A5035181199- Antifungal resistance and susceptibility
- Neutropenia and Cancer Infections
- Fungal Infections and Studies
- Bacterial Identification and Susceptibility Testing
- Mycobacterium research and diagnosis
- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Infections and bacterial resistance
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotic Resistance in Bacteria
- Infectious Diseases and Mycology
- Infectious Diseases and Tuberculosis
- Clostridium difficile and Clostridium perfringens research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pneumonia and Respiratory Infections
- Oral health in cancer treatment
- Infective Endocarditis Diagnosis and Management
- Actinomycetales infections and treatment
- Tuberculosis Research and Epidemiology
- Microbial infections and disease research
- Diverticular Disease and Complications
- Diphtheria, Corynebacterium, and Tetanus
- Polyomavirus and related diseases
- Enterobacteriaceae and Cronobacter Research
- Appendicitis Diagnosis and Management
University of South Florida
2015-2025
Moffitt Cancer Center
2016-2025
Tallaght University Hospital
2023
Office of Infectious Diseases
2021
University of Pittsburgh Medical Center
2020-2021
Edward Via College of Osteopathic Medicine
2021
University of South Alabama Medical Center
2021
Case Western Reserve University
2021
Florida College
2006-2018
AdventHealth Tampa
2017
Infectious diseases are important causes of morbidity and mortality in patients with cancer. The NCCN Clinical Practice Guidelines Oncology (NCCN Guidelines) for Prevention Treatment Cancer-Related Infections characterize the major pathogens to which cancer susceptible, a focus on prevention, diagnosis, treatment common opportunistic infections. This portion guidelines highlights sections antifungal antiviral prophylaxis. Antifungal prophylaxis recommendations have expanded over past few...
Patients with cancer are at increased risk for developing infectious complications during the course of their disease and treatment. The following sections NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) Prevention Treatment Cancer-Related Infections provide an overview factors complications, recommendations categorization, strategies prevention infections high-risk patient populations cancer. Individualized evaluation incorporation preventative measures essential components...
The outcomes for 73 invasive fusariosis patients treated with voriconazole were investigated. Patients proven (n = 67) or probable 6) infections identified from the clinical database 39) and French National Reference Center Mycoses Antifungals 34). Investigator-determined success was a complete partial response. Survival determined day 1 of therapy to last known alive. 2 79 years old (median, 43 years), 66% male. Identified Fusarium species (62%) F. solani, moniliforme, proliferatum,...
Background: Breast prosthesis reconstruction continues to be the most common form of breast reconstruction, and infection exposure remain major concerns for patients surgeons. Methods: A retrospective review was performed who underwent attempted implant salvage between 2002 2008 by a single surgeon according protocol. Analyzed data include detailed patient demographics, clinical laboratory findings, outcomes. Results: Sixty were identified had been taken operating room secondary and/or...
Abstract Background Invasive fungal infections (IFI) carry a high mortality risk in hematologic malignancy; the majority being pulmonary infections. Diagnosis is based on consensus definitions of host factors, clinical features and mycologic evidence. In previous studies, increased associated with delays therapy failure neutrophil recovery; however, use salvage posaconazole may have improved outcomes. We sought to identify factors higher 90-day these patients. Methods Patients at an NCI...
Abstract Cryptococcus species, particularly C. gattii and neoformans , are opportunistic pathogens typically affecting immunocompromised individuals, although cases in immunocompetent patients increasingly recognized. We report the incidental discovery of cryptococcal lymphadenitis a hepatic artery lymph node during cancer staging. Differential diagnoses for periportal lymphadenopathy include both malignant infectious processes, with presence necrotizing granulomas narrowing differential...
Abstract This retrospective study presents an analysis of Hafnia alvei infections in 15 cancer patients at the H. Lee Moffitt Cancer Center from June 2013 to February 2020. All had underlying malignancies, primarily solid organ malignancies (73%). The mean patient age was 65.7 years, and average duration hospital stay 17.7 days. Infection cultures were predominantly monomicrobial (53%) obtained mainly urinary tract (33%). Co-isolates polymicrobial frequently included Klebsiella pneumoniae...
A risk mitigation strategy was implemented to determine if a higher prophylactic voriconazole dosage in patients with CYP2C19 rapid metabolizer neutropenic acute myeloid leukemia (AML) reduces the incidence of subtherapeutic trough concentrations. Patients AML ( n = 263) were preemptively genotyped for CYP2C19*2 , *3 and *17 alleles as part single‐center prospective, interventional, quality improvement study. metabolizers CYP2C19*1/*17 ) recommended receive interventional 300 mg twice daily,...
Abstract Background Posaconazole maintains broad antifungal activity and is employed for prevention treatment of invasive fungal infections in oncology patients. Older formulations required therapeutic drug monitoring, specific plasma levels have been recommended. This study evaluated factors associated with subtherapeutic concentrations the newer delayed-release tablet formulation. Methods In this retrospective, single-center cohort at a national comprehensive cancer center, all patients...
Tacrolimus is an immunosuppressive drug mainly used to lower the risk of transplant rejection in individuals who are post solid organ or hematopoietic transplantation. It a macrolide which reduces peptidyl-propyl isomerase activity and inhibits calcineurin, thus inhibiting T-lymphocyte signal transduction interleukin-2 (IL-2) transcription. has been associated with Posterior Reversible Encephalopathy Syndrome (PRES), disease sudden onset that can present as host different symptoms, depending...
The histories of 17 patients who had a cholecystectomy during pregnancy were reviewed. All operated upon for clinical recurrent biliary colic. Four aborted or premature labour. It appears that there is an increased risk fetal loss if performed pregnancy. Because this, it would appear reasonable to perform the operation only exigencies situation demand surgery be done. should borne in mind may also from colic treated symptomatically, particularly cholecystitis and jaundice complicate matters...
The introduction of antiretroviral therapy (ART) in 1995 had a dramatic impact on the morbidity and mortality HIV population, subsequently, natural history cancer has changed. purpose our study was to review prevalence AIDS-defining malignancies non-AIDS defining cancers (NADC), taking into consideration racial gender variations. After institutional board approval, conducted as retrospective chart 279 HIV-infected patients who were treated at Moffitt Cancer Center between January 1, 2000...