A5102859103- COVID-19 Clinical Research Studies
- Reproductive tract infections research
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Cervical Cancer and HPV Research
- Urinary Tract Infections Management
- COVID-19 Impact on Reproduction
- Dermatology and Skin Diseases
- Ocular Infections and Treatments
- HIV/AIDS Research and Interventions
- Ocular Diseases and Behçet’s Syndrome
- Milk Quality and Mastitis in Dairy Cows
- Antimicrobial Resistance in Staphylococcus
- Inflammasome and immune disorders
- Cutaneous Melanoma Detection and Management
- HIV/AIDS drug development and treatment
- Intraocular Surgery and Lenses
- HIV Research and Treatment
- Ocular Surface and Contact Lens
- Retinal Diseases and Treatments
- Acne and Rosacea Treatments and Effects
- Syphilis Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Regulation of Appetite and Obesity
- Ophthalmology and Visual Impairment Studies
University Hospital of Zurich
2021-2025
University of Zurich
2022-2025
Duke University Health System
2023
University of Warwick
2023
Columbia University
2014-2019
University of California, San Francisco
2015-2019
Royal Derby Hospital
2017
Columbia University Irving Medical Center
2014
Salisbury District Hospital
2014
University of Michigan
2012
Skin is the most common site of Staphylococcus aureus infection. While these infections are self-limited, recurrent common. Keratinocytes and recruited immune cells participate in skin defense against We postulated that S. able to adapt milieu within human keratinocytes avoid keratinocyte-mediated clearance. From a collection isolated from chronically infected patients with atopic dermatitis, we noted 22% had an agr mutant-like phenotype. Using several models infection, demonstrate...
Background: Ethiopia lacked accurate recent national estimates of blindness and low vision. Therefore, prevention control programs face serious problem lack recognition the challenges in tracking achievements towards program goals. Objective: To determine prevalence vision at regional levels Ethiopia. Method: A survey was conducted on a representative population all nine states two city administrations country. The LogMar chart used to presenting visual acuity ophthalmologists determined...
BACKGROUND. Neutralizing antibodies are considered a key correlate of protection by current SARS-CoV-2 vaccines. The manner in which human infections respond to therapeutic antibodies, including convalescent plasma therapy, remains be fully elucidated.
Trachoma remains a leading cause of blindness. Determining the most effective antibiotic treatment strategy is essential for success country-based trachoma control programs.Baseline and 2-month follow-up examinations were performed in trachoma-hyperendemic village. All residents offered azithromycin after baseline was determined. Infection with Chlamydia trachomatis chlamydial load determined by PCR. Clinical status evaluated. A high defined as higher than median among those infection. Risk...
Abstract Background Starting combination antiretroviral therapy (cART) during primary human immunodeficiency virus type 1 (HIV-1) infection results in a smaller HIV-1 latent reservoir, reduced immune activation, and less viral diversity compared to starting cART chronic infection. We report of 4-year study designed determine whether these properties would allow sustained virological suppression after simplification dolutegravir (DTG) monotherapy. Methods EARLY-SIMPLIFIED is randomized,...
purpose. The World Health Organization recommends trichiasis surgery to prevent blindness caused by trachoma; however, recurrence is common. Risk factors for have not been widely studied, particularly in trachoma hyperendemic areas. methods. Three hundred ninety-four persons with Tanzania were examined. Participants had undergone >18 months before the study. Trichiasis and active at study visit assessed. Ocular swabs collected tested Chlamydia trachomatis. Household members examined...
Staphylococcus aureus is the most common cause of skin and soft tissue infections, yet bacterial genetic changes associated with adaptation to human are not well characterized. S. strains isolated from patients chronic colonization intermittent infection were used determine staphylococcal genotypes or phenotypes skin. We demonstrate that polymorphisms in metabolic genes, particularly those involved tricarboxylic acid cycle, fumarate-succinate axis, generation terminal electron transporters,...
Abstract Neutrophilic panniculitis is a rare adverse effect of therapy with selective BRAF inhibitors. We report case neutrophilic in 15‐year‐old girl receiving treatment vemurafenib for brainstem glioma. Clinicians should be aware this but important side vemurafenib. This the first child treated
<b>Aim:</b> To examine the association between epilation and corneal opacity (CO) among trichiasis patients presenting for surgery. <b>Methods:</b> Cross sectional data from STAR trial were utilised. Patients surgery in Wolayta Zone, Ethiopia, evaluated current status. Number of inturned lashes, evidence epilation, level entropion, duration, CO collected. The primary outcome was prevalence CO, stratified by entropion <b>Results:</b> Approximately 10% eyes with mild had regardless Among...
Background. In December 2009, the Department of Health and Human Services guidelines for initiation antiretroviral therapy (ART) changed to include patients with CD4 counts between 350 500 cells/µL. The aims this study were assess uptake recommendation in ART-naive youth human immunodeficiency virus (HIV) describe epidemiology transmitted genotypic drug resistance mutations (DRMs) population. Methods. A multicenter, retrospective cohort ART was performed. Eligible subjects 13–25 years age,...
Abstract Tumor necrosis factor α ( TNF ‐α) antagonists are used in the treatment of numerous autoimmune conditions. Adalimumab is first monoclonal antibody to ‐α and treat juvenile idiopathic arthritis. A growing body literature associates anti‐ therapies with several adverse dermatologic manifestations, including drug‐induced lupus erythematosus (LE). We describe a case cutaneous LE 16‐year‐old girl treated adalimumab for The temporal association between her presenting symptoms initiation...
Trachoma is the leading infectious cause of blindness worldwide. Surgery available to correct trichiasis, which results from repeated episodes infection with C. trachomatis. However, trichiasis recurrence rates post-surgery are very high. Methods for reducing post-surgical need be explored. This paper outlines design Trichiasis, Antibiotics prevent Recurrence (STAR) Clinical Trial currently underway in Ethiopia. The STAR trial, funded by National Eye Institute, a randomized, controlled...
Abstract Background/Objectives Congenital hemangiomas (CH) are a group of benign vascular tumors that present at birth and exhibit variable involution during infancy. do not involute typically solitary patch or plaque‐type grow proportionally with somatic growth. We report case series 9 patients persistent CH, which exhibited uncommon features including segmental involvement, recurrent severe pain, growth via volumetric increase in size apparent increased extent anatomic involvement over...
(1) It was found that sheep pituitary glands contain the greatest amount of LH, while those from cattle had very little. Hog showed great variation with respect to LH content but in all cases contained much less than glands. (2) The inhibiting action preparations paralleled their content. (3) and are approximately equal producing ovarian hypertrophy. produced mainly follicular development caused heavily luteinized ovaries. glands, therefore, more FSH sheep. Beef a poor source FSH. (4)...
The atypical antipsychotic olanzapine is used effectively for treating symptoms of schizophrenia and bipolar disorder. Unwanted effects include slowing the electroencephalogram (EEG) during wakefulness increased circulating levels leptin. mechanisms underlying desired undesired are poorly understood. Sleep modulated by acetylcholine (ACh) in prefrontal cortex, leptin alters cholinergic transmission. This study tested hypothesis that interacts with to regulate ACh release cortex....
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare form of cutaneous characterized by neoplastic α/β T cells infiltrating subcutaneous tissues in lobular pattern. Few data support the optimal treatment regimen for patients, given rarity this condition, and even fewer describe when diagnosed during pregnancy. We case SPTCL pregnant patient who achieved clinical remission after with corticosteroid monotherapy. Our suggests that corticosteroids should be considered as first-line...