A5101800863- Neural Networks Stability and Synchronization
- Nonlinear Dynamics and Pattern Formation
- RNA Research and Splicing
- stochastic dynamics and bifurcation
- RNA modifications and cancer
- Chaos control and synchronization
- Gout, Hyperuricemia, Uric Acid
- Mathematical Biology Tumor Growth
- Plant and fungal interactions
- Topological and Geometric Data Analysis
- Antioxidant Activity and Oxidative Stress
- Diet, Metabolism, and Disease
- RNA and protein synthesis mechanisms
- Bat Biology and Ecology Studies
- Alkaloids: synthesis and pharmacology
- Birth, Development, and Health
- Poxvirus research and outbreaks
- Hearing, Cochlea, Tinnitus, Genetics
- Free Radicals and Antioxidants
- Ruminant Nutrition and Digestive Physiology
- Plant biochemistry and biosynthesis
- Berberine and alkaloids research
- Chromatography in Natural Products
- Underwater Vehicles and Communication Systems
- Gene Regulatory Network Analysis
Kunming Institute of Zoology
2016-2024
Chinese Academy of Sciences
2011-2024
Shanghai University
2010-2012
Significance Triple-negative breast cancer (TNBC) is responsible for significant mortality among subtypes, with its treatment largely unsuccessful due to ineffective targeted therapies. Our bioinformatics analysis demonstrates a unique alternative splicing pattern in TNBC compared those of other cancers. In analyzing the underlying mechanism distinct profile, TDP43 , critical gene previously implicated neurodegenerative disease, found promote progression. Mechanistically, regulates extensive...
Abstract Mammals exhibit different rates of cancer, with long-lived species generally showing greater resistance. Although bats have been suggested to be resistant cancer due their longevity, this has yet systematically examined. Here, we investigate resistance across seven bat by activating oncogenic genes in primary cells. Both vitro and vivo experiments suggest that Myotis pilosus (MPI) is particularly cancer. The transcriptomic functional analyses reveal the downregulation three ( HIF1A...
This paper studies the synchronization of coupled chaotic systems with time-varying delays in presence parameter mismatches by means periodically intermittent control. Some novel and useful quasisynchronization criteria are obtained using methods which different from techniques employed existing works, derived results less conservative. Especially, a strong constraint on control width that should be larger than time delay imposed current references is released this paper. Moreover, our show...
Maintenance of lipid homeostasis is crucial for cells in response to requirements or surplus. The SREBP transcription factors play essential roles regulating metabolism and are associated with many metabolic diseases. However, regulation still not completely understood. Here, we showed that reduction SBP-1, the only homolog SREBPs Caenorhabditis elegans, surprisingly led a high level zinc. On contrary, zinc by mutation sur-7, encoding member cation diffusion facilitator (CDF) family,...
MiRNAs, which are a family of small non-coding RNAs, regulate broad array physiological and developmental processes. However, their regulatory roles have remained largely mysterious. E2F is positive regulator cell cycle progression also potent inducer apoptosis. Positive feedback loops in the regulation Rb-E2F pathway predicted shown experimentally. Recently, it has been discovered that induce cluster miRNAs called miR449. In turn, inhibited by miR449 through regulating different...
Tupaia belangeri (tree shrew), an animal species whose genome has significantly higher similarity to primates than rodents, been used in biomedical research. To generate models that reproduce the human tumors more faithfully we present first report of a cancer model mimicking tumor genetics tree shrew. By engineering lentiviral system for transduction mutant H-Ras and shRNA against shrew p53, successfully generated malignant glioma The exhibited aggressive behavior relatively short latency,...
The Chinese white wax scale insect, Ericerus pela, is best known for producing wax, which has been widely used in candle production, casting, medicine, and printing products thousands of years. secretion other unusual features insects, thought to be an adaptation their change from ancestral ground-dwelling lifestyle a sedentary on the higher parts plants. As well as helping improve its economic value, studies E. pela might also help explain insects. However, no genomic data are currently...
Cytotoxic indole alkaloids from Melodinus suaveolens, which belongs to the toxic plant family Apocynaceae, demonstrated impressive antitumor activities in many tumor types, but less application glioblastoma, is lethal brain tumor. In present study, we reported anti-glioblastoma activity of an alkaloid, 3α-acetonyltabersonine, was isolated suaveolens. 3α-acetonyltabersonine cytotoxic glioblastoma cell lines (U87 and T98G) stem cells at low concentrations. We verified could suppress...
Sensorineural hearing loss (SNHL) is referred to as the most common type of and typically occurs when inner ear or auditory nerve damaged. Aging, noise exposure, ototoxic drugs represent three main causes SNHL, leading substantial similarities in pathophysiological characteristics cochlear degeneration. Although molecular mechanisms are widely assumed underlie these similarities, its validity lacks systematic examination. To address this question, we generated SNHL mouse models from aging,...
Cancer stem cells (CSCs) are characterized by their ability to self-renew, differentiate into multiple cell types and also drive tumor formation, altogether making them important cellular targets for therapeutic intervention. However, existing CSC-targeting drugs do not significantly improve clinical outcomes. More recently, preclinical studies of natural product-derived compounds have demonstrated potential usefulness as a cancer treatment through cytotoxic actions on CSCs.Here, we identify...
Background Plateau zokor inhabits in sealed burrows from 2,000 to 4,200 meters at Qinghai‐Tibet Plateau. This extreme living environment makes it a great model study animal adaptation hypoxia, low temperature, and high carbon dioxide concentration. Methods We provide an integrated resource, ZokorDB, for tissue specific regulatory network annotation zokor. ZokorDB is based on high‐quality draft genome of plateau 3,300 m its transcriptional profiles brain, heart, liver, kidney, lung. The...
Due to misbalanced energy surplus and expenditure, obesity has become a common chronic disorder that is highly associated with many metabolic diseases. Pu-erh tea, traditional Chinese beverage, been believed have numerous health benefits, such as anti-obesity. However, the underlying mechanisms of its anti-obesity effect are yet be understood. Here, we take advantages transcriptional profile by RNA sequencing (RNA-Seq) view global gene expression tea. The model organism
Abstract The prenatal-to-postnatal transition is a pivotal process in the life cycle whereby an organism shifts from responding to intrauterine cues undergoing extrauterine stresses with many physiological adaptations. However, molecular basis underlying evolutionarily conserved adaptations remains elusive. Here, we analyze transcriptomes of seven organs across developmental time points five mammalian species by constructing computational coexpression networks and report shift gene...
We propose a new modularity criterion in complex networks, called the unifying q which is independent of number partitions. It shown that, for given network, relationship between upper limit Q and partitions, k, sup(Qk) = (k − 1)/k. Since range each partition inconsistent, we try to extend concept q, Subsequently, indicate that it more accurately determine partitions by using than Q.