A5067798470- Bayesian Modeling and Causal Inference
- Multi-Criteria Decision Making
- Advanced Statistical Methods and Models
- Fuzzy Systems and Optimization
- Coronary Interventions and Diagnostics
- Rough Sets and Fuzzy Logic
- Statistical Methods and Inference
- Retinal Development and Disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Statistical Methods and Bayesian Inference
- Acute Myocardial Infarction Research
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Lung Cancer Diagnosis and Treatment
- Logic, Reasoning, and Knowledge
- Cognitive Radio Networks and Spectrum Sensing
- Distributed Sensor Networks and Detection Algorithms
- Data Management and Algorithms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Pleural and Pulmonary Diseases
- Cardiac Valve Diseases and Treatments
- Aortic aneurysm repair treatments
- Advanced Statistical Process Monitoring
University of Basel
2019-2025
University Hospital of Basel
2020-2025
Institute of Molecular and Clinical Ophthalmology Basel
2021-2024
STMicroelectronics (Italy)
2008-2020
Ludwig-Maximilians-Universität München
2007-2019
University of Hull
2015-2018
Ospedale San Paolo
2018
LMU Klinikum
2010-2014
Snam (Italy)
2008
Nerviano Medical Sciences
2008
The relation between religiosity and well-being is one of the most researched topics in psychology religion, yet directionality robustness effect remains debated. Here, we adopted a many-analysts approach to assess this based on new cross-cultural dataset (N=10,535 participants from 24 countries). We recruited 120 analysis teams investigate (1) whether religious people self-report higher well-being, (2) self-reported depends perceived cultural norms religion (i.e., it considered normal...
Drug-coated balloons (DCBs) are an established treatment strategy for coronary artery disease. Randomized data on the application of DCBs in patients with acute syndrome (ACS) limited. We evaluated impact clinical presentation (ACS versus chronic syndrome) outcomes undergoing DCB or drug-eluting stent (DES) a prespecified analysis BASKET-SMALL 2 trial (Basel Kosten Effektivitäts Trial-Drug-Coated Balloons Versus Drug-Eluting Stents Small Vessel Interventions).BASKET-SMALL randomized 758...
Stargardt disease is a currently untreatable, inherited neurodegenerative that leads to macular degeneration and blindness due loss-of-function mutations in the ABCA4 gene. We have designed dual adeno-associated viral vector encoding split-intein adenine base editor correct most common mutation (c.5882G>A, p.Gly1961Glu). optimized editing human models, including retinal organoids, induced pluripotent stem cell-derived pigment epithelial (RPE) cells, as well adult explants RPE/choroid vitro....
Objective: The clinical diagnosis of respiratory tract infections (RTIs) may result in unnecessary antibiotic treatment due to exams’ low sensitivity and specificity differentiate viral from bacterial costly diagnostic work-ups. Unnecessary consumption drives resistance. We explored whether a rapid influenza-specific polymerase chain reaction (PCR) assay reduced use an emergency room before the COVID-19 pandemic. Methods: conducted observational retrospective study patients with RTI symptoms...
Introduction Up to one-fifth of breast cancer survivors will develop chronic cancer-related lymphoedema (BCRL). To date, complex physical decongestion therapy (CDT) is the gold standard treatment. However, it mainly symptomatic and often ineffective in preventing BCRL progression. Lymphovenous anastomosis (LVA) vascularised lymph node transfer (VLNT) are microsurgical techniques that aim restore lymphatic drainage. This international randomised trial aims evaluate advantages interventions...
ABSTRACT Stargardt disease is a currently untreatable, inherited neurodegenerative that leads to macular degeneration and blindness due loss-of-function mutations in the ABCA4 gene. We have designed dual adeno-associated viral vector split-intein adenine base-editing strategy correct most common mutation (c.5882G>A, p.G1961E). optimized base editing human models, including retinal organoids, iPSC-derived pigment epithelial (RPE) cells, as well adult retinal- RPE/choroid explants vitro....
Background Elevated serum ferritin with/without HFE variants in asymptomatic persons leads frequently to referral for blood donation. Hemochromatosis (p.C282Y/p.C282Y) only requires treatment. We evaluated safety and feasibility of iron removal healthy with elevated using donation procedures. Materials methods Thirty subjects >200 ng/mL (women) or >300 (men) p.C282Y/p.C282Y, p.C282Y/p.H63D p.H63D/p.H63D were randomized weekly phlebotomy (removal 450 mL whole blood)...
SUMMARY Human organoids that mirror their corresponding organs in cell-type diversity present an opportunity to perform large-scale screens for compounds protect disease-affected or damage healthy cell types. However, such have not yet been performed. Here, we generated 20,000 human retinal with GFP-labeled cone photoreceptors. Since degeneration of cones is a leading cause blindness, induced death and screened 2,707 known targets, those saved further damaged cones. We identified kinase...
Dempster’s rule for combining two belief functions assumes the independence of sources information. If this assumption is questionable, I suggest to use least specific combination minimizing conflict among ones allowed by a simple generalization rule. This increases monotonicity reasoning and helps us manage situations dependence. Some properties its usefulness in Bayes’ theorem are then considered.
Current knowledge of recurrence rates after intracranial aneurysm (IA) surgery relies on 2D digital subtraction angiography (DSA), which fails to detect more than 75% small remnants. Accordingly, the discrimination between and growth a remnant remains challenging, actual assessment risk clipped IAs could be inaccurate. The authors report, for first time, 3D-DSA-based long-term durability factor data IA microsurgical clipping.Prospectively collected 305 patients, with total 329 that underwent...
In both classical and Bayesian approaches, statistical inference is unified generalized by the corresponding decision theory. This not case for likelihood approach to inference, in spite of manifest success methods statistics. The goal present work fill this gap, extending order cover making as well. resulting functions generalize usual (such ML estimators LR tests), while maintaining some their key properties, thus providing a theoretical foundation established new methods.
To report the yearly rate of change in macular function patients with Stargardt disease type 1 (STGD1) over 24 months and to establish a new volumetric visual index for use clinical trials investigating efficacy on retinal sensitivity.Design: International, multicenter, prospective cohort study 5 visits every 6 months.A total 233 individuals genetically confirmed STGD1 (≥1 disease-causing ABCA4 variant).The volume (VTOT) beneath sensitivity surface 3-D model hill vision mean (MS) derived...
Abstract Background Data on the safety and efficacy of drug-coated balloon (DCB) compared to drug-eluting stent (DES) in patients with chronic kidney disease (CKD) are scarce, particularly at long term. This pre-specified analysis aimed investigate 3-year DCB versus DES for small coronary artery (< 3 mm) according renal function baseline. Methods BASKET-SMALL-2 was a large multi-center, randomized, controlled trial that tested DCBs ( n = 382) against DESs 376) vessel disease. CKD defined...
Recent data have established non-inferiority of drug-coated balloons (DCB) compared to drug-eluting stents (DES) for treatment small-vessel coronary artery disease. Since vessels in women might anatomical and pathophysiological particularities, the safety DCB strategy among men needs be assessed more detail.