A5102965329- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Cancer survivorship and care
- Cancer-related Molecular Pathways
- Cancer Treatment and Pharmacology
- Estrogen and related hormone effects
- Cancer-related cognitive impairment studies
- Endometrial and Cervical Cancer Treatments
- Genetics, Bioinformatics, and Biomedical Research
- Palliative Care and End-of-Life Issues
- Family Support in Illness
- Breast Lesions and Carcinomas
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Treatments and Studies
- Psoriasis: Treatment and Pathogenesis
- Menopause: Health Impacts and Treatments
- Nutrition, Genetics, and Disease
- Management of metastatic bone disease
- Growth Hormone and Insulin-like Growth Factors
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Digestive system and related health
- Glioma Diagnosis and Treatment
Izmir University
2021-2024
Sağlık Bilimleri Üniversitesi
2023-2024
Izmir Tepecik Eğitim ve Araştırma Hastanesi
2023-2024
Dokuz Eylül University
2017-2021
Ribociclib, palbociclib and abemaciclib are currently approved CDK4/6 inhibitors along with aromatase as the first-line standard-of-care for patients hormone receptor-positive, HER2-negative metastatic breast cancer.
BackgroundCDK4/6 inhibitors combined with endocrine therapy have significantly improved treatment outcomes for metastatic hormone receptor-positive (HR+) breast cancer patients. However, the impact of low HER2 expression on response and progression-free survival (PFS) remains unclear.MethodsThis multicenter retrospective study included 204 HR+ patients treated a combination CDK4/6 inhibitor therapy. HER2-zero disease was detected in 138 (68%) HER2-low 66 (32%) Treatment-related...
Abstract Biomarkers such as hormone receptors (HR) and human epidermal growth factor receptor2 (HER2) may change after neoadjuvant chemotherapy (NAC) in breast cancer patients. The aim of this study was to investigate the rates receptor NAC evaluate prognostic impact change. Patients with who received were included study. Changes pathological findings (ER, PR, HER-2, Ki-67, grade) before examined. In addition, effect exchange on prognosis evaluated. Kaplan Meier analysis used for survival...
Background & aims Prognostic factors of metastatic rectal cancer are not well known. We aim to determine prognostic affecting survival for patients and also investigate the effect tumor localization on overall survival. Methods Metastatic who received treatment in 5 different centers between 2012 2022 were included. evaluated using univariate multivariate analysis. The statistical methods included Pearson’s chi-square test, Fisher exact Log-rank Cox regression model. Results A total...
Background Depression is one of the most prevalent causes distress in geriatric population. The purpose this study was to examine prevalence depressive symptoms elderly cancer patients and determine possible associated factors. Methods Cancer 65 years or older on active chemotherapy completed Yesavage Geriatric Scale. We examined relationship with age, gender, marital status, educational background, type cancer, stage disease, comorbidities, types treatment for duration after diagnosis...
Introduction: Information regarding HER2-low tumors in metastatic gastric cancer is sparse. Our aim here was to determine the frequency of low HER2 expression and compare clinicopathological characteristics, survival, treatment response patients with HER2-zero patients. Methods: The features, responses, survival were compared. Results: Of 226 patients, 71 (31.4%) had 155 (68.6%) zero expression. detected more frequently older low-grade than (69% vs. 47.7%, p = 0.003, 16.9% 3.8%, <...
Abstract Purpose Biomarkers such as hormone receptors (HR) and human epidermal growth factor receptor2 (HER2) found in breast cancer cells may undergo changes after neoadjuvant chemotherapy (NACT).This study aimed to investigate receptor change rates NACT determine the prognostic impact of change. Material Method : Patients with who received were included study. Changes pathological findings before examined. In addition, effect exchange on prognosis was evaluated. Results The 203 female...
Background Triple negative breast cancer (TNBC) is characterized by high rates of recurrence, especially in patients with residual disease after neoadjuvant chemotherapy (NAC). Capecitabine being used as standard adjuvant treatment TNBC. We aimed to investigate the real-life data regarding efficacy capecitabine
Highly selective inhibitors of cyclin-dependent kinase 4 and 6 (CDK4/6is) have emerged as a standart care for first- second-line therapies in combination with endocrine therapy (ET) HR+/HER2- metastatic breast cancer (MBC) patients. It has been reported that is more effective than ET alone safe elderly patients well young Nevertheless, very old HR+/HER2-MBC treated CDK4/6 inhibitor (CDK4/6i) combinations are relatively underrepresented randomized controlled trials. To contribute to the...
Objectives. The aim of this study was to investigate the validity and reliability Turkish version National Comprehensive Cancer Network/Functional Assessment Therapy Ovarian Symptom Index-18 (NFOSI-18) Functional Therapy/Gynecologic Oncology Group Neurotoxicity 4-item (NTX-4) in patients with advanced ovarian cancer (OC). Methods. Ninety-four women OC were included. Pearson correlation coefficients used examine convergent between European Quality Life Survey-5 Dimension-3 Level (EQ-5D-3L)...
<h3>Background</h3> Several studies have found a higher prevalence of type 2 diabetes mellitus in patients with psoriasis and psoriatic arthritis (PsA). Interestingly, complete remission has been observed following immediately after the gastric bypass surgery obese diabetic before any weight loss could occurred, most likely due to increased levels GLP-1. There also cases who showed improvements under treatment GLP-1 receptor agonists dipeptidyl peptidase-IV (DPP-IV) inhibitors.GLP-1 was...
Oligometastaz, lokalize hastalık ile yaygın arasında yer alan biyolojik
<b>Background:</b> Many studies have noted that the symptoms progress with dyspnea cycle, wherein develops, activity is avoided, functional loss, and worsens in chronic lung disease. Physical improves symptom burden, exercise tolerance quality of life. Therefore, use physical as a therapeutic method increasing both disease many types cancer. <b>Aims:</b> The aim this study was to investigate determinants individuals cancer who has received chemotherapy. <b>Methods:</b> Twenty-eight patients...
Purpose: The aim of this study was to explore lived experiences partners breast cancer survivors. Methods: A descriptive phenomenological approach used. Participants were purposively sampled from a University hospital in Turkey. Semi-structured individual interviews conducted with 12 Results: Three themes identified: difficulties, re-adaptation life, and new perspectives life. Conclusion: Healthcare professionals should investigate the stressors psychosocial well-being follow-ups. In...