A5102969782- Breast Cancer Treatment Studies
- Renal cell carcinoma treatment
- HER2/EGFR in Cancer Research
- Multiple and Secondary Primary Cancers
- Genetic factors in colorectal cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Breast Lesions and Carcinomas
- Gastric Cancer Management and Outcomes
- Economic and Financial Impacts of Cancer
- Prostate Cancer Treatment and Research
- Palliative Care and End-of-Life Issues
- Inflammatory Biomarkers in Disease Prognosis
- Cancer survivorship and care
- Cancer Treatment and Pharmacology
- Colorectal and Anal Carcinomas
- Chemotherapy-induced cardiotoxicity and mitigation
- Ovarian cancer diagnosis and treatment
- Gastrointestinal disorders and treatments
- Advanced Breast Cancer Therapies
- Metal complexes synthesis and properties
- Ferrocene Chemistry and Applications
- Cancer Mechanisms and Therapy
- Breast Implant and Reconstruction
- Childhood Cancer Survivors' Quality of Life
- Bladder and Urothelial Cancer Treatments
Dokuz Eylül University
2022-2025
Ministry of Health
2024
Izmir Tepecik Eğitim ve Araştırma Hastanesi
2024
Dokuz Eylül Üniversitesi Hastanesi
2022-2024
Manisa Celal Bayar University
2022
Hacettepe University
2021
Memorial Ankara Hospital
2019
BackgroundCDK4/6 inhibitors combined with endocrine therapy have significantly improved treatment outcomes for metastatic hormone receptor-positive (HR+) breast cancer patients. However, the impact of low HER2 expression on response and progression-free survival (PFS) remains unclear.MethodsThis multicenter retrospective study included 204 HR+ patients treated a combination CDK4/6 inhibitor therapy. HER2-zero disease was detected in 138 (68%) HER2-low 66 (32%) Treatment-related...
Abstract Neoadjuvant chemotherapy (NAC) is well-established for locally advanced breast cancer, even in the early stages, especially HER2-positive and triple-negative cases. However, effect of chronologic age on NAC response remains controversial. This study investigates efficacy outcomes older patients with compared to a younger cohort, address current knowledge gap. 535 who received followed by curative surgery from 2010 2021 were retrospectively analyzed. We evaluated axillary...
Background/Objectives: The precise role of volumetric body composition (VBC) parameters, visceral adipose tissue index (VATI), subcutaneous (SATI), and skeletal muscle (SMI) on the survival metastatic renal cell carcinoma (mRCC) is not fully elucidated. Herein, present study investigated clinical significance baseline VBC parameters their changes after 3–4 months from treatment initiation in patients with mRCC treated first-line targeted therapy. Methods: A total 108 were enrolled. depicted...
Abstract Biomarkers such as hormone receptors (HR) and human epidermal growth factor receptor2 (HER2) may change after neoadjuvant chemotherapy (NAC) in breast cancer patients. The aim of this study was to investigate the rates receptor NAC evaluate prognostic impact change. Patients with who received were included study. Changes pathological findings (ER, PR, HER-2, Ki-67, grade) before examined. In addition, effect exchange on prognosis evaluated. Kaplan Meier analysis used for survival...
Background: In this study, we aimed to investigate the frequency, prognostic effect of codon, and amino acid-specific KRAS mutations in patients with metastatic colorectal cancer (mCRC) their predictive on irinotecan oxaliplatin during first-line treatment.Methods: The data 304 mCRC were retrospectively evaluated between 2010 2018. Patients categorized according most prominent codon acid mutation features analyzed.Results: total, 274 included study 128 (47%) revealed mutation. Median...
Abstract Purpose Biomarkers such as hormone receptors (HR) and human epidermal growth factor receptor2 (HER2) found in breast cancer cells may undergo changes after neoadjuvant chemotherapy (NACT).This study aimed to investigate receptor change rates NACT determine the prognostic impact of change. Material Method : Patients with who received were included study. Changes pathological findings before examined. In addition, effect exchange on prognosis was evaluated. Results The 203 female...
Hepatocellular carcinoma (HCC) remains a major challenge in oncology, being leading cause of cancer-related mortality worldwide. Early-stage HCC is typically treated with surgical resection, transplantation, or ablation, while advanced-stage relies on systemic therapies like sorafenib and newer combinations such as atezolizumab-bevacizumab. Despite these advancements, there still need for effective treatments unresectable HCC, especially cases macroscopic vascular invasion. Hepatic arterial...
N3 gastric cancer is characterized by a fairly high lymph node metastasis burden and poor outcome despite optimal therapy. Given the limitations of TNM classification, comprehensive evaluation tool necessary to predict prognosis patients with who underwent curative surgery. This study aims explore outcomes clinicopathologic prognostic factors affecting overall survival (OS) after surgery.Data on (sub)total gastrectomy regional dissection between November 2005 September 2018 (n = 169) were...
At the time of diagnosis, approximately 16.5% prostate cancer patients are metastatic. The main framework metastatic treatment is androgen deprivation therapy, which performed surgically or medically. aim this study to evaluate attitudes medical oncologists and urologists about orchiectomy as therapy.A total 387 physicians working in Departments Urology (n=217) Medical Oncology (n=170) were included descriptive study. Data collected through an electronic survey.Only 7.5% participants...
Amaç: Yeni nesil pek çok tedaviye rağmen oldukça kötü prognoza sahip metastatik renal hücreli
 karsinom (mRHK) tanılı hastalarda günümüze kadar kullanılan prognostik belirteçlerin her hastada
 prognozu doğru tayin edemediği bilinmektedir. Bu nedenle biyobelirteç arayışı sürmektedir.
 çalışmada mRHK hastalarında tedavi öncesi biyokimyasal parametrelerin onkolojik sonuçlara
 etkisini araştırmak amaçlandı.
 Gereç ve Yöntemler: Kliniğimizde 2007-2020 tarihleri arasında...
Endometrial cancer (EC) is among the most common gynecological cancers in developed countries. 1,2Owing to a slower course compared other cancers, curing possibility high with early diagnosis and treatment.Adjuvant chemotherapy or radiotherapy not needed many cases surgery. 3Two histological categories differ EC terms of incidence, response hormones, clinical behavior. 4Type I tumors are generally Grade 1 2 tumors, 80% belonging this category.These have good prognosis.Type II constitute...
To evaluate the effect of pretreatment C-reactive protein (CRP)/Albumin ratio (CAR) on prognosis and its association with IMDC (International metastatic renal cell carcinoma database consortium) risk score overall survival (OS) in (mRCC) patients.Descriptive study.Department Medical Oncology, Dokuz Eylul University, Izmir, Turkey, between 2007 2020.Clinico-pathological treatment-related data mRCC patients were retrospectively evaluated included study. CAR was used as a prognostic...
Abstract No biomarker is currently available for early detection of anthracycline-induced cardiotoxicity. The purpose this study was to assess whether the plasma levels microRNA34a (miR34a) could predict cardiotoxicity in breast cancer patients who received anthracycline-based chemotherapy.Forty-four chemotherapy first time were included study. Before and after taking chemotherapy, examined cardiac troponin-I, miR34a, precursor miR34a levels, echocardiographic strain analyses performed....