A5020393491- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Neutropenia and Cancer Infections
- Antibiotic Use and Resistance
- Clostridium difficile and Clostridium perfringens research
- Antibiotics Pharmacokinetics and Efficacy
- Antifungal resistance and susceptibility
- Streptococcal Infections and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 Clinical Research Studies
- Infective Endocarditis Diagnosis and Management
- Long-Term Effects of COVID-19
- Mycobacterium research and diagnosis
- SARS-CoV-2 and COVID-19 Research
- Surgical site infection prevention
- Fungal Infections and Studies
- Antibiotic Resistance in Bacteria
- Hematopoietic Stem Cell Transplantation
- Influenza Virus Research Studies
- Drug-Induced Adverse Reactions
- Urinary Tract Infections Management
- Viral gastroenteritis research and epidemiology
- Medication Adherence and Compliance
- Patient Satisfaction in Healthcare
- Actinomycetales infections and treatment
Yale New Haven Hospital
2016-2025
Yale University
2015-2025
Smilow Cancer Hospital
2024
Yale Cancer Center
2024
Yale New Haven Health System
2020-2021
Museum of Heilongjiang Province
2021
Services Hospital
2019
University of Maryland, Baltimore
2017
Office of Infectious Diseases
2010
University of Genoa
2002
Infectious diseases are important causes of morbidity and mortality in patients with cancer. The NCCN Clinical Practice Guidelines Oncology (NCCN Guidelines) for Prevention Treatment Cancer-Related Infections characterize the major pathogens to which cancer susceptible, a focus on prevention, diagnosis, treatment common opportunistic infections. This portion guidelines highlights sections antifungal antiviral prophylaxis. Antifungal prophylaxis recommendations have expanded over past few...
Abstract Objective: Influenza vaccine receipt by healthcare workers (HCWs) is important because HCWs are at risk for occupational exposure to influenza and may act as vectors in the nosocomial transmission of influenza. were surveyed determine whether belief commonly held misconceptions was associated with acceptance. Design: Cross-sectional study. Setting: A large urban teaching hospital. Method: self-administered survey used assess nursing physician staff knowledge, current vaccination...
The SARS-CoV-2 virus has emerged and rapidly evolved into a current global pandemic. Although bacterial fungal coinfections have been associated with COVID-19, little is known about parasitic infection. We report case of COVID-19 patient who developed disseminated strongyloidiasis following treatment high-dose corticosteroids tocilizumab. Screening for Strongyloides infection should be pursued in individuals originate from endemic regions before initiating immunosuppressive therapy.
Catheter-associated urinary tract infections (CAUTIs) represent the most common nosocomial infection. The authors' baseline rate of CAUTI for general medical service was elevated at 36 per 1000 catheter-days. literature has consistently linked inappropriate catheter use with development CAUTI. data also revealed a high indwelling catheters. Using dual modalities technology through prompts in computerized order/entry system and handheld bladder scanners, as well combination staff education...
Background. Babesiosis is an emerging tickborne malaria-like infection principally caused by Babesia microti. This typically resolves either spontaneously or after administration of a 7–10-day course azithromycin plus atovaquone clindamycin quinine. Although certain highly immunocompromised patients may respond suboptimally to these drug regimens, unlike the situation with malaria there has been no reported evidence that cause treatment failure drug-resistant strains B. Methods. Emergence...
Per prescribing guidance, remdesivir is not recommended for SARS-CoV-2 in patients with renal disease given the absence of safety data this patient population. This study was a multicenter, retrospective chart review hospitalized who received remdesivir.
There is an increased risk of infection in patients with cancer that results higher morbidity and mortality. Several factors can predispose these to infectious complications. Some such include immunocompromised states like neutropenia, allogeneic hematopoietic cell transplantation, graft-versus-host disease, while others immunosuppressive agents corticosteroids, purine analogs, monoclonal antibodies, other emerging therapeutics CAR T-cell therapy. The NCCN Guidelines for the Prevention...
Abstract Background Refractory methicillin-resistant Staphylococcus aureus (MRSA) bacteremia continues to represent a challenge in clinical treatment. Telavancin, lipoglycopeptide with multiple mechanisms of action, has been proposed as treatment option these cases. Methods This was single-center, retrospective chart review adult inpatients refractory MRSA (defined > 72 hours following the start daptomycin or vancomycin) who were treated telavancin from December 2014 through March...
Abstract Objective: To better understand clinicians’ rationale for ordering testing C. difficile infection (CDI) patients receiving laxatives and the impact of implementation a clinical decision support (CDS) intervention. Design: A mixed-methods, case series was performed from March 2, 2017 to December 31, 2018. Setting: Yale New Haven Hospital, 1,541 bed tertiary academic medical center. Participants: Hospitalized ≥ 18 years old, clinicians who were alerted by CDS. Intervention: CDS...
Background: Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and infective endocarditis (IE) have become increasingly difficult to treat over the past decade, with suboptimal response rates of less than 50%. Although vancomycin daptomycin are standard therapeutic options, treatment failures either or both agents common. Telavancin is a lipoglycopeptide antibiotic activity against MRSA. In vitro, telavancin displays bactericidal has lower minimum inhibitory concentrations MRSA...
Empiric antifungal coverage is indicated in patients with graft-versus-host disease (GVHD) following a stem cell transplant (SCT) who are febrile and neutropenic for extended periods of time. hematologic malignancies have persistent fever neutropenia as well GVHD SCT. Although the prophylactic use antifungals cornerstone care such patients, selection particular at discretion clinician. We report patient case whose surveillance blood cultures obtained 14 days after switch from voriconazole to...
Abstract Background Neuraminidase inhibitors, including oseltamivir, are the treatment standard for influenza. Baloxavir, a novel antiviral, demonstrated comparable outcomes to oseltamivir in outpatients with Baloxavir was equally effective as retrospective study of hospitalized patients influenza at our institution. However, efficacy baloxavir immunocompromised is unclear. Methods We conducted cohort adult A who received from January 2019 April or 2018 2018. Demographic and clinical were...
Vancomycin is a glycopeptide antibiotic used in the treatment of gram‐positive infections including methicillin‐resistant Staphylococcus aureus (MRSA). The most common adverse reaction to vancomycin red man syndrome, which histaminergic causing rash on upper torso, neck, and face after rapid infusion drug. Less commonly, has been associated with thrombocytopenia. etiology believed be induction drug‐dependent antibodies, turn cause immune‐mediated destruction platelets. We describe...
Abstract Norovirus enteritis can cause intractable diarrhea in solid organ transplant (SOT) recipients, for which there are no established treatments. We reviewed medical records of 9 SOT recipients at our center who received orally administered human immunoglobulin norovirus enteritis, and it appeared to be an effective treatment modality.
ABSTRACT One hundred two stool samples were tested by both the rapid Triage Clostridium difficile Panel (Triage Panel) and cytotoxin cell culture assay. Five positive C. toxin A (Tox A) common antigen components of had titers ≥10,000. Twenty-three Tox negative but positive. Ten these 10 to 1,000, 13 negative. Bacterial isolates obtained from 8 specimens analyzed for B genes PCR, only contained toxigenic bacteria. Thus, majority nontoxigenic A-positive result indicated a sensitivity,...
Abstract During the COVID-19 pandemic, antimicrobial stewardship module in our electronic medical record was reconfigured for management of patients. This change allowed subspecialist providers to review charts quickly optimize potential therapy and during patient surge.