A5091290338- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- Acute Myeloid Leukemia Research
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Cancer Cells and Metastasis
- Neonatal Respiratory Health Research
- Bone Metabolism and Diseases
- Systemic Lupus Erythematosus Research
- Renal Diseases and Glomerulopathies
- Rheumatoid Arthritis Research and Therapies
- Circular RNAs in diseases
- Chronic Lymphocytic Leukemia Research
- Ionic liquids properties and applications
- Neuroscience of respiration and sleep
- Complement system in diseases
- Gut microbiota and health
- CRISPR and Genetic Engineering
- RNA and protein synthesis mechanisms
- Chemical and Physical Properties in Aqueous Solutions
- Cancer-related gene regulation
- DNA Repair Mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
Ruijin Hospital
2025
Shanghai Jiao Tong University
2014-2025
Jiangnan University
2025
Chengdu Military General Hospital
2014-2025
Kunming Institute of Zoology
2016-2024
Chinese Academy of Sciences
2014-2024
University of California, Irvine
2024
Chongqing Medical University
2008-2024
Children's Hospital of Chongqing Medical University
2015-2024
Shenzhen Children's Hospital
2024
Triple-negative breast cancer (TNBC) exhibits poor prognosis, with high metastasis and low survival. Long non-coding RNAs (lncRNAs) play critical roles in tumor progression. Here, we identified lncRNA MIR100HG as a pro-oncogene for TNBC Knockdown of decreased cell proliferation induced arrest the G1 phase, whereas overexpression significantly increased proliferation. Furthermore, regulated p27 gene to control cycle, subsequently impacted progression TNBC. In analyzing its underlying...
IL-17 is one of the most potent and actively investigated proinflammatory cytokines. In this study, we examined effect on mesenchymal stem cells (MSCs) under influence inflammatory Ironically, dramatically enhanced immunosuppressive MSCs induced by IFNγ TNFα, revealing a novel role in immunosuppression. Interestingly, found that action was dependent promoted expression key immune suppressive molecule, inducible nitric oxide synthase (iNOS), MSCs. concanavalin A (ConA)-induced hepatitis mouse...
Increasing evidence shows that long noncoding RNAs (lncRNAs) have important roles in the regulation of multiple cellular processes, including cell division, growth, and apoptosis, as well cancer metastasis neurological disease progression; however, mechanism how lncRNAs regulate these processes is not established. In this study, we demonstrated downregulating expression lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) breast cells inhibited growth induced apoptosis. addition,...
Significance Triple-negative breast cancer (TNBC) is responsible for significant mortality among subtypes, with its treatment largely unsuccessful due to ineffective targeted therapies. Our bioinformatics analysis demonstrates a unique alternative splicing pattern in TNBC compared those of other cancers. In analyzing the underlying mechanism distinct profile, TDP43 , critical gene previously implicated neurodegenerative disease, found promote progression. Mechanistically, regulates extensive...
Abstract Purpose: Cervical tumor response on posttherapy 2[18F]fluoro-2-deoxy-d-glucose-positron emission tomography (FDG-PET) is predictive of survival outcome. The purpose this study was to use gene expression profiling identify pathways associated with metabolic response. Experimental Design: This a prospective tissue collection for 62 pretreatment biopsies from patients advanced cervical cancer. Patients were treated definitive radiation. Fifty-three received concurrent chemotherapy. All...
This study was devoted to compare ternary and binary deep eutectic solvents (DESs) with aqueous two-phase systems (ATPSs) extract proteins.
Breast cancer stem cells (BCSCs) are responsible for resistance to chemotherapy, high degree of metastasis, and poor prognosis, especially in triple-negative breast (TNBC). The CD24lowCD44high aldehyde dehydrogenase 1 (ALDH1) cell subpopulation (CD24lowCD44high ALDH1+) exhibit very tumor initiating capacity. In the current study, upregulated genes analyzed both ALDH1+ populations at single-cell resolution, a highly expressed membrane protein, SGCE, is identified BCSC populations. Further...
Abstract Alternative splicing (AS) is a promising clinical target for cancer treatment at the post-transcriptional level. We previously identified unique AS profile in triple-negative breast (TNBC), which regulated by regulator TAR DNA-binding protein-43 (TDP43), thus indicating crucial role of TDP43 heterogeneous TNBC. Cluster differentiation 44 (CD44), widely recognized marker stem cells (BCSCs), extensively spliced into CD44 variant isoforms (CD44v) during development cancer. At present,...
Abstract Background Intestinal fibrosis is a common complication of inflammatory bowel disease, and its core pathogenesis fibroblast activation massive extracellular matrix (ECM) deposition. In recent years, innate lymphoid cells (ILCs) have been shown to be an important source signals in fibrotic diseases. This study aims explore the heterogeneity ILC3 (the main ILC subgroup human intestine) intestinal mechanism interaction with stromal cells. Methods The model was constructed deficiency...
Background The uneven distribution of medical resources in China has led to persistently low utilization rates primary healthcare institutions. tiered delivery system aims optimize resource allocation and strengthen care, yet patient preferences for tertiary hospitals hinder its effective implementation. Understanding the factors influencing healthcare-seeking behaviors is crucial improving policies promoting efficiency. Objective To analyse choices between a hospital community health...
Abstract Milk lipid secretion is a critical process for the delivery of nutrition and energy from parent to offspring. However, underlying molecular mechanism less clear. Here we report that TDP-43, RNA-binding protein, underwent positive selection in mammalian lineage. Furthermore, TDP-43 gene ( Tardbp ) loss induces accumulation large droplets severe deficiency mammary epithelial cells outside alveolar lumens, eventually resulting lactation failure pup starvation within three weeks...
Caffeine consumption is worldwide. It has been part of our diet for many centuries; indwelled in foods, drinks, and medicines. often perceived as a “legal drug”, though it known to have detrimental effects on health, more specifically, disrupt the normal fetal development following excessive maternal intake, much ambiguity still surrounds precise mechanisms consequences caffeine-induced toxicity. Here, we employed early chick embryos developmental model assess caffeine nervous system. We...
<b><i>Background/Aims:</i></b> Acute fatty liver of pregnancy (AFLP) is a severe failure condition that has limited therapeutic approaches. We aimed to evaluate the efficacy combining plasma exchange (PE) and perfusion (PP) with conventional therapy for treatment AFLP using retrospective analysis. <b><i>Methods:</i></b> Among 22 patients AFLP, 16 cases were treated (CT group), while other 6 PE PP in addition (CT+PE+PP group). Treatment was...
Mesenchymal stromal cells (MSCs) are strongly immunosuppressive via producing nitric oxide (NO) and known to migrate into tumor sites promote growth, but the underlying mechanisms remain largely elusive. Here, we found that interferon alpha (IFNα)-secreting MSCs showed more dramatic inhibition effect on progression than of IFNα alone. Interestingly, IFNα-primed could also effectively suppress growth. Mechanistically, demonstrated both IFNβ (type I IFNs) reversed splenocyte proliferation....
Abstract Background Pediatric lupus nephritis (pLN) is one of the most refractory secondary kidney diseases in childhood. The treat-to-target (T2T) strategy has become standard treatment for systemic erythematosus (SLE). This study reviewed clinical features, overall remission status, and factors affecting prognosis, to guide pLN management according T2T strategy. Methods single-center retrospective studied 220 children diagnosed with LN from January 2012 December 2018, > 6-month...
Abstract Cancer stem cells (CSC) are supported by the tumor microenvironment, and non-CSCs can regain CSC phenotypes in certain niches, leading to limited clinical benefits of CSC-targeted therapy. A better understanding mechanisms governing orchestration niche could help improve therapeutic targeting CSCs. Here, we report that Rab13, a small GTPase, is highly expressed breast CSCs (BCSC). Rab13 depletion suppressed cancer cell stemness, tumorigenesis, chemoresistance reducing tumor-stroma...
Abstract Protein translation regulation has essential roles in inflammatory responses, cancer initiation and the pathogenesis of several neurodegenerative disorders. However, role protein mammalian skeleton development been rarely elaborated. Here we report that lack RNA-binding sterile alpha motif domain containing 4 (SAMD4) resulted multiple developmental defects mice, including delayed bone decreased osteogenesis. Samd4-deficient mesenchymal progenitors exhibit impaired osteoblast...
Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disease that targets the motor system; it caused by loss of neurons in spinal cord, brain stem, and cerebral cortex. However, etiology ALS remains unknown, although genetic factors may play an important role its development. The purpose this study was to investigate association between common polymorphisms protein disulfide isomerase (PDI) with sporadic amyotrophic (SALS) Chinese Han population. Two single...