Is CRP/Albumin Ratio (CAR) a New Parameter to be Added to Risk Stratification Systems in Metastatic Renal Cell Carcinoma Patients?

• DOI: 10.29271/jcpsp.2022.11.1425
• Publication Date: 2022-11-21T03:43:25Z
• Authors: Mehmet Uzun; Eda Caliskan Yild...; Ferhat Ekinci; Hüseyin Salih Semiz
• Keywords: Risk Stratification

To evaluate the effect of pretreatment C-reactive protein (CRP)/Albumin ratio (CAR) on prognosis and its association with IMDC (International metastatic renal cell carcinoma database consortium) risk score overall survival (OS) in (mRCC) patients.Descriptive study.Department Medical Oncology, Dokuz Eylul University, Izmir, Turkey, between 2007 2020.Clinico-pathological treatment-related data mRCC patients were retrospectively evaluated included study. CAR was used as a prognostic inflammatory score. threshold value for OS has been obtained by ROC analysis. The tested using Kaplan-Meier Cox-regression models. IMDC-CAR model created adding to stratification.OS 91 months below 0.072 (<0.072), while 51 above (p=0.005). According stratification, intermediate poor groups showed similar times (p>0.05). However, when added group, it divided into 3 subgroups different prognoses (p=0.02).CAR is an independent predictor patients. In this study, demonstrated that more accurate prediction could be made indicators which constitutes highly heterogeneous group according stratification.Renal cancer, Albumin, protein, IMDC, Prognosis.