A5040758762- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Histone Deacetylase Inhibitors Research
- Retinoids in leukemia and cellular processes
- Neutropenia and Cancer Infections
- PARP inhibition in cancer therapy
- Protein Degradation and Inhibitors
- Cancer therapeutics and mechanisms
- Cancer-related Molecular Pathways
- DNA Repair Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Cancer-related gene regulation
- Cell death mechanisms and regulation
- Antifungal resistance and susceptibility
- RNA Interference and Gene Delivery
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Cancer Treatment and Pharmacology
- Lung Cancer Treatments and Mutations
- Fungal Infections and Studies
- Lymphoma Diagnosis and Treatment
Johns Hopkins University
2014-2024
Sidney Kimmel Comprehensive Cancer Center
2015-2024
Sidney Kimmel Cancer Center
2008-2023
Johns Hopkins Hospital
1989-2021
Johns Hopkins Medicine
1985-2021
Northwestern University
2009-2020
Klinik und Poliklinik für Kinder- und Jugendmedizin
2019
National Heart Lung and Blood Institute
2013-2016
National Institutes of Health
1993-2016
Georgia Regents Medical Center
2016
In early 1990 fluconazole was introduced as a prophylactic antifungal agent after bone marrow transplantation. During the same year Candida krusei emerged chief candida pathogen among patients with transplants.
Abstract Optimal reexpression of most genes silenced through promoter methylation requires the sequential application DNA methyltransferase inhibitors followed by histone deacetylase in tumor cell cultures. Patients with myelodysplastic syndrome or acute myeloid leukemia (AML) were treated inhibitor 5-azacitidine (aza-CR) sodium phenylbutyrate. Major responses associated cytogenetic complete response developed patients receiving prolonged dosing schedules aza-CR. Bisulfite sequencing p15...
We studied 25 patients with acute nonlymphocytic leukemia in second remission (20 patients) or third (5 whom autologous bone marrow transplantation was performed use of incubated ex vivo the alkylating agent 4-hydroperoxycyclophosphamide. Patients received intensive cytoreductive therapy busulfan and cyclophosphamide total body irradiation, followed by an infusion that had been collected remission, treated 4-hydroperoxycyclophosphamide, cryopreserved. Four died from bacterial fungal sepsis...
Patients with cancer are at increased risk for developing infectious complications during the course of their disease and treatment. The following sections NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) Prevention Treatment Cancer-Related Infections provide an overview factors complications, recommendations categorization, strategies prevention infections high-risk patient populations cancer. Individualized evaluation incorporation preventative measures essential components...
Our understanding of phenotypic and functional signatures CD8+ T cell dysfunction in acute myeloid leukemia (AML) is limited. Deciphering these deranged states how they are impacted by induction chemotherapy essential for incorporation novel immune-based strategies to restore maintain antileukemia immunity.We utilized high-dimensional immunophenotyping, gene expression, studies characterize peripheral blood bone marrow cells 72 AML patients at diagnosis after chemotherapy.Our data suggest...
Because the use of fluconazole prophylaxis had been associated with an increased rate Candida krusei infections at The John Hopkins Oncology Center, early empiric amphotericin B plus flucytosine were given to febrile neutropenic patients colonized by C. krusei. By this practice, proportion fungemias attributable was low (12.5%) in receiving over a 6-month interval. However, Torulopsis (Candida) glabrata assumed much higher (75%) among fluconazole. In vitro susceptibility testing combined...
We evaluated the effect of norfloxacin, 400 mg given orally every 12 hours, on prevention bacterial infections in 68 adult patients who had acute leukemia throughout prolonged courses granulocytopenia (median, 32 days). Gram-negative were documented 13 33 receiving placebo, but only 4 35 norfloxacin; no frequency gram-positive or fungal was noted. Norfloxacin administration resulted suppression gastrointestinal tract colonization by aerobic bacteria without development norfloxacin...
• We prospectively examined the eyes of 120 patients with leukemia. Only 38% had normal results examination. Leukemic infiltrates were present in 3% patients, other findings related to leukemia seen 39% and 20% unrelated abnormalities. Visual loss was at least 5% this study.
During a 2-year period, 15 of 110 patients (14%) admitted for intensive therapy acute leukemia associated with prolonged deep granulocytopenia developed documented invasive aspergillosis (IA). Antemortem diagnosis was accomplished in 14, and 13 (87%) survived the infection. Because high success rate, we reviewed courses to assess factors this favorable outcome. Eleven presented pulmonary IA; early symptoms occurred at mean 21.6 days (less than 100/muL) included refractory fever 14 signs or...
Abstract Purpose: Vascular endothelial growth factor (VEGF) promotes acute myelogenous leukemia (AML) cell and survival may contribute to drug resistance. bevacizumab, an anti-VEGF monoclonal antibody, exhibits clinical activity against diverse malignancies when administered with cytotoxic chemotherapy. We conducted a Phase II trial of bevacizumab after chemotherapy adults refractory or relapsed AML, using timed sequential therapy (TST) approach. Experimental Design: 10 mg/kg was on day 8...