A5057005677- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Monoclonal and Polyclonal Antibodies Research
- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Immune Response and Inflammation
- Platelet Disorders and Treatments
- Erythropoietin and Anemia Treatment
- T-cell and B-cell Immunology
- Immune cells in cancer
- Chronic Lymphocytic Leukemia Research
- Erythrocyte Function and Pathophysiology
- Virus-based gene therapy research
- Zebrafish Biomedical Research Applications
- Neutropenia and Cancer Infections
- Neonatal Respiratory Health Research
- Glycosylation and Glycoproteins Research
- Health and Medical Research Impacts
- RNA Interference and Gene Delivery
- Hemoglobinopathies and Related Disorders
- 3D Printing in Biomedical Research
- Blood disorders and treatments
Spark Therapeutics (United States)
2023
Parks Victoria
2021
Valent BioSciences (United States)
2021
TetraLogic Pharmaceuticals (United States)
2013-2017
Amgen (United States)
2003-2015
Stanford University
2014
Palmetto Hematology Oncology
2010
The Kids Research Institute Australia
2002-2007
The University of Western Australia
2000-2007
Whitehead Institute for Biomedical Research
2005
A purified recombinant human granulocyte-macrophage colony stimulating factor (rH GM-CSF) was a powerful stimulator of mature eosinophils and neutrophils. The rH GM-CSF enhanced the cytotoxic activity neutrophils against antibody-coated targets, stimulated phagocytosis serum-opsonized yeast by both cell types in dose-dependent manner, neutrophil-mediated iodination presence zymosan. In addition, N-formylmethionylleucylphenylalanine(FMLP)-stimulated degranulation Cytochalasin B pretreated...
The assumption that drug repurposing efficiently delivers new drugs ignores the realities of development required to achieve regulatory approval.
Gene targeting was used to create mice with a null mutation of the gene encoding common beta subunit (beta C) granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin 3 (IL-3; multi-CSF), and 5 (IL-5) receptor complexes C-/- mice). High-affinity binding GM-CSF abolished in bone marrow cells, while cells from heterozygous animals C+/- mice) showed an intermediate number high-affinity receptors. Binding IL-3 unaffected, confirming that IL-3-specific chain remained intact....
We have studied a leukemic stem-cell line, DU.528, that is able to differentiate into myeloid and lymphoid cells. The cells translocation between chromosomes 1 14, t(1;14)(p33;q11), which we molecularly cloned sequenced. Initial screening used joining (J)-segment probes from the T-cell receptor (TCR) alpha- delta-chain loci. In apparent concert with translocation, deletion has occurred diversity (D)-region genes D delta 2. 2 was observed on derivative chromosome [der(1)] der(14) of...
A purified murine lymphokine, eosinophil differentiation factor (EDF), was found to be a selective stimulus for the clonal proliferation and of progenitor cells, establishing it as colony-stimulating (Eo-CSF). EDF also active on human progenitors mature blood eosinophils, but had no effect neutrophil or macrophage precursor nor neutrophils. In culture bone marrow stimulated equal numbers sizes colonies develop when compared with placental conditioned medium, source CSFs, suggesting that all...
Significance Current antiviral treatments for chronic hepatitis B virus (HBV) infection are effective in suppressing production of virus, but they have poor efficacy promoting the elimination infection. Hence, most patients with HBV maintained on therapies indefinitely. There is much interest identifying that promote clearance infected hepatocytes, thus purging DNA reservoir liver. Here, we show clinical-stage drug birinapant, which antagonizes host cell inhibitor apoptosis proteins (cIAPs),...
Hepatitis B virus (HBV) infection can result in a spectrum of outcomes from immune-mediated control to disease progression, cirrhosis, and liver cancer. The host molecular pathways that influence contribute these need be defined. Using an immunocompetent mouse model chronic HBV infection, we identified some the cellular factors impact on outcomes. Here, show inhibitor apoptosis proteins (cIAPs) attenuate TNF signaling during hepatitis they restrict death infected hepatocytes, thus allowing...