complex physical decongestion therapy (CDT) is the gold standard treatment. However, it mainly symptomatic and often ineffective in preventing BCRL progression. Lymphovenous anastomosis (LVA) vascularised lymph node transfer (VLNT) are microsurgical techniques that aim restore lymphatic drainage. This international randomised trial aims evaluate advantages interventions...