A5058995243- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- SARS-CoV-2 and COVID-19 Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycobacterium research and diagnosis
- COVID-19 Clinical Research Studies
- Transplantation: Methods and Outcomes
- Polyomavirus and related diseases
- Renal Transplantation Outcomes and Treatments
- Neutropenia and Cancer Infections
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Clostridium difficile and Clostridium perfringens research
- SARS-CoV-2 detection and testing
- Hepatitis C virus research
- Liver Disease and Transplantation
- Respiratory viral infections research
- Hematological disorders and diagnostics
- Tuberculosis Research and Epidemiology
- COVID-19 epidemiological studies
- HIV/AIDS drug development and treatment
- Infectious Diseases and Tuberculosis
- Long-Term Effects of COVID-19
- Viral gastroenteritis research and epidemiology
- Bacterial Identification and Susceptibility Testing
University of Michigan
2015-2025
Michigan Medicine
2008-2024
Indian Council of Medical Research
2020
Michigan State University
2018
Lakeland Health
2018
Michigan Department of Health and Human Services
2018
Henry Ford Hospital
2018
Mayo Clinic
2018
Klinik und Poliklinik für Strahlentherapie und Radioonkologie
2015
Charité - Universitätsmedizin Berlin
2015
Abstract Background Severe coronavirus disease 2019 (COVID-19) can manifest in rapid decompensation and respiratory failure with elevated inflammatory markers, consistent cytokine release syndrome for which IL-6 blockade is an approved treatment. Methods We assessed effectiveness safety of tocilizumab a single-center cohort patients COVID-19 requiring mechanical ventilation. The primary endpoint was survival probability postintubation; secondary analyses included ordinal illness severity...
Infectious diseases are important causes of morbidity and mortality in patients with cancer. The NCCN Clinical Practice Guidelines Oncology (NCCN Guidelines) for Prevention Treatment Cancer-Related Infections characterize the major pathogens to which cancer susceptible, a focus on prevention, diagnosis, treatment common opportunistic infections. This portion guidelines highlights sections antifungal antiviral prophylaxis. Antifungal prophylaxis recommendations have expanded over past few...
Patients with cancer are at increased risk for developing infectious complications during the course of their disease and treatment. The following sections NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) Prevention Treatment Cancer-Related Infections provide an overview factors complications, recommendations categorization, strategies prevention infections high-risk patient populations cancer. Individualized evaluation incorporation preventative measures essential components...
Background. Cytomegalovirus (CMV) disease remains an important problem in solid-organ transplant recipients, with the greatest risk among donor CMV-seropositive, recipient-seronegative (D+/R−) patients. CMV-specific cell-mediated immunity may be able to predict which patients will develop CMV disease.
Although sarcopenia (muscle loss) is associated with increased mortality after liver transplantation, its influence on other complications less well understood. We examined the association between and risk of severe posttransplant infections among adult transplant recipients. By calculating total psoas area (TPA) preoperative computed tomography scans, we assessed 207 The presence or absence a infection was determined by review medical chart. overall survival also assessed. identified 196...
The aim of this document is to provide a concise scientific review the currently available COVID-19 vaccines and those in development, including mRNA, adenoviral vectors, recombinant protein approaches. anticipated use patients with chronic liver disease (CLD) transplant (LT) recipients reviewed practical guidance provided for health care providers involved LT about vaccine prioritization administration. Pfizer Moderna mRNA are associated 94%-95% efficacy compared placebo against COVID-19....
We describe a case of proven transmission SARS-CoV-2 from lung donor to recipient. The had no clinical history or findings suggestive infection with and tested negative by reverse transcriptase polymerase chain reaction (RT-PCR) on nasopharyngeal (NP) swab obtained within 48 h procurement. Lower respiratory tract testing was not performed. recipient developed fever, hypotension, pulmonary infiltrates posttransplant day (PTD) 3, RT-PCR for an NP specimen non-reactive, but positive...
Background. To improve our understanding of risk factors, management, diagnosis, and outcomes associated with histoplasmosis after solid organ transplant (SOT), we report a large series occurring SOT. Methods. All cases in SOT recipients diagnosed between 1 January 2003 31 December 2010 at 24 institutions were identified. Demographic, clinical, laboratory data collected. Results. One hundred fifty-two identified: kidney (51%), liver (16%), kidney/pancreas (14%), heart (9%), lung (5%),...
Infection is a major complication of hematopoietic cell transplantation. Prolonged neutropenia and graft-versus-host disease are the 2 complications with an associated risk for infection, these differ according to graft source. A phase 3, multicenter, randomized trial (Blood Marrow Transplant Clinical Trials Network [BMT CTN] 0201) transplantation bone marrow (BM) versus peripheral blood stem cells (PBSC) from unrelated donors showed no significant differences in 2-year survival between...
Despite clinical and laboratory screening of potential donors for transmissible disease, unexpected transmission disease from donor to recipient remains an inherent risk organ transplantation. The Disease Transmission Advisory Committee (DTAC) was created review classify reports use this information inform national policy improve patient safety. From January 1, 2008 December 31, 2017, the DTAC received 2185 reports; 335 (15%) were classified as a proven/probable event. Infections transmitted...
The Organ Procurement Transplant Network Disease Transmission Advisory Committee (DTAC), a multidisciplinary committee, evaluates potential donor-derived transmission events (PDDTE), including infections and malignancies, to assess for donor transmitted events.Reports of unexpected PDDTE in 2013 were fully reviewed by DTAC. A standardized algorithm was used each from given classify individual recipient that donor.Of 443 total submitted, 159 triaged not sent out the full Of 284 evaluated...
ABSTRACT Background Severe COVID-19 can manifest in rapid decompensation and respiratory failure with elevated inflammatory markers. This presentation is consistent cytokine release syndrome chimeric antigen receptor T cell therapy, for which IL-6 blockade approved treatment. Methods We assessed effectiveness safety of tocilizumab a single-center cohort patients requiring mechanical ventilation. The primary endpoint was survival probability post-intubation; secondary analyses included an...
During July 7-11, 2023, CDC received reports of two patients in different states with a tuberculosis (TB) diagnosis following spinal surgical procedures that used bone allografts containing live cells from the same deceased donor. An outbreak associated similar product manufactured by tissue establishment (i.e., manufacturer) occurred 2021. Because concern these cases represented second outbreak, and Food Drug Administration worked to determine this was obtained donor one implicated 2021...
A 23-year-old South African man presented to an emergency department with a 2-day history of fever, mild dyspnea, headache, nausea, and myalgias. His symptoms had begun 5 days after he traveled Colorado ski friends.
The Public Health Service "Increased Risk" (PHS IR) designation identifies donors at increased risk of transmitting hepatitis B, C, and human immunodeficiency virus. Although the remains very low in era nucleic acid testing, we hypothesized that this label may result decreased organ utilization.Organ Procurement Transplantation Network data were used to compare utilization rates between PHS-IR non-PHS-IR donors, as well export variation utilization.Among adult standard criteria 2010 2013...
The optimal treatment for respiratory syncytial virus (RSV) infection in adult immunocompromised patients is unknown. We assessed the management of RSV and other non-influenza viruses Midwestern transplant centers.A survey assessing strategies viral infections was sent to 13 centers.Multiplex polymerase chain reaction assay used diagnosis 11/12 centers. Eight 12 centers inhaled ribavirin (RBV) some patient populations. Barriers included cost, safety, lack evidence, inconvenience. Six...
Few options are available for cytomegalovirus (CMV) treatment in transplant recipients resistant, refractory, or intolerant to approved agents. Letermovir (LET) is prophylaxis hematopoietic cell (HCT) recipients, but little known about efficacy CMV infection. We conducted an observational study determine the patterns of use and outcome LET infection recipients.Patients who received were identified at 13 centers. Demographic data collected.Twenty-seven solid organ 21 HCT (one dual) from...
Abstract Immunocompromised patients with B-cell deficiencies are at risk for prolonged symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We describe 4 treated malignancies B-cell-depleting therapies who developed persistent SARS-CoV-2 infection and had resolution of symptoms following an extended course nirmatrelvir/ritonavir.
Post-transplantation histoplasmosis may be acquired via inhalation, result from endogenous reactivation, or derived the allograft. The Histoplasma and Aspergillus enzyme-linked immunoassays are increasingly being relied upon for rapid diagnosis of fungal infections, especially in immunocompromised patients. We describe 4 cases solid organ transplant recipients who had a falsely positive galactomannan (GM) obtained serum bronchoalveolar lavage (BAL) fluid. also report our experience, testing...
The optimal means for detecting and managing liver transplantation (LT) patients with latent tuberculosis (TB) are not well defined. Our study aims were to (1) determine the frequency risk factors of TB in a large cohort consecutive adult LT candidates (2) safety efficacy isoniazid treatment recipients TB. A review assessed by skin testing using purified protein derivative (PPD; January 2004 September 2008) or interferon-γ release assay QuantiFERON-TB Gold (QFT; March 2008 October 2009) was...
In February 2013, the Organ Procurement and Transplantation Network mandated that transplant centers perform screening of living kidney donors prior to transplantation for Strongyloides, Trypanosoma cruzi West Nile virus (WNV) infection if donor is from an endemic area. However, specific guidelines were not provided, such as optimal testing modalities, timing donation appropriate selection donors. this regard, American Society Infectious Diseases Community Practice, together with...