A5014895157- Estrogen and related hormone effects
- Acute Myeloid Leukemia Research
- Mechanisms of cancer metastasis
- Neuroblastoma Research and Treatments
- Protein Degradation and Inhibitors
- Parasites and Host Interactions
- Research on Leishmaniasis Studies
- Glioma Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- HER2/EGFR in Cancer Research
- Energy Harvesting in Wireless Networks
- Wireless Power Transfer Systems
- RFID technology advancements
- Synthetic Organic Chemistry Methods
- Helminth infection and control
- Forensic Toxicology and Drug Analysis
- Cancer Treatment and Pharmacology
- Cannabis and Cannabinoid Research
- Cell death mechanisms and regulation
- Chronic Myeloid Leukemia Treatments
- Radiopharmaceutical Chemistry and Applications
- Neuroendocrine Tumor Research Advances
- Pharmacological Receptor Mechanisms and Effects
- Marine Toxins and Detection Methods
- Career Development and Diversity
Tennessee Technological University
2023-2024
Clemson University
2024
Indiana University Bloomington
2024
North Carolina State University
2024
University of Maryland, College Park
2024
The University of Texas at San Antonio
2021-2023
The University of Texas Health Science Center at San Antonio
2023
U-M Rogel Cancer Center
2004-2015
University of Maryland, Baltimore
2004-2015
Southwest Research Institute
2014-2015
Ebola virus causes sporadic outbreaks of lethal hemorrhagic fever in humans, but there is no currently approved therapy. Cells take up by macropinocytosis, followed trafficking through endosomal vesicles. However, few factors controlling movement are known. Here we find that entry into host cells requires the calcium channels called two-pore (TPCs). Disrupting TPC function gene knockout, small interfering RNAs, or small-molecule inhibitors halted and prevented infection. Tetrandrine, most...
Abstract Purpose: Vascular endothelial growth factor (VEGF) promotes acute myelogenous leukemia (AML) cell and survival may contribute to drug resistance. bevacizumab, an anti-VEGF monoclonal antibody, exhibits clinical activity against diverse malignancies when administered with cytotoxic chemotherapy. We conducted a Phase II trial of bevacizumab after chemotherapy adults refractory or relapsed AML, using timed sequential therapy (TST) approach. Experimental Design: 10 mg/kg was on day 8...
Human schistosomiasis is a neglected tropical disease caused by Schistosoma mansoni , S . haematobium and japonicum Praziquantel (PZQ) the method of choice for treatment. Due to constant selection pressure, there an urgent need new therapies schistosomiasis. Previous treatment included use oxamniquine (OXA), drug that activated schistosome sulfotransferase (SULT). Guided data from X-ray crystallography killing assays more than 350 OXA derivatives were designed, synthesized, tested. We able...
Abstract Background: Glioblastoma (GBM) is the most common and aggressive brain tumor, with a poor 5-year survival rate. Epidemiological studies suggest that estrogen receptor beta (ERb) may inhibit tumor growth, highlighting potential therapeutic role of ERb. However, lack potent, selective, brain-permeable ERb ligands has limited clinical application ERb-based therapies. We recently identified indanone tetralone-keto oximes as promising agonists. To further optimize these compounds, we...
A focused screening strategy identified thienopyrimidine 12 as a cannabinoid receptor type 2 agonist (hCB2) with moderate selectivity over the hCB1 receptor. This initial hit suffered from poor in vitro metabolic stability and high vivo clearance. Structure-activity relationships describe optimization modification to new more polar series of purine CB2 agonists. Examples this novel scaffold were found be highly potent fully efficacious agonists human excellent against CB1, often having no...
Abstract Glioblastoma (GBM) is the most prevalent and aggressive type of adult brain tumors with low 5-year overall survival rates. Epidemiologic data suggest that estrogen may decrease tumor growth, receptor beta (ERβ) has been demonstrated to exert antitumor functions in GBM. The lack potent, selective, permeable ERβ agonist promote its action limiting therapeutic promise ERβ. In this study, we discovered Indanone tetralone-keto or hydroxyl oximes are a new class agonists. Because high...
Harmful algal blooms (HABs) of Microcystis aeruginosa can pose severe public health hazards due to potent toxins released by this cyanobacterial species. To elucidate the biological mechanism M. PCC7806 and identify best treatment reduce toxin production, 18 homoserine lactones (HSLs) different chemical structures were synthesized used at concentration 50 mg/L applied early log phase. The effectiveness was based on physiological responses after cells reached stationary stage. Results...
CD4 count ≤200×106 cells/L has been identified as a predictor of short survival in HIV-associated acute myeloid leukemia (HIV-AML), but karyotype, which is the best AML, not evaluated HIV-AML patients. A retrospective cohort 31 patients was created from 9 local cases and 22 published cases. karyotypes were heterogeneous similar distribution to those HIV-negative AML. Among intensively treated patients, most achieved complete remission, succumbed infectious complications, mostly...
[formula: see text] Intramolecular Friedel-Crafts cyclization of 2-O-benzyl ethers at a model pyranose acetal is activated by incorporation trimethylsilyl group, albeit via unexpected, presumably steric means.
Abstract In recent years, research has associated grade point average (GPA) with a variety of student outcomes during their undergraduate careers. The studies link higher GPAs to students being more likely graduate in major, while lower have been linked switching majors or leaving the institution. Further research, which focuses on how Black female and male remain successful different engineering degrees, is necessary identify underlying elements contributing entrance into exit from...
Abstract Our transformative mixed-methods project, funded by the Division of Engineering Education and Centers, responds to calls for more cross-institutional qualitative longitudinal studies minorities in engineering education. project builds on prior work that demonstrated impacts gender race academic trajectories Electrical, Computer, Mechanical (EE, CpE, ME, respectively) answer following questions: 1. Why do Black men women choose persist in, or leave, EE, ME? 2. What are 3. In what...
Human schistosomiasis, one of the most important neglected tropical diseases caused by parasitic worms genus Schistosoma. It is accompanied severe clinical symptoms as well socioeconomic problems, and more than 200,000 deaths per year. According to WHO, some 229 million people in 78 countries are affected. Although disease transmission common subtropical areas, a potential shift schistosomiasis into new habitat like south Europe anticipated due climate change. No vaccine available, only drug...
With the growing research into Through Soil wireless power transfer systems, supply design is necessary for determining a suitable topology capable of supplying high current density. A modified Marx inverter chosen to complete this task due extremely voltages produced. The presented analysis shows that TTS system performance metrics greatly improve with increased density and operating frequency. Finally, used operate its assessed.
<p>Supplementary Fig.S1 shows scheme for synthesis of ER beta agonist CIDD-0149897</p>
<p>Supplementary Fig.S1 shows scheme for synthesis of ER beta agonist CIDD-0149897</p>
<p>Supplementary Fig.S2 shows data specificity of CIDD-0149897 using ER beta KO cells.</p>
<p>Supplementary Fig.S3 shows efficacy of CIDD-0149897 combination therapy.</p>
<div>Abstract<p>Glioblastoma (GBM) is the most prevalent and aggressive type of adult brain tumors with low 5-year overall survival rates. Epidemiologic data suggest that estrogen may decrease tumor growth, receptor beta (ERβ) has been demonstrated to exert anti-tumor functions in GBM. The lack potent, selective permeable ERβ agonist promote its action limiting therapeutic promise ERβ. In this study, we discovered Indanone tetralone-keto or hydroxyl oximes are a new class ER...
<p>Supplementary Fig.S3 shows efficacy of CIDD-0149897 combination therapy.</p>