A5056574871- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Nanowire Synthesis and Applications
- Radiomics and Machine Learning in Medical Imaging
- Virus-based gene therapy research
- Genetic factors in colorectal cancer
- Phytochemical Studies and Bioactivities
- Lung Cancer Diagnosis and Treatment
- Chromatography in Natural Products
- Lung Cancer Treatments and Mutations
- Glioma Diagnosis and Treatment
- Berberine and alkaloids research
- Advanced Breast Cancer Therapies
- Breast Cancer Treatment Studies
- Genomics and Rare Diseases
- T-cell and B-cell Immunology
- Occupational and environmental lung diseases
- Plant Gene Expression Analysis
- Head and Neck Cancer Studies
- Ferroptosis and cancer prognosis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Sichuan University
2017-2025
Wuhan Botanical Garden
2022-2024
Chinese Academy of Sciences
2017-2024
Affiliated Zhongshan Hospital of Dalian University
2022-2023
State Key Laboratory of Biotherapy
2019-2023
West China Hospital of Sichuan University
2020-2023
Guardant (United States)
2022-2023
Southern University of Science and Technology
2022
The University of Texas MD Anderson Cancer Center
2014-2022
Jinan University
2022
Cellular senescence, characterized by stable cell cycle arrest, plays an important role in aging and age-associated pathologies. Eliminating senescent cells rejuvenates aged tissues ameliorates diseases. Here, we identified that natural killer group 2 member D ligands (NKG2DLs) are up-regulated vitro, regardless of stimuli induced cellular various mice nonhuman primates vivo. Accordingly, developed demonstrated chimeric antigen receptor (CAR) T targeting human NKG2DLs selectively effectively...
Despite the great success of chimeric antigen receptor T (CAR-T)-cell therapy in treatment hematologic malignancies, CAR-T-cell is limited solid tumors, including hepatocellular carcinoma (HCC). NK group 2 member D (NKG2D) ligands (NKG2DL) are generally absent on surface normal cells but overexpressed malignant cells, offering good targets for CAR-T therapy. Indeed, analysis The Cancer Genome Atlas and HCC tumor samples showed that expression most NKG2DLs was elevated tumors compared with...
Abstract B cells are prominent components of human solid tumours, but activation status and functions these in cancers remain elusive. Here we establish that over 50% hepatocellular carcinoma (HCC) exhibit an FcγRII low/− activated phenotype, high infiltration positively correlates with cancer progression. Environmental semimature dendritic cells, not macrophages, can operate a CD95L-dependent pathway to generate cells. Early monocytes environments is critical for the generation subsequent...
<h3>Background</h3> Traditional therapies fail to cure most glioblastoma patients and the 5-year survival rate is less than 10%, highlighting need for new therapeutic approaches. The natural killer group 2 member D ligands (NKG2DLs) are highly expressed in glioblastomas considered promising targets chimeric antigen receptor (CAR) T-cell therapy. aim of this study was investigate effect NKG2D-expressing CAR-T cells on stem cells. <h3>Methods</h3> expression NKG2DLs analyzed by flow cytometry...
The mechanism by which inflammasome activation is modulated remains unclear. In this study, we identified an AIM2-interacting protein, the E3 ubiquitin ligase HUWE1, was also found to interact with NLRP3 and NLRC4 through HIN domain of AIM2 NACHT domains NLRC4. BH3 HUWE1 important for its interaction NLRP3, AIM2, Caspase-1 maturation, IL-1β release, pyroptosis were reduced in Huwe1-deficient bone marrow-derived macrophages (BMDMs) compared WT BMDMs response stimuli induce NLRC4, activation....
Existing studies reported that some circular RNAs (circRNAs) play vital roles in the development of pulmonary fibrosis. However, few explored biomarker potential circRNAs for fibrosis based on population data. Therefore, we aimed to identify peripheral blood as biomarkers diagnosing silicosis and idiopathic (IPF). In brief, an RNA-seq screening 4 cases controls was initially performed. Differentially expressed were combined with human serum circRNA dataset overlapping serum-detectable...
Abstract Background Glioblastoma (GBM) is recognized as among the most aggressive forms of brain tumor. Patients typically present with a five-year survival rate less than 6% traditional surgery and chemoradiotherapy, which calls for novel immunotherapies like chimeric antigen receptor T (CAR-T) cells therapy. In response to endoplasmic reticulum (ER) stress in multiple tumor including GBM, glucose-regulated protein 78 (GRP78) expression increases partially translocated cell surface, while...
The receptor tyrosine kinases TAM family (TYRO3, AXL, and MERTK) are highly expressed in multiple forms of cancer cells tumor-associated macrophages promote the development cancers including pancreatic tumor. Targeting receptors could be a promising therapeutic option.We designed novel CAR based on extracellular domain growth arrest-specific protein 6 (GAS6), natural ligand for all members. ability CAR-T to kill is tested vitro vivo, safety evaluated mice nonhuman primate.GAS6-CAR-T...
Lung cancer is the most frequent type and leading cause of tumor-associated deaths worldwide.TP53 an important tumor suppressor gene frequently inactivated in lung cancer.E3 ligases targeting p53, such as MDM2, are involved development cancer.The E3 ligase HUWE1, which targets many proteins including has been reported to be highly expressed cancer; however, its role tumorigenesis unclear.Methods: The expression HUWE1 p53 cells was modulated phenotypes were assessed by performing soft agar...
Abstract Triple-negative breast cancer (TNBC) is an aggressive malignancy in which the tumors lack expression of estrogen receptor, progesterone and HER2. Hence, TNBC patients cannot benefit from clinically available targeted therapies rely on chemotherapy surgery for treatment. While initially responding to chemotherapy, are at increased risk developing distant metastasis have decreased overall survival compared with non-TNBC patients. A majority carry p53 mutations, enabling them bypass G1...
Research into the biology of soft tissue sarcomas has uncovered very few effective treatment strategies that improve upon current standard care which usually involves surgery, radiation, and chemotherapy. Many patients with large (>5 cm), high-grade develop recurrence, at point have limited options available. One challenge is heterogeneity genetic drivers sarcomas, many these are not validated targets. Even when such genes tractable targets, rarity each subtype sarcoma makes advances in...
Abstract Chimeric antigen receptor (CAR) T cells have demonstrated promising results in hematological malignancies; however, challenges remain treating solid tumors. New CARs with more effectiveness and lower side effects are needed. Ephrin type‐A 2 (EphA2) belongs to the family of tyrosine kinases, which is overexpressed several malignancies. Compared some single‐chain variable fragment (ScFv) that exhibit excessively high affinity for their targets, natural receptor/ligand‐based maintain...
Ubiquitination-directed protein degradation is important in many cancers for tumor initiation and maintenance, E3 ligases containing HECT domains are emerging as new therapeutic targets. In contrast to other ligases, the role of HUWE1 ovarian cancer where dysregulated has been unclear. Here we report that genetic deletion Huwe1 mouse inhibits transformation ovary surface epithelium cells without significantly affecting cell survival apoptosis, after tumors have initiated growth....
Many targeted therapies are currently available only via clinical trials. Therefore, routine precision oncology using biomarker-based assignment to drug depends on matching patients A comprehensive and up-to-date trial database is necessary for optimal patient-trial matching.
Objective To evaluate the association between single-nucleotide polymorphisms (SNPs) in RNA-seq identified mRNAs and silicosis susceptibility. Methods A comprehensive was performed to screen for differently expressed peripheral blood lymphocytes of eight subjects exposed silica dust (four cases four healthy controls). Following this, SNPs located on shortlisted mRNAs, which may affect susceptibility, were screened through silicosis-related genome-wide studies (GWAS) (155 141 controls),...
The identification of biomarker-driven targeted therapies for patients with triple negative breast cancer (TNBC) remains a major clinical challenge, due to lack specific targets. Here, we show that cyclin E, regulator G1 S transition, is deregulated in TNBC and associated mutations DNA repair genes (e.g., BRCA1/2). Breast cancers high levels E not only have higher prevalence BRCA1/2 mutations, but also are the worst outcomes. Using several vitro vivo model systems, TNBCs harbor either or...
Chimeric antigen receptor (CAR) T-cell therapy is emerging as an effective cancer treatment, such for hematological malignancies, however its effectiveness approach to treat solid tumors, in colorectal (CRC), remains be better developed. One area of intense development has been the identification and characterization novel cancer-related ligand receptors CAR design evaluation. It known that CD6 CD166 CD318 are highly expressed CRC, several CAR-Ts have also explored preclinical clinical...