Kathryn V. Isaac

ORCID: 0000-0002-9374-031X
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About
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Research Areas
  • Breast Implant and Reconstruction
  • Breast Cancer Treatment Studies
  • Craniofacial Disorders and Treatments
  • Cleft Lip and Palate Research
  • Reconstructive Surgery and Microvascular Techniques
  • Biomedical Text Mining and Ontologies
  • AI in cancer detection
  • Angiogenesis and VEGF in Cancer
  • COVID-19 and healthcare impacts
  • Lymphatic System and Diseases
  • Body Contouring and Surgery
  • Cancer survivorship and care
  • Head and Neck Surgical Oncology
  • Nasal Surgery and Airway Studies
  • Surgical Simulation and Training
  • Radiomics and Machine Learning in Medical Imaging
  • Anatomy and Medical Technology
  • Clinical practice guidelines implementation
  • Global Cancer Incidence and Screening
  • Reconstructive Facial Surgery Techniques
  • Digital Imaging in Medicine
  • Trauma Management and Diagnosis
  • Augmented Reality Applications
  • Wound Healing and Treatments
  • Cardiac, Anesthesia and Surgical Outcomes

University of British Columbia
2018-2025

Ethics and Public Policy Center
2023

University of Manitoba
2022

University of Calgary
2022

Breast Center
2021

Boston Children's Hospital
2017-2019

Harvard University
2018-2019

Children's National
2018

Boston Children's Museum
2018

University of Toronto
2005-2017

OBJECTIVE Comparative effectiveness studies are needed for analyzing the clinical outcomes of treatment sagittal craniosynostosis (SC) with endoscopic suturectomy (ES) or cranial vault remodeling (CVR). METHODS From 2004–2015, patients were consecutively reviewed and data recorded operative details complications. Cranial growth was measured by head circumference percentile (HCP) index (CI) Z-score. Aesthetic compared using Whitaker classification. RESULTS A total 207 nonsyndromic SC treated...

10.3171/2018.5.peds1846 article EN Journal of Neurosurgery Pediatrics 2018-08-03

Post mastectomy radiotherapy (PMRT) is an independent predictor of reconstructive complications. PMRT may alter the timing and type reconstruction recommended. This study aimed to create a machine learning model predict probability requiring after immediate breast (IBR).

10.1097/gox.0000000000005599 article EN cc-by-nc-nd Plastic & Reconstructive Surgery Global Open 2024-02-01

Introduction Up to one-fifth of breast cancer survivors will develop chronic cancer-related lymphoedema (BCRL). To date, complex physical decongestion therapy (CDT) is the gold standard treatment. However, it mainly symptomatic and often ineffective in preventing BCRL progression. Lymphovenous anastomosis (LVA) vascularised lymph node transfer (VLNT) are microsurgical techniques that aim restore lymphatic drainage. This international randomised trial aims evaluate advantages interventions...

10.1136/bmjopen-2024-090662 article EN cc-by-nc-nd BMJ Open 2025-02-01

This Surgical Innovation explores the potential that wearable augmented reality devices have for improving intraoperative imaging, patient outcomes, and surgical workflows.

10.1001/jamasurg.2024.5494 article EN JAMA Surgery 2025-03-12

Comparative effectiveness research is needed to optimize treatment of unilateral coronal synostosis. This study compares perioperative morbidity, ophthalmic, and aesthetic outcomes patients with nonsyndromic synostosis treated by endoscopic suturectomy or fronto-orbital advancement.From 2004 2015, were reviewed data recorded for operative details, reoperations, results using the Whitaker classification, severity strabismus, need surgical correction. Categorical analyzed Fisher's exact test...

10.1097/prs.0000000000005383 article EN Plastic & Reconstructive Surgery 2018-12-31

Circulating angiogenic cells (CACs), represent a potential new therapeutic tool for the treatment of cardiovascular diseases, but their regenerative function is impaired in patients with coronary artery disease (CAD) and cardiac risk factors. The objective this study to assess effect lentiviral overexpression endothelial nitric oxide synthase (eNOS) on activity CACs from CAD In vitro vivo assays were employed evaluate capacity compared derived healthy volunteers. Lentiviral eNOS transduction...

10.1038/mt.2011.52 article EN cc-by-nc-nd Molecular Therapy 2011-04-26
Susan M. Goobie David Zurakowski Kathryn V. Isaac Brad M. Taicher Patrick Fernandez and 90 more Courtney K. Derderian Mali Hetmaniuk Paul A. Stricker Christopher Abruzzese Jesus Apuya Amy B. Beethe Hubert A. Benzon Wendy Binstock Alyssa Brzenski Stefan Budac Veronica Busso Surendrasingh Chhabada Franklin Chiao Franklyn P. Cladis Danielle Claypool Michael Collins Rachel Dabek Nicholas M. Dalesio Ricardo Falconl Allison M. Fernández Patrick Fernandez John E. Fiadjoe Meera Gangadharan Katherine R. Gentry Chris D. Glover Susan M. Goobie Amanda A. Gosman Shannon Grap Heike Gries Allison Griffin Charles M. Haberkern John Hajduk Rebecca Hall Jennifer K. Hansen Mali Hetmaniuk Vincent Hsieh Henry D. Huang Pablo Ingelmo Iskra Ivanova Ranu Jain Michelle Kars Courtney Kowalczyk-Derderian Jane A. Kugler Kristen Labovsky Indrani Lakheeram Andrew Lee José Luis Martínez Brian Masel Eduardo Medellin Petra M. Meier Heather Mitzel Levy Wallis T. Muhly Bridget L. Muldowney Jonathon H. Nelson Julie Nicholson Kim-Phuong Nguyen Thanh Tan Nguyen Olutoyin Olutuye Margaret Owens-Stubblefield Uma Parekh Timothy R. Petersen Vanessa Pohl Julian Post Kim Poteet-Schwartz Jansie Prozesky Srijaya K. Reddy Russell R. Reid Karene Ricketts Daniel Rubens Laura Ryan Rochelle Skitt Codruta Soneru Rachel A. Spitznagel Paul A. Stricker Davinder Singh Neil Raj Singhal Emad Sorial Susan R. Staudt Bobbie L. Stubbeman Wai Sung Tariq Syed Peter Szmuk Brad M. Taicher Douglas Thompson Lisa Tretault Galit Ungar-Kastner Rheana Watts John P. Wieser Karen Wong Lillian Zamora

10.1016/j.bja.2018.10.061 article EN publisher-specific-oa British Journal of Anaesthesia 2018-12-19

We describe our current technique of drainless abdominoplasty using barbed progressive tension sutures. The perioperative management and detailed steps procedure are outlined, including indications for concomitantly performing liposuction repair diastasis the rectus abdominis muscles. This approach reliably improves abdominal contour, minimizes complications, is straightforward to learn perform.

10.1093/asj/sjw241 article EN cc-by Aesthetic Surgery Journal 2017-03-08

After studying this article, the participant should be able to: 1. Appraise and evaluate risk factors for respiratory compromise following oncologic resection. 2. Outline apply an algorithmic approach to reconstruction of chest wall based on defect composition, size, characteristics surrounding tissue. 3. Recognize indications types skeletal stabilization wall. 4. Critically consider, compare, select pedicled free flaps that do not impair residual function or stability.Chest restores...

10.1097/prs.0000000000008882 article EN Plastic & Reconstructive Surgery 2022-02-23

Manually extracted data points from health records are collated on an institutional, provincial, and national level to facilitate clinical research. However, the labour-intensive chart review process puts increasing burden healthcare system budgets. Therefore, automated information extraction is needed ensure timeliness scalability of research data.

10.1186/s12874-022-01583-z article EN cc-by BMC Medical Research Methodology 2022-05-12

Outcomes in aesthetic breast surgery are dependent on preoperative measurements. The accuracy of 3-dimensional (3D) imaging measuring critical landmarks augmentation mammaplasty has not been described.We aimed to determine the predictability 3D compared direct measurements.Two raters measured breasts 28 women using four anthropometric (direct) measurements: sternal notch nipple distance (Sn-N), midline (N-M), inframammary-fold under maximal stretch (N-IMF), and base width (BW). Measurements...

10.1093/asj/sjx232 article EN Aesthetic Surgery Journal 2017-12-19

Background: The COVID-19 pandemic has led to unprecedented challenges and restrictions in surgical access across Canada, including for breast reconstructive services which are an integral component of comprehensive cancer care. We sought determine how being restricted, what strategies may be employed optimize the provision reconstruction through a pan-Canadian evaluation from providers’ perspective. Methods: This was cross-sectional survey Canadian plastic surgeons who perform...

10.1177/22925503211030017 article EN cc-by-nc Plastic Surgery 2021-07-08

Background: Breast reconstructive services are medically necessary, time-sensitive procedures with meaningful health-related quality of life benefits for breast cancer survivors. The COVID-19 global pandemic has resulted in unprecedented restrictions surgical access, including access to services. A national approach is needed guide the strategic use resources during times fluctuating on due demands hospital capacity. Methods: team experts were convened critical review healthcare needs and...

10.1097/gox.0000000000004204 article EN cc-by-nc-nd Plastic & Reconstructive Surgery Global Open 2022-02-01

Patient outcomes in aesthetic breast surgery are highly dependent on measurements used preoperative planning. The purpose of this study is to determine the reliability anthropometric measurements. Four raters measured 28 women using 7 measurements: sternal notch nipple distance (Sn-N), midline (N-M), inframammary-fold under maximal stretch (N-IMF), base width (BW), soft tissue pinch thickness upper pole (STPT:UP), STPT at inframammary fold (STPT:IMF), and anterior pull skin (APSS)....

10.1093/asj/sjv210 article EN Aesthetic Surgery Journal 2015-12-08

PURPOSE Breast cancer relapses are rarely collected by registries because of logistical and financial constraints. Hence, we investigated natural language processing (NLP), enhanced with state-of-the-art deep learning transformer tools large models, to automate relapse identification in the text computed tomography (CT) reports. METHODS We analyzed follow-up CT reports from patients diagnosed breast between January 1, 2005, December 31, 2014. The were curated annotated for presence or...

10.1200/cci.24.00107 article EN JCO Clinical Cancer Informatics 2024-12-01

Following an all-night fast, 45 patients with Parkinson9s disease were examined using certain motor items present in the United Disease Rating Scale. All given a single tablet of carbidopa 25 mg and levodopa 250 re-examined 90 minutes later. In addition to this evaluation, 23 these underwent further scoring over 4-hour period. A significant negative correlation was found between age one important aspect drug-derived benefit: magnitude response. contrast, had no apparent influence on duration...

10.1136/jnnp.56.1.65 article EN Journal of Neurology Neurosurgery & Psychiatry 1993-01-01

Background: After repair of unilateral cleft lip, lateral drift the alar base is expected and may require revision. Although appears wider than on noncleft side, by measurement it could be symmetric or narrow. Is this an optical illusion? Methods: This a retrospective photographic evaluation children who underwent complete lip palate. On submental standardized photographs, raters judged whether position was wider, equal to, narrower side. The true measured photogrammetry frequency...

10.1097/prs.0000000000005480 article EN Plastic & Reconstructive Surgery 2019-03-28

Objective: Infants with syndromic cleft lip and/or palate (CL/P) often require more complex care than their nonsyndromic counterparts. Our purpose was to (1) determine the prevalence of CL/P in patients CHARGE syndrome and (2) highlight factors that affect management this subset children. Design: This is a retrospective review from 1998 2016. Patients: Patients were diagnosed clinically genetically. Main Outcomes Measures: Prevalence determined clinical details tabulated: phenotypic...

10.1177/1055665617738994 article EN The Cleft Palate-Craniofacial Journal 2017-12-14

Sagittal synostosis is the most common form of single suture synostosis. It often results in characteristic calvarial deformities, including a long, narrow head, frontal bossing, bullet-shaped occiput, and an anteriorly placed vertex. Several methods for correcting phenotypic deformities have been described, each with their own advantages challenges. In this study, we describe modification Melbourne method total remodeling scaphocephaly.We conducted retrospective review all consecutive...

10.1097/gox.0000000000001848 article EN cc-by-nc-nd Plastic & Reconstructive Surgery Global Open 2018-07-01

Prominent scars and contractures may form along the seams between adjacent skin grafts. Seams be constructed either by approximating graft edges (AP), or slightly overlapping (OV), but it is not known if one technique creates a less conspicuous seam scar. The purpose of this study was to compare using AP OV techniques. This prospective within-patient within-seam controlled in adult burn patients treated at an American Burn Association-verified center. At application construction, were...

10.1097/bcr.0000000000000433 article EN Journal of Burn Care & Research 2016-01-01
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