Jonathan M. Gerber
A5087346651- Acute Myeloid Leukemia Research
- COVID-19 Clinical Research Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Chronic Myeloid Leukemia Treatments
- Long-Term Effects of COVID-19
- Histone Deacetylase Inhibitors Research
- Cancer Genomics and Diagnostics
- Connexins and lens biology
- COVID-19 Impact on Reproduction
- Chronic Lymphocytic Leukemia Research
- Retinoids in leukemia and cellular processes
- Urological Disorders and Treatments
- Epigenetics and DNA Methylation
- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Immune cells in cancer
- Stress Responses and Cortisol
- Sperm and Testicular Function
- Economic and Financial Impacts of Cancer
- Blood groups and transfusion
- Eosinophilic Disorders and Syndromes
ZHAW Zurich University of Applied Sciences
2025
University of Massachusetts Chan Medical School
2019-2024
NYU Langone Health
2024
UMass Memorial Medical Center
2020-2024
UMass Memorial Health Care
2019-2024
New York University
2024
University of California, San Diego
2021
Levine Cancer Institute
2013-2020
University of Veterinary Medicine Hannover, Foundation
2013-2020
Carolinas Healthcare System
2014-2017
Michael C. Haffner 1 , Alcides Chaux 2 Alan K. Meeker 1,2,3 David M. Esopi Jonathan Gerber 4 Laxmi G. Pellakuru Antoun Toubaji Pedram Argani 1,2 Christine Iacobuzio-Donahue William Nelson George J. Netto Angelo De Marzo Srinivasan Yegnasubramanian Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA Department of Pathology, 3 Brady Urological Institute, Medicine, Division Hematology, School Received: September 1, 2011; Accepted: Published: 2,...
Polyclonal convalescent plasma may be obtained from donors who have recovered coronavirus disease 2019 (Covid-19). The efficacy of this in preventing serious complications outpatients with recent-onset Covid-19 is uncertain.
Motor axons regenerating after transection of mixed nerve preferentially reinnervate distal muscle branches, a process termed preferential motor reinnervation (PMR). axon collaterals appear to enter both cutaneous and Schwann cell tubes on random basis. Double-labeling studies suggest that PMR is generated by pruning from pathways while maintaining those in (the "pruning hypothesis"). If all projecting are saved, then stimulation regenerative sprouting should increase specificity increasing...
Significance Mechanisms that control physiologic hematopoietic stem-cell (HSC) self-renewal remain largely unknown. Inhibition of retinoic acid (RA) signaling in HSCs maintained their primitive phenotype and function, promoted self-renewal. Moreover, bone marrow stroma’s expression the cytochrome P450 retinoid-inactivating enzyme, CYP26, allowed HSC by maintaining an environment low retinoids. Thus, appear to be intrinsically programmed undergo RA-mediated differentiation unless prevented...
The ongoing evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants severely limits available effective monoclonal antibody therapies. Effective drugs are also supply limited. COVID-19 convalescent plasma (CCP) qualified for high levels effectively reduces immunocompetent outpatient hospitalization. Food and Drug Administration currently allows CCP the immunosuppressed. Viral-specific in can range 10- to 100-fold between donors, unlike uniform viral-specific...
Cytokines and chemokines play a critical role in the response to infection vaccination. We aimed assess longitudinal association of COVID-19 vaccination with cytokine chemokine concentrations trajectories among people SARS-CoV-2 infection. In this longitudinal, prospective cohort study, blood samples were used from participants enrolled multi-centre randomised trial assessing efficacy convalescent plasma therapy for ambulatory COVID-19. The was conducted 23 outpatient sites USA. (aged ≥18...
// Jonathan M. Gerber 1,* , Jessica L. Gucwa 2,* David Esopi 2 Meltem Gurel Michael C. Haffner Milada Vala William G. Nelson Richard J. Jones and Srinivasan Yegnasubramanian 1 Division of Hematology, Department Medicine, Johns Hopkins University School Baltimore, MD The Sidney Kimmel Comprehensive Cancer Center, University, MD, USA * These authors contributed equally to this work. Correspondence: Yegnasubramanian, email: Keywords : chronic myeloid leukemia, CML, leukemic stem cell, LSC,...
Abstract Background The efficacy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) convalescent plasma (CCP) for preventing infection in exposed, uninfected individuals is unknown. CCP might prevent when administered before symptoms or laboratory evidence infection. Methods This double-blinded, phase randomized, controlled trial (RCT) compared the and safety prophylactic high titer (≥1:320 by Euroimmun ELISA) with standard plasma. Asymptomatic participants aged ≥18 years close...
Summary Recursive partitioning of healthy consortia led to the development Clonal Hematopoiesis Risk Score (CHRS) for clonal haematopoiesis (CH); however, in practical setting, most cases CH are diagnosed after patients present with cytopenias or related symptoms. To address this real‐world population, we characterize clinical trajectories 94 and distinguish harbouring canonical DNMT3A/TET2/ASXL1 mutations alone (‘sole DTA’) versus all other groups (‘non‐sole DTA’). TET2 , rather than DNMT3A...
Although tyrosine kinase inhibitors have redefined the care of chronic myeloid leukemia (CML), these agents not proved curative, likely due to resistance stem cells (LSC). While a number potential therapeutic targets emerged in CML, their expression LSC remains largely unknown. We therefore isolated subsets CD34(+) stem/progenitor from normal donors and patients with phase or blast crisis CML. These cell were then characterized based on ability engraft immunodeficient mice candidate targets....
Leucine-rich α2 glycoprotein (LRG1), a serum protein produced by hepatocytes, has been implicated in angiogenesis and tumor promotion. Our laboratory previously reported the expression of LRG1 murine myeloid cell lines undergoing neutrophilic granulocyte differentiation. However, presence primary human neutrophils role for regulation hematopoiesis have not described. Here we show that is packaged into granule compartment secreted upon neutrophil activation to modulate microenvironment. Using...
ABSTRACT BACKGROUND The efficacy of polyclonal high titer convalescent plasma to prevent serious complications COVID-19 in outpatients with recent onset illness is uncertain. METHODS This multicenter, double-blind randomized controlled trial compared the and safety SARS-CoV-2 placebo control symptomatic adults ≥18 years positive for regardless risk factors disease progression or vaccine status. Participants symptom within 8 days were enrolled, then transfused subsequent day. measured primary...
Approximately 20% of individuals infected with SARS-CoV-2 experienced long-term health effects, as defined PCC. However, it is unknown if there are any early biomarkers associated PCC or whether intervention treatments may decrease the risk In a secondary analysis randomized clinical trial, this study demonstrates that among outpatients SARS-CoV-2, increased IL-6 at time infection odds addition, treated early, within 5 days symptom onset, COVID-19 convalescent plasma, was trend for decreased...
aberrations constitute the highest risk subset of myelodysplastic neoplasms (MDS) and acute myeloid leukemia (AML). The International Consensus Classification questions blast threshold between MDS AML. In this study, we assess distinction AML for 76 patients with
<title>Abstract</title> The ability to understand and process websites is crucial across various domains. It lays the foundation for machine understanding of websites. Specifically, website embedding proves invaluable when monitoring local government within context digital transformation. In this paper, we present a comparison different state-of-the-art methods their capability creating reasonable our specific task. models consist visual, mixed, textual-based methods. We compare with...
There is a high risk of voriconazole failure in those with subtherapeutic drug concentrations, which more common CYP 2C19 (cytochrome P450 2C19) rapid/ultrarapid metabolizers ( RMs / UM s). We evaluated genotype‐guided dosing on concentrations and clinical outcomes adult allogeneic hematopoietic cell transplant recipients. Poor PM s), intermediate IM normal NM s) received 200 mg twice daily; s 300 daily. Steady‐state trough were obtained after 5 days, targeting 1.0–5.5 mg/L. Of 89 evaluable...
Convalescent plasma, collected from donors who have recovered a pathogen of interest, has been used to treat infectious diseases, particularly in times outbreak, when alternative therapies were unavailable. The COVID-19 pandemic revived interest the use convalescent plasma. Large observational studies and clinical trials that executed during provided insight into how whereby high levels antibodies against administration early within time course disease are critical for optimal therapeutic...
BACKGROUND. COVID-19 convalescent plasma (CCP) virus-specific antibody levels that translate into recipient posttransfusion sufficient to prevent disease progression are not defined.
Coat color dilution turns black coat to blue and red cream is a characteristic in many mammalian species. Matings among Netherland Dwarf, Loh, Lionhead Dwarf rabbits over two generations gave evidence for monogenic autosomal recessive inheritance of colour dilution. Histological analyses showed non-uniformly distributed, large, agglomerating melanin granules the hair bulbs diluted rabbits. We sequenced cDNA MLPH dilute one rabbit polymorphism detection. In both rabbits, skipping exons 3 4...