A5100628988- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Parvovirus B19 Infection Studies
- Polyomavirus and related diseases
- Lymphoma Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Cancer Treatment and Pharmacology
- Herpesvirus Infections and Treatments
- Hematopoietic Stem Cell Transplantation
- Neutropenia and Cancer Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Renal Transplantation Outcomes and Treatments
- Chronic Myeloid Leukemia Treatments
- Respiratory viral infections research
- Rheumatoid Arthritis Research and Therapies
- Antifungal resistance and susceptibility
- COVID-19 Impact on Reproduction
- Clinical Nutrition and Gastroenterology
- Peptidase Inhibition and Analysis
- HER2/EGFR in Cancer Research
- Chronic Lymphocytic Leukemia Research
- Esophageal Cancer Research and Treatment
Guy's and St Thomas' NHS Foundation Trust
2020-2024
Children's Hospital of Pittsburgh
2014-2024
University of Pittsburgh
2014-2024
University of Pittsburgh Medical Center
1993-2024
York Teaching Hospital NHS Foundation Trust
2022-2024
Washington University in St. Louis
2024
Harrogate and District NHS Foundation Trust
2024
Yokohama National University
2024
NIHR Manchester Biomedical Research Centre
2023
Manchester University NHS Foundation Trust
2023
Purpose This randomized, multicenter trial compared first-line trastuzumab plus docetaxel versus alone in patients with human epidermal growth factor receptor 2 (HER2) –positive metastatic breast cancer (MBC). Patients and Methods were randomly assigned to six cycles of 100 mg/m every 3 weeks, or without 4 mg/kg loading dose followed by weekly until disease progression. Results A total 186 received at least one the study drug. Trastuzumab was significantly superior terms overall response...
Purpose This phase II study investigated the efficacy, safety, and pharmacokinetics of trastuzumab monotherapy given as first-line treatment once every 3 weeks (3-weekly) in women with human epidermal growth factor receptor 2 (HER2) -positive metastatic breast cancer (MBC). Patients Methods previously untreated HER2-positive MBC received a loading dose trastuzumab, 8 mg/kg intravenously (IV) then 6 IV at 3-week intervals until disease progression or patient withdrawal. Results In total, 105...
The recent identification of an outbreak 2019- novel Coronavirus is currently evolving, and the impact on transplantation unknown. However, it imperative that we anticipate potential transplant community in order to avert severe consequences this infection both contacts patients.
<h3>Importance</h3> Bacteremia causes considerable morbidity among children with acute leukemia and those undergoing hematopoietic stem cell transplantation (HSCT). There are limited data on the effect of antibiotic prophylaxis in children. <h3>Objective</h3> To determine efficacy risks levofloxacin receiving intensive chemotherapy for or HSCT. <h3>Design, Setting, Participants</h3> In this multicenter, open-label, randomized trial, patients (6 months-21 years) were enrolled (September...
To evaluate the incidence of posttransplant lymphoproliferative disease (PTLD) and risk factors impact this complication on survival outcomes in a large cohort liver transplant recipients at single institution.Liver transplantation has been accepted as therapeutic option for patients with end-stage since 1983, part due to availability reliance use nonspecifically directed immunosuppression. However, predicted subsequently verified 1968, an increased certain de novo malignancies observed,...
Objective. A 4-year longitudinal study of school-aged children was conducted to describe the clinical characteristics and epidemiologic features infections with group streptococci (GAS). Methods. Between 1998 2002, surveillance throat cultures were performed twice per month (October May) for a cohort elementary school in Pittsburgh, Pennsylvania. In addition, obtained during any respiratory illness. Erythromycin clindamycin susceptibility testing all isolates. Molecular typing...
Abstract Objective To compare work disability and job loss in early rheumatoid arthritis (RA) patients receiving adalimumab plus methotrexate (adalimumab + MTX) versus MTX alone. Methods In this multicenter, randomized, controlled trial, with RA for <2 years who had never taken self‐reported impairment were randomized to or placebo 56 weeks. Primary outcome was of any cause and/or imminent at after week 16. Secondary outcomes included disease activity, function (Health Assessment...
These recommendations provide a data-supported approach to establishing guidelines. They are based on the following: (1) formal review and analysis of recently published world literature topic (via PubMed/MEDLINE search from 1996 July 2011 limited English language, human studies, children 0-18 years old); (2) A Manual for Assessing Health Practices Designing Practice Guidelines American College Physicians1; (3) guideline policies, including Association Study Liver Diseases policy development...
Persistently febrile neutropenic children at risk for invasive fungal infections receive empiric antifungal therapy as a standard of care. However, little is known about the role echinocandins and liposomal amphotericin B (L-AmB) in pediatric patients.Patients between ages 2 to 17 years with persistent fever neutropenia were randomly assigned caspofungin (70 mg/m loading dose on day 1, then 50 daily [maximum 70 mg/d]) or L-AmB (3 mg/kg daily) 2:1 ratio. Evaluation safety was primary...
Despite clinical and laboratory screening of potential donors for transmissible disease, unexpected transmission disease from donor to recipient remains an inherent risk organ transplantation. The Disease Transmission Advisory Committee (DTAC) was created review classify reports use this information inform national policy improve patient safety. From January 1, 2008 December 31, 2017, the DTAC received 2185 reports; 335 (15%) were classified as a proven/probable event. Infections transmitted...
Abstract Growing evidence suggests receipt of live‐attenuated viral vaccines after solid organ transplant (SOT) has occurred and is safe needed due to lapses in herd immunity. A 2‐day consortium experts infectious diseases, transplantation, vaccinology, immunology was held with the objective review create expert recommendations for clinicians when considering live post‐SOT. For consideration VV MMR post‐transplant, exists only kidney liver recipients. vaccine post‐SOT, consider vaccination...
Abstract Allogeneic hematopoietic cell transplantation (HCT) is the only curative therapy for myelofibrosis (MF). In this large multicenter retrospective study, overall survival (OS) in MF patients treated with allogeneic HCT (551 patients) and without (non-HCT) (1377 was analyzed Cox proportional hazards model. Survival analysis stratified by Dynamic International Prognostic Scoring System (DIPSS) revealed that first year of treatment arm assignment, due to upfront risk transplant-related...
There is increasing evidence for the use of exercise in cancer patients and data supporting enhanced tumour volume reduction following chemotherapy animal models. To date, there no reported histopathological a similar oncological benefit oesophageal cancer.A prospective non-randomised trial compared structured prehabilitation intervention during neoadjuvant surgery versus conventional best-practice patients. Biochemical body composition analyses were performed at multiple time points....
Treatments for osteoarthritis (OA) are limited. Previous small studies suggest that the antirheumatic drug methotrexate may be a potential treatment OA pain.
Objective To determine the factors that predict clinical outcome at 6 months for patients with mild, early inflammatory arthritis. Methods Sixty-three untreated, arthritis were given a single dose of corticosteroids presentation. Administration was intramuscular if disease polyarticular (n = 53) or intraarticular had <5 synovitic joints 10). The primary measure remission persistence following injection. Results At injection, 49 63 (78%) persistent joint disease. other 14 (22%) remission....
Background. Bacterial translocation (BT) has been suggested to beresponsible for the high incidence of infections occurring after small boweltransplantation (SBTx). overgrowth, alteration mucosalbarrier function as a consequence preservation injury or acute rejection(AR), and potent immunosuppression are all associated with BT. The aim thisstudy was evaluate quantify correlation BT theseevents. Methods. Fifty pediatric SBTx recipients on tacrolimus andprednisone were analyzed. Blood, stool,...
The development of EBV infection and PTLD is normally associated with a high load in peripheral blood. Often, children undergoing primary or reactivation subsequent to ITx will have chronically elevated loads. To better understand this phenomenon its consequences, we retrospectively reviewed the records who underwent (either isolated part multivisceral transplantation) at our center from 1992 2007, identify chronic carriers population. CHL state was defined as presence for >50% samples...
Early experience with intestinal and multivisceral transplantation was plagued high risk of rejection posttransplant lymphoproliferative disorders (PTLD). To improve outcome, innovative management immunosuppressant strategies were sequentially evolved.With initiation the program in 1990, serial monitoring Epstein-Barr-Viral load introduced 1994 adoption preemptive antiviral therapy. In 1995, cyclophosphamide or daclizumab induction added to tacrolimus-steroid-based multiple drug...
Posttransplant lymphoproliferative disorder (PTLD) causes significant morbidity and mortality in pediatric recipients of liver transplantation (LT).Describe the incidence PTLD symptomatic Epstein-Barr virus (SEBV) disease a large multicenter cohort children who underwent LT with focus on risk factors changes over time. SEBV were prospectively determined 2283 subjects had undergone for first time at least 1 year follow-up Studies Pediatric Liver Transplantation database. was defined specific...
Cutaneous sclerosis occurs in 20% of patients with chronic graft-versus-host disease (GVHD) and can compromise mobility quality life.We conducted a prospective, multicenter, randomized, two-arm phase II crossover trial imatinib (200 mg daily) or rituximab (375 mg/m(2) i.v. weekly × 4 doses, repeatable after 3 months) for treatment cutaneous diagnosed within 18 months (NCT01309997). The primary endpoint was significant clinical response (SCR) at 6 months, defined as quantitative improvement...