A5001267578- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- Lung Cancer Research Studies
- Cancer therapeutics and mechanisms
- Thyroid Cancer Diagnosis and Treatment
- Cancer and Skin Lesions
- Salivary Gland Tumors Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Soft tissue tumor case studies
- Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Breast Implant and Reconstruction
- AI in cancer detection
- MRI in cancer diagnosis
- Ovarian cancer diagnosis and treatment
- Head and Neck Anomalies
- Nonmelanoma Skin Cancer Studies
- Thyroid and Parathyroid Surgery
- BRCA gene mutations in cancer
- Sarcoma Diagnosis and Treatment
- Ear and Head Tumors
- Cancer-related Molecular Pathways
Dokuz Eylül University
2015-2025
Dokuz Eylül Üniversitesi Hastanesi
2022-2024
The University of Texas MD Anderson Cancer Center
2019-2023
Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors are currently used in combination with endocrine therapy to treat advanced hormone receptor-positive, HER2-negative breast cancer. Although this treatment doubles time progression compared alone, about 25%-35% of patients do not respond, and almost all eventually acquire resistance. Discerning the mechanisms resistance CDK4/6 inhibition is crucial devising alternative strategies.Palbociclib-resistant cells (MCF-7 T47D) were generated a...
This study was performed to compare the mammographic, sonographic, and magnetic resonance imaging (MRI) characteristics of phyllodes tumors fibroadenomas, which may resemble each other.Preoperative mammograms, B-mode Doppler sonograms, dynamic breast MRIs 72 patients with pathologically proven fibroadenomas 70 tumor were evaluated in this retrospective study. Statistical significance using chi-square Fisher's exact tests. Correlations lesion size among radiological methods examined by...
Invasive micropapillary carcinoma (IMPC) of the breast is an uncommon, highly aggressive cancer that may occur in pure and mixed forms. Our aim this study to investigate relationship between clinical, histopathologic, immunohistochemical features IMPC cases diagnosed treated at our institution. One hundred three institution over a period 19 years have been selected. Clinical, histopathologic features, as well hormone status c-erb-B2 overexpression tumors were re-evaluated. Mann-Whitney U,...
Abstract Neoadjuvant chemotherapy (NAC) is well-established for locally advanced breast cancer, even in the early stages, especially HER2-positive and triple-negative cases. However, effect of chronologic age on NAC response remains controversial. This study investigates efficacy outcomes older patients with compared to a younger cohort, address current knowledge gap. 535 who received followed by curative surgery from 2010 2021 were retrospectively analyzed. We evaluated axillary...
The identification of biomarker-driven targeted therapies for patients with triple negative breast cancer (TNBC) remains a major clinical challenge, due to lack specific targets. Here, we show that cyclin E, regulator G1 S transition, is deregulated in TNBC and associated mutations DNA repair genes (e.g., BRCA1/2). Breast cancers high levels E not only have higher prevalence BRCA1/2 mutations, but also are the worst outcomes. Using several vitro vivo model systems, TNBCs harbor either or...
Background/aim: Phyllodes tumors (PTs) of the breast are rare, and their diagnosis treatment remain controversial. This retrospective study aims to examine clinical outcome benign borderline PTs, according surgical margins. Materials methods: We examined medical records 122 patients in our clinic, who had histologically confirmed PTs between 1994 2017. Results: The mean age was 40.6 years (range 18.0-81.0, ±12.1 standard deviation [SD]) tumor size 25.8 mm 9-65, ±10.3 SD). All underwent a...
Metaplastic breast cancer (MBC) is a rare subtype of invasive characterized by mixed epithelial and mesenchymal differentiation. Commonly seen subtypes include squamous cell carcinoma, spindle metaplastic carcinoma with heterologous MBC tends to have more aggressive clinical presentation, higher metastatic potential, rates local recurrence, worse prognosis compared no special type. Most MBCs are triple-negative cancers, which explains their resistance most systemic therapies. Therefore,...
Objective: Pathology education includes an important visual part supporting a wide range of theoretical knowledge.However, the use traditional microscopes in pathology has declined over last decade and there is lack interest for microscopy.Virtual microscopy, which was first described 1985 experienced revolution since 2000, alternative technique to conventional microscopic slides are scanned form digital images stored web.The aim this study evaluate virtual microscopy practical sessions its...
Background/aim: To determine the prevalence of malignancy in thyroid incidentalomas (TIs) detected by fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT). Materials and methods: 18F-FDG PET/CT images were evaluated prospectively for presence uptake. The patients with a TI an endocrinologist according to predefined diagnostic algorithm. final diagnosis was obtained clinically and/or pathology. Results: 4.2% 4204 patients. A malignant nodule...
In routine practice, axillary lymph node dissection is performed in early invasive breast cancer patients with positive sentinel biopsy. However, the only involved 40-70% of patients, and determining factors that predict non-sentinel involvement will therefore prevent unnecessary decrease morbidity.In this study, 119 metastasis who underwent between 1998-2009 at our institution were studied. Primary tumor characteristics features metastatic tumors nodes, such as microanatomic location, size...
As patients with increased human epidermal growth factor receptor (HER2) overexpression are more likely to benefit from trastuzumab treatment, the accuracy of HER2 status in breast cancer is significant for appropriate disease management. However, this assessment not harmonized and results may be highly variable between centers. The aim study was investigate degree interlaboratory variability expression reported by 5 participating centers assess concordance these a reference...
Objective: The reliability of traditional methods such as physical examination, ultrasonography (US) and mammography is limited in determining the type treatment response patients with neoadjuvant chemotherapy (NAC) application for locally advanced breast cancer (LABC).Dynamic contrast-enhanced magnetic resonance imaging (MRI) gaining popularity evaluation NAC response.This study aimed to compare determined by dynamic MRI LABC histopathology that gold standard; evaluate compatibility MRI, US...
Solitary fibrous tumors are unusual neoplasms that rarely found in the liver parenchyma.Th ey usually described as hard, grayish white, well-defined lesions.Predominant cystic change a solitary tumor is an unexpected finding, with only few previous cases reported literature, two of which localized head and neck region.Herein, we report unique case 38-year-old female predominant multiloculated appearance, discuss histopathologic diff erential diagnosis.
Fibroadenoma is the most common breast tumor in adolescent and young women.Fibroadenomas that consist of sclerosing adenosis, papillary apocrine metaplasia, epithelial calcifications, and/or cysts greater than 3 mm are considered as complex fibroadenoma.The relative risk developing cancer patients with fibroadenoma increased, compared to women noncomplex fibroadenoma.Extensive cystic degeneration a fibroadenoma, so called "cystic fibroadenoma" very rare.Herein, we present case such lesion...
Background/aim: This study aimed to report invasive cribriform carcinoma (ICC) with radiological and histopathologic correlations. Materials methods: Seventy patients ICC were classified into two groups; pure >50% component included in group 1, while <50% 2. All reviewed according American College of Radiology (ACR) breast imaging reporting data system (BI-RADS) lexicon mammography (MG), ultrasonography (US), magnetic resonance (MRI). One-way analysis variance tests t-tests used for...
Background/aim: This study aimed to compare the apparent diffusion coefficient (ADC) values of malignant breast lesions with different histopathological types on diffusion-weighted imaging (DWI) and cellular region/stroma (CR/S) ratio results. Materials methods: Breast magnetic resonance findings 59 patients were retrospectively analyzed for lesions. The CR/S was calculated using wide-excisional biopsy or mastectomy specimens. Results: Receiver operating characteristic analysis performed...