A5018408679- Antibiotic Use and Resistance
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Antimicrobial Resistance in Staphylococcus
- Patient Satisfaction in Healthcare
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- COVID-19 Impact on Reproduction
- Clostridium difficile and Clostridium perfringens research
- Long-Term Effects of COVID-19
- Antibiotics Pharmacokinetics and Efficacy
- Streptococcal Infections and Treatments
- Mycobacterium research and diagnosis
- Drug-Induced Adverse Reactions
- Antibiotic Resistance in Bacteria
- Intramuscular injections and effects
- Respiratory and Cough-Related Research
- Pharmaceutical Practices and Patient Outcomes
- Blood groups and transfusion
- Urinary Tract Infections Management
- Nosocomial Infections in ICU
- Aortic Thrombus and Embolism
- Dermatological and COVID-19 studies
- Gastrointestinal motility and disorders
- Infectious Disease Case Reports and Treatments
Vassar Brothers Medical Center
2021-2025
Piedmont Athens Regional
2024
Covance (United States)
2022-2023
Lindsay Unified School District
2022
New York Proton Center
2015-2022
Communities In Schools of Orange County
2022
University of Richmond
2022
Oregon Medical Research Center
2022
Ann Arbor Center for Independent Living
2022
Poughkeepsie Public Library District
2019-2021
Polyclonal convalescent plasma may be obtained from donors who have recovered coronavirus disease 2019 (Covid-19). The efficacy of this in preventing serious complications outpatients with recent-onset Covid-19 is uncertain.
Patients hospitalized with hematologic malignancy are particularly vulnerable to infection. The impact of reported beta-lactam (BL) allergy in this population remains unknown.This was a retrospective cohort study adult inpatients admitted at 2 tertiary care hospitals from 2010 through 2015. primary outcome hospital length stay (LOS) after administration the first antibiotic. Secondary outcomes included readmission, mortality, complications, charges, and antibiotic usage. Our goal define...
Cytokines and chemokines play a critical role in the response to infection vaccination. We aimed assess longitudinal association of COVID-19 vaccination with cytokine chemokine concentrations trajectories among people SARS-CoV-2 infection. In this longitudinal, prospective cohort study, blood samples were used from participants enrolled multi-centre randomised trial assessing efficacy convalescent plasma therapy for ambulatory COVID-19. The was conducted 23 outpatient sites USA. (aged ≥18...
Abstract Background The efficacy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) convalescent plasma (CCP) for preventing infection in exposed, uninfected individuals is unknown. CCP might prevent when administered before symptoms or laboratory evidence infection. Methods This double-blinded, phase randomized, controlled trial (RCT) compared the and safety prophylactic high titer (≥1:320 by Euroimmun ELISA) with standard plasma. Asymptomatic participants aged ≥18 years close...
We conducted a retrospective study of the appropriateness antimicrobial agents prescribed on discharge from an acute care hospital. Seventy percent antibiotics were inappropriate in antibiotic drug choice, dose, or duration. Our findings suggest there is significant need for stewardship at transitions care. Infect Control Hosp Epidemiol 2017;38:353–355
ABSTRACT BACKGROUND The efficacy of polyclonal high titer convalescent plasma to prevent serious complications COVID-19 in outpatients with recent onset illness is uncertain. METHODS This multicenter, double-blind randomized controlled trial compared the and safety SARS-CoV-2 placebo control symptomatic adults ≥18 years positive for regardless risk factors disease progression or vaccine status. Participants symptom within 8 days were enrolled, then transfused subsequent day. measured primary...
Background. The duration of colonization and factors associated with clearance methicillin-resistant Staphylococcus aureus (MRSA) after community-onset MRSA skin soft-tissue infection (SSTI) remain unclear. Methods. We conducted a prospective cohort study patients acute SSTI presenting to 5 adult pediatric academic hospitals from 1 January 2010 through 31 December 2012. Index household members performed self-sampling for every 2 weeks 6 months. Clearance was defined as negative surveillance...
BACKGROUND. COVID-19 convalescent plasma (CCP) virus-specific antibody levels that translate into recipient posttransfusion sufficient to prevent disease progression are not defined.
Inappropriate antibiotic prescribing is common in primary care (PC), particularly for respiratory tract diagnoses (RTDs). However, the optimal approach improving remains unknown.We conducted a stepped-wedge study PC practices within health system to assess impact of provider-targeted intervention on RTDs. RTDs were grouped into tiers based appropriateness prescribing: tier 1 (almost always indicated), 2 (may be and 3 (rarely indicated). Providers received education appropriate RTD followed...
Abstract Background COVID‐19 convalescent plasma (CCP) is an important therapeutic option for outpatients at high risk of hospitalization from SARS‐CoV‐2 infection. We assessed the safety outpatient CCP transfusions administered during clinical trials. Study Design and Methods analyzed data pertaining to transfusion‐related reactions two randomized controlled trials in U.S. that evaluated efficacy versus control various ambulatory settings. Multivariable logistic regression was used assess...
ABSTRACT Early COVID-19 convalescent plasma (CCP) transfusion to outpatients with decreases progression hospitalization, but the mechanism of how CCP reduces severity is unknown. Among 882 participants transfused or control in a randomized controlled trial, 21 cytokines and chemokines were measured using electrochemiluminescence assays. Wilcoxon rank sum tests used evaluate difference between early (transfused within 5 days symptom onset) vs late 6–9 after at each visit. Linear mixed-effect...
OBJECTIVE To determine the impact of total household decolonization with intranasal mupirocin and chlorhexidine gluconate body wash on recurrent methicillin-resistant Staphylococcus aureus (MRSA) infection among subjects MRSA skin soft-tissue infection. DESIGN Three-arm nonmasked randomized controlled trial. SETTING Five academic medical centers in Southeastern Pennsylvania. PARTICIPANTS Adults children presenting to ambulatory care settings community-onset (ie, index cases) their members....
Patients with community-onset (CO) methicillin-resistant
Abstract Objective: To determine metrics and provider characteristics associated with inappropriate antibiotic prescribing for respiratory tract diagnoses (RTDs). Design: Retrospective cohort study. Setting: Primary care practices in a university health system. Participants: Patients seen by an attending physician or advanced practice (APP) at their primary office visit International Classification of Disease, Tenth Revision, Clinical Modification (ICD-10-CM)–coded RTDs. Methods: Medical...
OBJECTIVE To identify risk factors for recurrent methicillin-resistant Staphylococcus aureus (MRSA) colonization. DESIGN Prospective cohort study conducted from January 1, 2010, through December 31, 2012. SETTING Five adult and pediatric academic medical centers. PARTICIPANTS Subjects (ie, index cases) who presented with acute community-onset MRSA skin soft-tissue infection. METHODS Index cases all household members performed self-sampling colonization every 2 weeks 6 months. Clearance of...
ABSTRACT Two screening methods to detect staphylococcal colonization in humans were compared. Direct plating CHROMagar (BD Diagnostics) was compared a broth preenrichment followed by Baird-Parker agar. The broth-enrichment method comparable for methicillin-resistant Staphylococcus aureas (MRSA) detection, but the enrichment optimum recovery of coagulase-positive spp.
ABSTRACT BACKGROUND The efficacy of SARS-CoV-2 convalescent plasma (CCP) for preventing infection in exposed, uninfected individuals is unknown. We hypothesized that CCP might prevent when administered before symptoms or laboratory evidence infection. METHODS This double-blinded, phase 2 randomized, controlled trial (RCT) compared the and safety prophylactic high titer (≥1:320) with standard plasma. Asymptomatic participants aged ≥18 years close contact exposure to a person confirmed...
Automatic stop orders (ASOs) for antimicrobials have been recommended as a component of antimicrobial stewardship programs, but may result in unintentional treatment interruption due to failure providers re-order an medication. We examined the impact multifaceted intervention designed reduce potential harms interrupting ASOs.An was implemented that included pharmacist review expiring well provider education encourage use long-term order set commonly used prophylactic antimicrobials....
To determine antibiotic prescribing appropriateness for respiratory tract diagnoses (RTD) by season.Retrospective cohort study.Primary care practices in a university health system.Patients who were seen at an office visit with diagnostic code RTD.Office visits the entire categorized based on ICD-10 codes likelihood that was indicated (tier 1: always indicated; tier 2: sometimes 3: rarely indicated). Medical records reviewed 1,200 randomly selected to appropriateness. Based this reference...
Below we highlight a rare case of anti-neutrophil cytoplasmic antibody (ANCA)-negative vasculitis, unique in its own right, as the diagnosis was hard to make and respiratory decline rapid, with patient going from 23% fraction inspired oxygen (FiO2) on admission 100% FiO2 within four days for what initially presumed be community-acquired pneumonia. Precise data incidence or prevalence ANCA-associated vasculitis are lacking. However, 20-year population-based study United States found that, 58...
Myocardial infarction (MI) remains a common cause of morbidity and mortality. Although many well-known risk factors exist, the association between inherited thrombophilia disorders acute MI is not well described. Here, we present case 75-year-old male with known 4G/4G PAI-1 polymorphism, methylenetetrahydrofolate reductase (MTHFR) mutation, peripheral artery disease (PAD) post stent placement who presented cardiogenic shock in setting no prior significant cardiac history.
May-Thurner syndrome (MTS) can lead to deep venous thrombosis (DVT) in the left lower extremity, and it is often triggered by factors such as surgery or pregnancy. We present a rare case where risk factor for thromboembolism MTS complication from COVID-19 vaccination. A 44-year-old female who presented with fatigue, fever, myalgia had developed of Johnson & vaccine. Diagnostic criteria vaccine-induced immune thrombotic thrombocytopenia (VITT) should be considered cases that include symptoms...
Cryoglobulinemia may result in small-to-medium vessel vasculitis. Central nervous system (CNS) involvement is rare, and presentation range from stroke/transient ischemic attack, reversible neurological deficits, to encephalopathic syndromes. This a rare case discussing cryoglobulinemia with CNS involvement. A 56-year-old female history of was found unresponsive verbal physical stimuli. She admitted the intensive care unit. CT head without contrast showed diffuse cerebral edema mass effect...