A5013201018- Mesenchymal stem cell research
- Bone health and treatments
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Extracellular vesicles in disease
- Infective Endocarditis Diagnosis and Management
- Osteoarthritis Treatment and Mechanisms
- Bone fractures and treatments
- Orthopedic Infections and Treatments
- Sarcoma Diagnosis and Treatment
- Management of metastatic bone disease
- Antifungal resistance and susceptibility
- HIV/AIDS Research and Interventions
- Nosocomial Infections in ICU
- Bone and Joint Diseases
- Fungal Infections and Studies
- Cancer Diagnosis and Treatment
- HIV, Drug Use, Sexual Risk
- Potassium and Related Disorders
- Anatomy and Medical Technology
- RNA Interference and Gene Delivery
- Surgical site infection prevention
- Glioma Diagnosis and Treatment
- Pain Management and Opioid Use
- Facial Trauma and Fracture Management
Houston Methodist
2020-2024
Methodist Hospital
2020-2024
The Ohio State University Wexner Medical Center
2024
Methodist Hospital
2019-2023
The Ohio State University
2023
Bryan College
2019-2022
Texas A&M Health Science Center
2022
Texas A&M University
2019
Sesame Workshop
2015
Columbia University Irving Medical Center
2012-2014
Invasive mold infections (IMIs) are a leading cause of mortality in immunocompromised children, yet there has never been an international epidemiologic investigation pediatric IMIs. This international, prospective cohort study was performed to characterize the epidemiology, antifungal therapy, and outcomes Children (≤18 years) with proven or probable IMIs were enrolled between August 2007 May 2011 at 22 sites. Risk factors, underlying diagnoses, treatments recorded. Outcomes assessed 12...
Bone marrow aspirate (BMA) is a common source for harvesting mesenchymal stem cells (MSCs), other progenitor cells, and associated cytokines growth factors to be used in the biologic treatment of various orthopaedic pathologies. The commonly centrifuged into concentrated volume that can immediately administered patient using commercially available kits. However, handling efficacy BMA concentrate (BMAC) are still controversial.To characterize versus BMAC MSC quantity, potency, cytokine...
Focal chondral lesions of the knee are most frequent type trauma in younger patients and associated with a high risk developing early posttraumatic osteoarthritis. The only current clinical solutions include microfracture, osteochondral grafting, autologous chondrocyte implantation. Cartilage tissue engineering based on biomimetic scaffolds has become an appealing strategy to repair cartilage defects. Here, chondrogenic collagen-chondroitin sulfate scaffold is tested orthotopic Lapine vivo...
A multi-national prospective study of pediatric patients with invasive candidiasis between August 2007 and September 2012 was performed included 441 infections. Variation in infecting Candida species antifungals used noted US non-US sites. Antifungal-associated adverse events were most common polyene use.
Abstract The emergence of cell‐based therapeutics, specifically the use mesenchymal stromal/stem cells (MSCs), stands to significantly affect future targeted drug delivery technologies. MSCs represent a unique cell type, offering more than only regenerative potential but also site‐specific inflammatory targeting and tissue infiltration. In this study, versatile multicomponent platform, combining MSC tropism with multistage nanovector (MSV)‐mediated payload delivery, is debuted. It...
Background. In December 2009, the Department of Health and Human Services guidelines for initiation antiretroviral therapy (ART) changed to include patients with CD4 counts between 350 500 cells/µL. The aims this study were assess uptake recommendation in ART-naive youth human immunodeficiency virus (HIV) describe epidemiology transmitted genotypic drug resistance mutations (DRMs) population. Methods. A multicenter, retrospective cohort ART was performed. Eligible subjects 13–25 years age,...
Research has demonstrated that adherence to antiretroviral therapy (ART) results in lower rates of morbidity and mortality associated with HIV infection, yet remains a challenge resource-limited settings like the Dominican Republic. Clínica de Familia La Romana addressed this problem an education-based program for adult patients new ART, retrospective cohort study aimed evaluate impact intervention. Appointment biological markers were assessed cases controls through 12 months. A total 101...
Cartilage repair in osteoarthritic patients remains a challenge. Identifying resident or donor stem/progenitor cell populations is crucial for augmenting the low intrinsic potential of hyaline cartilage. Furthermore, mediating interaction between these cells and local immunogenic environment thought to be critical long term regeneration. In this study we propose articular cartilage progenitor/stem (CPSC) as valid alternative bone marrow-derived mesenchymal stem (BMMSC) strategies after...
Abstract Bone is a highly dynamic tissue. Hence, diseases affecting bone tissue, such as cancer (primary tumors and metastases), osteoporosis, genetic conditions present many challenges for traditional therapies, leading to poor therapeutic outcome. Nano‐delivery systems are innovative tools used the treatment of variety due their ability deliver various cargos specifically target disease sites, including difficult ones like bone. A nano‐delivery strategies recently explored treat...
Implant-related hypersensitivity is emerging as a causative factor potential source of total knee arthroplasty (TKA) failure. Mechanistically, this type IV reaction (T4HR) mediated by effector T-cells, macrophages, and leukocytes that infiltrate to the site implant react metal exposure induce inflammatory tissue damage.A case-control study was performed where cortical bone taken at time revision surgery for all patients operated on primary TKA in which allergy suspected cases done presumed...
Purpose: To determine the prevalence and risk factors for dysplasia in an urban population of HIV-infected young men who have sex with (YMSM) to adherence guidelines anal cytology screening. Methods: The electronic medical record was utilized collect pre-existing demographic information, history, laboratory data, results. Results: Among 60 subjects (mean age 21.2 years) at their first diagnostic cytology, 32 (53.3%) had cytological abnormality 28 (46.7%) normal cytology. abnormal results...
Surgeons are looking to use computer computer-assisted surgery (CAS) in total hip arthroplasty (THA) order quantify leg length measurement, angular cup placement, and enhance stability provide enhanced accuracy implant placement. As a result, CAS THA is gaining popularity. This technology employs the of pins provides surgeon with real-time feedback on positioning intraoperatively. Previous knee (TKA) literature has reported pin-associated complications such as infections, neuropraxia, suture...
A 65-year-old male with a history of ischemic strokes, seizures, and subarachnoid hemorrhage presented 4-week progressive diplopia, vertigo, nausea, vomiting. Magnetic resonance imaging (MRI) revealed <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mn>2.5</mml:mn><mml:mo>×</mml:mo><mml:mn>1.8</mml:mn><mml:mo>×</mml:mo><mml:mn>1.7</mml:mn></mml:math> cm posterior fossa mass arising from the roof 4 th ventricle extending into cerebellar vermis. Posterior craniotomy...
Osteosarcoma (OS) is the most common bone tumor in pediatrics. After resection, allografts or metal endoprostheses reconstruct voids, and systemic chemotherapy used to prevent recurrence. This urges development of novel treatment options for regeneration after excision. We utilized a previously developed biomimetic, biodegradable magnesium-doped hydroxyapatite/type I collagen composite material (MHA/Coll) promote presence chemotherapy. also performed experiments determine if human...
Osteosarcoma (OS) is the most common primary malignant bone tumor, and current standard of care for OS includes neoadjuvant chemotherapy, followed by an R0 surgical resection then postsurgical adjuvant chemotherapy. Bone reconstruction following particularly challenging due to size voids because patients are treated with systemic which theoretically could impact formation. We hypothesized that osteogenic material be used in order induce regeneration when or chemotherapy given. utilized a...
Iron deficiency is the most common etiology of anemia worldwide and often managed with varying methods iron supplementation. Although rare, oral supplementation can perpetuate by causing gastric ulceration upper gastrointestinal bleeding in high-risk populations. However, this complication has not been previously described intravenous We present a case 63-year-old male severe on biweekly infusions weekly packed red blood cell transfusions who presented melena over several months. Upper...
OPINION article Front. Surg., 27 March 2020 | https://doi.org/10.3389/fsurg.2020.00013
Due to their immunosuppressive potential and ability differentiate into multiple musculoskeletal cell lineages, mesenchymal stromal cells (MSCs) became popular in clinical trials for the treatment of disorders. The aim this study was isolate characterize native populations MSCs from human cortical cancellous bone posterior elements lumbar spine determine what source yields better quality quantity be potentially used spinal fusion repair. We were able show that trabecular had typical MSC...
In article number 2100152, the group of Taraballi Francesca summarize current state art nano-formulations for orthopedics applications including bone cancers and metastasis but also most unresolved genetic conditions. With this work authors want to point light on challenging use nanotechnologies musculoskeletal disorders including, not only, regulatory limitations.