A5030639018- Multiple Myeloma Research and Treatments
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Genomics and Phylogenetic Studies
- Peptidase Inhibition and Analysis
- Mesenchymal stem cell research
- Protein Degradation and Inhibitors
- Acute Myeloid Leukemia Research
- HIV/AIDS Research and Interventions
- Sepsis Diagnosis and Treatment
- Advanced biosensing and bioanalysis techniques
- HIV Research and Treatment
- Air Quality and Health Impacts
- HIV/AIDS drug development and treatment
- Health Literacy and Information Accessibility
- Chronic Myeloid Leukemia Treatments
- Microbial Community Ecology and Physiology
- Streptococcal Infections and Treatments
- Cancer Treatment and Pharmacology
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Mobile Health and mHealth Applications
- Plant-Microbe Interactions and Immunity
- Synthesis and biological activity
- Natural Compounds in Disease Treatment
Capital Medical University
2019-2025
Eye & ENT Hospital of Fudan University
2024-2025
Beijing Friendship Hospital
2019-2025
University of Pennsylvania
2015-2024
Zhejiang University
2013-2024
Weifang People's Hospital
2017-2024
Hunan University
2007-2024
Roche (China)
2020-2024
Xi'an University of Architecture and Technology
2024
Beijing Center for Disease Prevention and Control
2017-2024
Objective: Treatment of coexisting medical comorbidities may reduce the risk adverse outcomes among patients with bipolar disorder. We determined prevalence general conditions in a population‐based sample diagnosed disorder Veterans Administration (VA). Methods: conducted cross‐sectional study (n = 4310) fiscal year 2001 receiving care at VA facilities located within mid‐Atlantic region. General were assessed using ICD‐9 codes, and we compared each condition our national data on patient...
Mechanisms associated with the progression of simple steatosis to non-alcoholic fatty liver disease (NAFLD) remain undefined. Regulatory T cells (T(regs)) play a critical role in regulating inflammatory processes steatohepatitis (NASH) and because helper type 17 (Th17) functionally oppose T(reg)-mediated responses, this study focused on characterizing Th17 using NAFLD mouse model. C57BL/6 mice were fed either normal diet (ND) or high fat (HF) for 8 weeks. Mice HF group had significantly...
IL-17 is one of the most potent and actively investigated proinflammatory cytokines. In this study, we examined effect on mesenchymal stem cells (MSCs) under influence inflammatory Ironically, dramatically enhanced immunosuppressive MSCs induced by IFNγ TNFα, revealing a novel role in immunosuppression. Interestingly, found that action was dependent promoted expression key immune suppressive molecule, inducible nitric oxide synthase (iNOS), MSCs. concanavalin A (ConA)-induced hepatitis mouse...
Mesenchymal stem cells (MSCs) possess potent immunosuppression capacity and could exert strong therapeutic effects in many diseases, especially inflammatory disorders, animal models clinical settings. Although cytokines are critical inducing the immune modulatory properties of MSCs, detailed molecular mechanisms yet to be fully understood. TGF-β is a well-known anti-inflammatory cytokine exists various processes; therefore, we investigated whether it synergize with MSCs suppressing...
Chemotherapy-induced peripheral neuropathy (CIPN) seriously affects the quality of life patients with multiple myeloma (MM) as well response rate to chemotherapy. Acupuncture has a potential role in treatment CIPN, but at present there have been no randomized clinical research studies analyze effectiveness acupuncture for particularly MM patients. The (104 individuals) who met inclusion criteria were randomly assigned into solely methylcobalamin therapy group (500 μg intramuscular injections...
Abstract Background This study investigated the therapeutic effects of MSC-derived exosomes (MSC-Exos) on erectile function in a rat model cavernous nerve injury (CNI). Methods MSCs were isolated from bone marrow and supernatants by ultracentrifugation. The tissue explant adherent method was used to isolate culture corpus cavernosum smooth muscle cells (CCSMCs). CCSMCs identified flow cytometry, vitro differentiation or immunofluorescence staining. Thirty-two 10-week-old male Sprague Dawley...
A high-fat diet-induced C57BL/6N mouse model of non-alcoholic fatty liver disease (NAFLD) was established. The effect and mechanism Raw Bowl Tea polyphenols (RBTP) on preventing NAFLD via regulating intestinal function were observed. serum, liver, epididymis, small intestine tissues, feces mice examined by biochemical molecular biological methods, the composition RBTP analyzed HPLC assay. results showed that could effectively reduce body weight, index mice. serum effects were: (1) decreases...
Abstract Objective The utilization of joint arthroplasty for knee or hip osteoarthritis varies markedly by patient race/ethnicity. Because concerns about surgical risk, black patients are less willing to consider this treatment. There few published race/ethnicity‐specific data on outcomes. present study was undertaken examine racial/ethnic differences in mortality and morbidity following elective arthroplasty. Methods Using information from the Veterans Administration National Surgical...
Many bacterial pathogens produce extracellular proteases that degrade the matrix of host and therefore are involved in disease pathogenesis. Dichelobacter nodosus is causative agent ovine footrot, a highly contagious characterized by separation hoof from underlying tissue. D. secretes three subtilisin-like whose analysis forms basis diagnostic tests differentiate between virulent benign strains have been postulated to play role virulence. We constructed protease mutants nodosus; their sheep...
MSCs possess potent immunosuppressive capacity. We have reported that mouse inhibit T cell proliferation and function via nitric oxide. This immune regulatory capacity of is induced by the inflammatory cytokines IFNγ together with either TNFα or IL-1β. effect on extraordinary; logarithmic increases in expression iNOS chemokines are often observed. To investigate molecular mechanisms underlying this robust cytokines, we examined microRNAs before after cytokine treatment. found miR-155 most...
Background: Vascular risk factors are increasingly recognized as risks for Alzheimer’s disease (AD) and early conversion from mild cognitive impairment (MCI) to dementia. While neuroimaging research in AD has focused on brain atrophy, metabolic function, or amyloid deposition, little attent ion been paid the effect of cerebrovascular decline. Objective: To investigate correlation atrophy white matter lesions with decline AD, MCI, control subjects. Methods: Patients healthy subjects were...
Adherence to antiretroviral therapy is critical successful treatment of human immunodeficiency virus (HIV). Few interventions have been demonstrated improve both adherence and virologic outcomes. We sought determine whether an intervention derived from problem solving theory, Managed Problem Solving (MAPS), would outcomes.We conducted a randomized investigator blind trial MAPS compared with usual care in HIV-1 infected individuals at 3 HIV clinics Philadelphia, Pennsylvania. Eligible...
Periplaneta americana is a common traditional Chinese medicinal material which has been used to treat arthritis, fever, aches, pains, and inflammation of the extremities for several hundred years. However, little scientific data exists in literature support its use. The purpose this study was evaluate antipyretic, anti-inflammatory analgesic activities extract (PAE) explore underlying mechanism. were evaluated by LPS-induced carrageenan-induced paw edema, abdominal writhing, hot plate...
Some solid tumors are characterized by extracellular matrix (ECM) remodeling and stiffening, which is related to tumor progression aggression.However, the relationship between ECM stiffness colorectal cancer (CRC) remains unclear.In this study, we investigated relevance of clinicopathologic features using human CRC tissue microarrays.The results demonstrate that expression components in tissues closely correlated with poor prognosis, indicates may be associated development.We further studied...
Clostridium perfringens causes a range of diseases in animals and humans including necrotic enteritis chickens food poisoning gas gangrene humans. Necrotic is concern commercial chicken production due to the cost implementation infection control measures productivity losses. This study has focused on genomic analysis chicken-derived C. isolates, from around world different years. The genomes were sequenced compared with 20 available public databases, which diverse collection isolates...
BEAS-2B was originally established as an immortalized but non-tumorigenic epithelial cell line from human bronchial epithelium. Because of general recognition for its origin, the has been widely used in vitro model a large variety studies associated with respiratory diseases including lung carcinogenesis. However, very few have discussed non-epithelial features cells, especially mesenchymal stem cells (MSCs), which represent group fibroblast-like limited self-renewal and differentiation...
Erectile dysfunction (ED) is an important kind of postoperative complication pelvic surgery that affects patients' quality life. Transplantation mesenchymal stem cells (MSC) has been found to alleviate ED caused by cavernous nerve injury (CNI) in rats. However, little known about whether induced pluripotent cell-derived (iMSC) have a therapeutic effect on CNI ED. We established model rats and evaluated the iMSC it. Methods: Eight-week-old male Sprague-Dawley were assigned four groups...
Background: The controlling nutritional status (CONUT) score and the prognostic index (PNI) were designed as indicators of patients’ immune-nutritional status. This study aimed to investigate impact CONUT PNI scores on long-term recurrent ischemic stroke (RIS) adverse outcomes for adults with acute (AIS). Methods: retrospective enrolled 991 AIS patients. Multivariable Cox regression models used assess relationships malnutritional indices RIS major cardiovascular events (MACEs). Results:...
The final enzymatic step required for collagen cross-linking is the extracellular oxidative deamination of peptidyl-lysine and -hydroxylysine residues by lysyl oxidase. A cross-linked collagenous matrix bone formation. goals this study were to compare transforming growth factor (TGF)-beta 1 regulation oxidase enzyme activity steady state mRNA levels changes in COL1A1 MC3T3-E1 osteoblastic cells. TGF-beta increased a dose- time-dependent manner. increase was transient, peaking at 12 h 8.8...
The Think Health! study evaluated a behavioral weight loss program adapted from the Diabetes Prevention Program (DPP) lifestyle intervention to assist primary care providers (PCPs) and auxiliary staff acting as coaches (LCs) in offering counseling their patients. In randomized trial conducted at five clinical sites, participants were randomly assigned 1:1 ratio within each site either “Basic Plus” ( n = 137), which offered PCP every 4 months plus monthly LC visits during first year of...
The rare wild species of snow lotus Saussurea involucrata is a commonly used medicinal herb with great pharmacological value for human health, resulting from its uniquely high level phenylpropanoid compound production. To gain information on the phenylpropanid biosynthetic pathway genes in this critically important plant, global transcriptome sequencing was performed. It revealed that were well represented S. involucrata. In addition, we introduced two key inducing transcription factors...
Proanthocyanidins (PAs) are the second most abundant plant phenolic natural products. PA biosynthesis is regulated by well-documented MYB/bHLH/WD40 (MBW) complex, but how this complex itself remains ill defined. Here, in situ hybridization and β-glucuronidase staining show that APETALA2 (AP2), a well-defined regulator of flower seed development, strongly expressed coat endothelium, where PAs accumulate. AP2 negatively regulates content expression levels key pathway genes. activates MYBL2...